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1.发明公开公开(公告)号：US20230250490A1
公开(公告)日：2023-08-10
申请号：US18167664
申请日：2023-02-10
IPC分类号： C12Q1/689
CPC分类号： C12Q1/689 , C12Q2600/106
摘要： Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. The methods are based on the temporal difference in the shift of the ratio of Bacteroidetes to Firmicutes in subgingival plaque samples taken from healthy tissue that is distant from the site of plaque induced inflammation. Methods of treating gingivitis and methods of preventing, reducing the severity of or delaying onset of gingivitis in an individual who is a slow gingivitis responder or a high gingivitis responder are disclosed.
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公开(公告)号：US20180256468A1
公开(公告)日：2018-09-13
申请号：US15978549
申请日：2018-05-14
发明人： Zhiqiang LIU , Long PAN , Shaotang YUAN , Jairajh MATTAI , James MASTERS
CPC分类号： A61K8/44 , A61K8/0216 , A61K8/20 , A61K8/27 , A61K2800/45 , A61K2800/58 , A61Q11/00
摘要： Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
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公开(公告)号：US20180243193A1
公开(公告)日：2018-08-30
申请号：US15964193
申请日：2018-04-27
发明人： Long Pan , Shaotang YUAN , Shira PILCH , James MASTERS , Zhiqiang LIU
摘要： Disclosed herein are mouthwashes comprising a complex of a zinc ion source and an amino acid. Methods of making and using the compositions are also provided.
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公开(公告)号：US20170367953A1
公开(公告)日：2017-12-28
申请号：US15629097
申请日：2017-06-21
发明人： Dandan Chen , Ying YANG , Robert D'AMBROGIO , Paul THOMSON , Harsh Mahendra TRIVEDI , Michael PRENCIPE , James MASTERS , Stanislav JARACZ
摘要： This invention relates to oral care compositions comprising zingerone, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
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公开(公告)号：US20230076737A1
公开(公告)日：2023-03-09
申请号：US17668456
申请日：2022-02-10
IPC分类号： G01N33/68
摘要： Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.
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公开(公告)号：US20220332742A1
公开(公告)日：2022-10-20
申请号：US17723953
申请日：2022-04-19
发明人： Viktor DUBOVOY , Jane ONG , James MASTERS , Long PAN
IPC分类号： C07F15/02 , A61K31/7048 , A61K8/19 , A61K8/60 , A61Q11/00
摘要： This invention relates to compositions, including oral care compositions, comprising naringin-loaded metal-organic frameworks (MOFs), such as naringin-loaded MIL-101(Fe), as well as methods of using and of making these compositions.
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公开(公告)号：US20220071868A1
公开(公告)日：2022-03-10
申请号：US17309895
申请日：2019-12-17
摘要： Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc oxide, zinc citrate, stannous fluoride, and optionally arginine and/or zingerone.
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公开(公告)号：US20190015310A1
公开(公告)日：2019-01-17
申请号：US16135136
申请日：2018-09-19
发明人： Long PAN , Shaotang YUAN , Shira PILCH , James MASTERS , Zhiqiang LIU
CPC分类号： A61K8/58 , A61K8/20 , A61K8/21 , A61K8/27 , A61K8/44 , A61K2800/58 , A61K2800/74 , A61Q11/00
摘要： Disclosed herein are oral care compositions comprising a zinc amino acid halide. Methods of making and using the compositions are also provided.
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公开(公告)号：US20180110712A1
公开(公告)日：2018-04-26
申请号：US15791812
申请日：2017-10-24
发明人： Jane Ong , James MASTERS , Tatiana BRINZARI , Chi-Yuan CHENG , Donghui WU , Long PAN
CPC分类号： A61K8/602 , A61K8/27 , A61K8/498 , A61K2800/51 , A61K2800/58 , A61Q11/00
摘要： Disclosed herein are oral care compositions comprising naringin:Zinc complexes having a 2:1 naringin to zinc molar ratio. Methods of making and using the compositions are also provided.
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公开(公告)号：US20170368376A1
公开(公告)日：2017-12-28
申请号：US15629190
申请日：2017-06-21
发明人： Ying Yang , Dandan CHEN , Robert D'AMBROGIO , Paul THOMSON , Harsh Mahendra TRIVEDI , Michael PRENCIPE , James MASTERS , Stanislav JARACZ
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/22 , A61K8/27 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/97 , A61K36/9068 , A61K45/06 , A61Q17/005
摘要： This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
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