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1.发明公开公开(公告)号：US20230250490A1
公开(公告)日：2023-08-10
申请号：US18167664
申请日：2023-02-10
IPC分类号： C12Q1/689
CPC分类号： C12Q1/689 , C12Q2600/106
摘要： Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. The methods are based on the temporal difference in the shift of the ratio of Bacteroidetes to Firmicutes in subgingival plaque samples taken from healthy tissue that is distant from the site of plaque induced inflammation. Methods of treating gingivitis and methods of preventing, reducing the severity of or delaying onset of gingivitis in an individual who is a slow gingivitis responder or a high gingivitis responder are disclosed.
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公开(公告)号：US20230076737A1
公开(公告)日：2023-03-09
申请号：US17668456
申请日：2022-02-10
IPC分类号： G01N33/68
摘要： Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.
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