公开(公告)号：US20230250490A1

公开(公告)日：2023-08-10

申请号：US18167664

申请日：2023-02-10

Applicant: Colgate-Palmolive Company

Inventor： Dandan CHEN ,  Harsj Mahendra TRIVEDI ,  James MASTERS ,  Richard P. DARVEAU ,  Jeffrey S. MCLEAN

IPC: C12Q1/689

CPC classification number: C12Q1/689 ,  C12Q2600/106

Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. The methods are based on the temporal difference in the shift of the ratio of Bacteroidetes to Firmicutes in subgingival plaque samples taken from healthy tissue that is distant from the site of plaque induced inflammation. Methods of treating gingivitis and methods of preventing, reducing the severity of or delaying onset of gingivitis in an individual who is a slow gingivitis responder or a high gingivitis responder are disclosed.