公开(公告)号：US12163162B2

公开(公告)日：2024-12-10

申请号：US18164522

申请日：2023-02-03

Applicant: Codexis, Inc.

Inventor： Fabien Louis Cabirol ,  Haibin Chen ,  Anupam Gohel ,  Paulina Elena Salim ,  Derek J. Smith ,  Jacob Janey ,  Birgit Kosjek ,  Weng Lin Tang ,  Helen Hsieh ,  Son Q. Pham

IPC: C12N9/10 ,  C07D211/76 ,  C12N1/21 ,  C12P13/00 ,  C12P17/12

Abstract: The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.

公开(公告)号：US20220106575A1

公开(公告)日：2022-04-07

申请号：US17553455

申请日：2021-12-16

Applicant: Codexis, Inc.

Inventor： Oscar Alvizo ,  Nicholas J. Agard ,  Xinkai Xie ,  David Entwistle ,  Birgit Kosjek

IPC: C12N9/04 ,  C12P17/12 ,  C12P41/00 ,  C12P7/40 ,  C12P7/02

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

公开(公告)号：US11236308B2

公开(公告)日：2022-02-01

申请号：US16874574

申请日：2020-05-14

Applicant: Codexis, Inc.

Inventor： Oscar Alvizo ,  Nicholas J. Agard ,  Xinkai Xie ,  David Entwistle ,  Birgit Kosjek

IPC: C12N9/04 ,  C12P41/00 ,  C12P7/02 ,  C12P17/12 ,  C12P7/40

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

公开(公告)号：US20210032605A1

公开(公告)日：2021-02-04

申请号：US17072910

申请日：2020-10-16

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02 ,  C12P17/12

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US20230272354A1

公开(公告)日：2023-08-31

申请号：US18180711

申请日：2023-03-08

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02 ,  C12P17/12

CPC classification number: C12N9/0071 ,  C12P17/12 ,  C12Y114/11002 ,  C12Y114/11

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US11713451B2

公开(公告)日：2023-08-01

申请号：US17084405

申请日：2020-10-29

Applicant: Codexis, Inc.

Inventor： Fabien Louis Cabirol ,  Haibin Chen ,  Anupam Gohel ,  Steven J. Collier ,  Derek J. Smith ,  Birgit Kosjek ,  Jacob Janey

IPC: C12N15/70 ,  C12N9/00 ,  C12N9/04 ,  C12P41/00 ,  C12P13/00 ,  C12P13/02

CPC classification number: C12N9/0006 ,  C12P13/00 ,  C12P13/001 ,  C12P13/02 ,  C12P41/002 ,  C12Y101/01184 ,  C12N15/70 ,  Y02P20/52

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

公开(公告)号：US20190078061A1

公开(公告)日：2019-03-14

申请号：US16196205

申请日：2018-11-20

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US10184117B2

公开(公告)日：2019-01-22

申请号：US15491692

申请日：2017-04-19

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US10100287B2

公开(公告)日：2018-10-16

申请号：US15711119

申请日：2017-09-21

Applicant: Codexis, Inc.

Inventor： Fabien Louis Cabirol ,  Haibin Chen ,  Anupam Gohel ,  Steven J. Collier ,  Derek J. Smith ,  Birgit Kosjek ,  Jacob Janey

IPC: C12N9/04 ,  C12N15/00 ,  C12P13/02 ,  C12P13/00 ,  C12P41/00 ,  C12N15/70

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

公开(公告)号：US09803178B2

公开(公告)日：2017-10-31

申请号：US15211990

申请日：2016-07-15

Applicant: Codexis, Inc.

Inventor： Fabien Louis Cabirol ,  Haibin Chen ,  Anupam Gohel ,  Steven J. Collier ,  Derek J. Smith ,  Birgit Kosjek ,  Jacob Janey

IPC: C07H21/04 ,  C12N15/70 ,  C12N9/02 ,  C12N9/04 ,  C12P41/00 ,  C12P13/00 ,  C12P13/02

CPC classification number: C12N9/0006 ,  C12N15/70 ,  C12P13/00 ,  C12P13/001 ,  C12P13/02 ,  C12P41/002 ,  C12Y101/01184 ,  Y02P20/52

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.