公开(公告)号：US20210032605A1

公开(公告)日：2021-02-04

申请号：US17072910

申请日：2020-10-16

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02 ,  C12P17/12

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US11634695B2

公开(公告)日：2023-04-25

申请号：US17072910

申请日：2020-10-16

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02 ,  C12P17/12

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US20170355968A1

公开(公告)日：2017-12-14

申请号：US15491692

申请日：2017-04-19

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02

CPC classification number: C12N9/0071 ,  C12Y114/11

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US20230272354A1

公开(公告)日：2023-08-31

申请号：US18180711

申请日：2023-03-08

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02 ,  C12P17/12

CPC classification number: C12N9/0071 ,  C12P17/12 ,  C12Y114/11002 ,  C12Y114/11

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US20190078061A1

公开(公告)日：2019-03-14

申请号：US16196205

申请日：2018-11-20

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US10184117B2

公开(公告)日：2019-01-22

申请号：US15491692

申请日：2017-04-19

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Robert Osborne ,  Jack Liang ,  Jonathan Vroom ,  Xiyun Zhang ,  David Entwistle ,  Rama Voladri ,  Ravi David Garcia ,  Jeffrey C. Moore ,  Shane Grosser ,  Birgit Kosjek ,  Matthew Truppo

IPC: C12N9/02

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.