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1.发明授权Measuring cell and measuring field comprising measuring cells of this type, use of a measuring and use of a measuring field 有权测量电池和测量领域包括测量这种类型的电池，使用测量和使用测量领域公开(公告)号：US07084641B2
公开(公告)日：2006-08-01
申请号：US10754909
申请日：2004-01-09
CPC分类号： G11C27/024 , G01N27/4148 , G01N33/48728
摘要： A measuring cell for recording an electrical potential of an analyte situated on the measuring cell. The measuring cell has a sensor, a layer arranged above the sensor and electrically insulating the analyte from the sensor, and an amplifier circuit connected to the sensor on a substrate and having an input stage containing a field-effect transistor or a bipolar transistor, the sensor being at least indirectly connected to a control terminal of the field-effect transistor or of the bipolar transistor. An operating point of the amplifier circuit is set by means of a voltage or a current applied at the control terminal of the field-effect transistor or of the bipolar transistor of the input stage of the amplifier circuit.
摘要翻译： 用于记录位于测量池上的分析物的电位的测量单元。 测量单元具有传感器，布置在传感器上方并将分析物与传感器电绝缘的层，以及连接到衬底上的传感器并具有包含场效应晶体管或双极晶体管的输入级的放大器电路， 传感器至少间接连接到场效应晶体管或双极晶体管的控制端子。 放大器电路的工作点通过施加在场效应晶体管的控制端或放大器电路的输入级的双极晶体管的电压或电流来设定。
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公开(公告)号：US20080036444A1
公开(公告)日：2008-02-14
申请号：US11663078
申请日：2005-09-01
CPC分类号： G01N27/3276
摘要： A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridisation between trap molecules and the particles for recording, has occurred.
摘要翻译： 公开了一种包括控制电路的传感器装置。 在至少一个实施例中，可以对至少一个传感器电极进行充电和/或放电，以及用于将所述至少一个电极的提供的电压与参考电压进行比较的比较器单元。 确定至少一个传感器电极的充电/放电所需的持续时间，由此，从所确定的持续时间确定是否发生了陷阱分子和用于记录的颗粒之间的杂交形式的传感器事件 。
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公开(公告)号：US20060289726A1
公开(公告)日：2006-12-28
申请号：US11450276
申请日：2006-06-12
申请人： Christian Paulus , Roland Thewes
发明人： Christian Paulus , Roland Thewes
IPC分类号： G06M7/00
CPC分类号： G01N27/3275 , H01L27/092
摘要： A circuit arrangement is disclosed. The circuit arrangement includes a substrate, at least one sensor array arranged on and/or in the substrate, and at least one operating circuit integrated on and/or in the substrate and serving for driving the at least one sensor array. The operating circuit and the sensor array are arranged in a manner spatially separate from one another.
摘要翻译： 公开了一种电路装置。 电路装置包括衬底，布置在衬底上和/或衬底中的至少一个传感器阵列，以及集成在衬底上和/或衬底中的至少一个操作电路，用于驱动至少一个传感器阵列。 操作电路和传感器阵列以空间上彼此分离的方式排列。
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4.发明申请Capacitative biosensor element and method for detecting hybridization events 审中-公开用于检测杂交事件的电容式生物传感器元件和方法公开(公告)号：US20060226030A1
公开(公告)日：2006-10-12
申请号：US10562040
申请日：2004-05-11
IPC分类号： G01F1/64 , G01N33/487
CPC分类号： G01N33/54346 , B01L3/5027 , C12Q1/6825 , C12Q1/6834 , G01N27/3276 , G01N33/5438
摘要： A sensor element is for detecting DNA single strands which are possibly contained in an analyte. The sensor element includes a substrate and at least two electrodes in and/or on the substrate. In a surface area of the substrate, catcher molecules are immobilized and are adapted to hybridize to DNA single strands that are possibly contained in an analyte. The DNA single strands include a label that has dielectric properties that are different from those of the analyte. The electrodes are coupled to a detection device for detecting a change in the capacitative portion of the impedance between the electrodes due to a label that is present in an area surrounding the electrodes as a result of the hybridization event.
摘要翻译： 传感器元件用于检测可能包含在分析物中的DNA单链。 传感器元件包括衬底和衬底中和/或上的至少两个电极。 在底物的表面区域中，捕获剂分子被固定并适于与可能包含在分析物中的DNA单链杂交。 DNA单链包括具有不同于分析物的介电性质的标记。 电极耦合到检测装置，用于由于杂交事件的结果，由于存在于电极周围的区域中的标签，用于检测电极之间的阻抗的电容部分的变化。
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5.发明授权Electronic circuit, sensor arrangement and method for processing a sensor signal 有权电子电路，传感器布置和处理传感器信号的方法公开(公告)号：US06922081B2
公开(公告)日：2005-07-26
申请号：US10399355
申请日：2001-10-16
申请人： Alexander Frey , Christian Paulus , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Roland Thewes
IPC分类号： G01N33/53 , G01D3/02 , G01N27/02 , G01N27/22 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N27/49 , G01N37/00 , H03K19/0175 , G01R27/26
CPC分类号： G01D3/02 , G01N27/3277
摘要： In a first phase a first sensor signal, essentially comprising the current offset signal of the sensor, is applied to the input of an electronic circuit. The first sensor signal is fed to a first signal path and stored therein. In a second phase a second sensor signal, comprising the current offset signal and a time-dependent measured signal, is applied to the input and the stored first sensor signal is fed to the input by means of the first signal path, such that essentially the time dependent measured signal is fed by means of a second signal path coupled to the input.
摘要翻译： 在第一阶段中，基本上包括传感器的当前偏移信号的第一传感器信号被施加到电子电路的输入。 第一传感器信号被馈送到第一信号路径并存储在其中。 在第二阶段，包括当前偏移信号和时间相关测量信号的第二传感器信号被施加到输入端，并且所存储的第一传感器信号通过第一信号路径馈送到输入端，使得基本上 时间相关测量信号通过耦合到输入的第二信号路径馈送。
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6.发明申请Event detection - apparatus and method for measuring the activity of neural netwoks 有权事件检测 - 用于测量神经网络活动的装置和方法公开(公告)号：US20050107893A1
公开(公告)日：2005-05-19
申请号：US10964560
申请日：2004-10-12
CPC分类号： A61B5/7264 , A61B5/04001 , A61B5/7203 , A61B5/7232 , A61B5/7282 , A61B2562/0209 , A61B2562/046 , G06N3/061
摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.
摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。
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公开(公告)号：US08702921B2
公开(公告)日：2014-04-22
申请号：US11019948
申请日：2004-12-21
申请人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N27/26
CPC分类号： G01N27/3276
摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.
摘要翻译： 一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘 从所述至少一个检测线。 在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条， 至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。 生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元， 将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。
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8.发明授权Planar sensor arrangement, sensor array and method for the production of a planar-sensor arrangement 有权平面传感器布置，传感器阵列和生产平面传感器装置的方法公开(公告)号：US07670557B2
公开(公告)日：2010-03-02
申请号：US11631380
申请日：2005-06-30
IPC分类号： G01N31/00
CPC分类号： G01N33/5438 , G01N27/02 , G01N27/3276
摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilized. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.
摘要翻译： 公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。 传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。 第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。 第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。 传感器元件还包括布线结构，通过该布线结构，传感器电极的至少一部分第一传感器电极的部分区域电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分 电耦合在一起。
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公开(公告)号：US07662341B2
公开(公告)日：2010-02-16
申请号：US10530882
申请日：2003-10-14
IPC分类号： G01N33/00
CPC分类号： G01N27/4145 , G01N33/48728
摘要： A sensor arrangement and method of operating the sensor arrangement are described. The sensor arrangement has sensor devices formed on or in a substrate and a calibration device for calibrating a respective sensor device. Each sensor device has an electrical signal converter which is a field-effect transistor (FET) having a gate terminal coupled to a sensor element that is coupled to the signal converter, a device that keeps constant the electrical voltage between source and drain terminals of the FET, and a device for detecting the value of the electric current flowing through the signal converter. The sensor element characteristically influences the electrical conductivity of the signal converter on account of a sensor event on the sensor element. The calibration device brings the gate region of the FET to an electrical calibration potential such that the electric current is independent of parameter fluctuations of the FET.
摘要翻译： 描述了传感器装置和操作传感器装置的方法。 传感器装置具有形成在基板上或基板中的传感器装置和用于校准相应传感器装置的校准装置。 每个传感器装置具有电信号转换器，该电信号转换器是具有耦合到耦合到信号转换器的传感器元件的栅极端子的场效应晶体管（FET），保持恒定的源极和漏极端子之间的电压的装置 FET和用于检测流过信号转换器的电流值的装置。 传感器元件由于传感器元件上的传感器事件而特征地影响信号转换器的电导率。 校准装置使FET的栅极区域达到电校准电位，使得电流与FET的参数波动无关。
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10.发明授权Biosensor circuit and sensor array consisting of a plurality of said biosensor circuits and biosensor array 有权由多个所述生物传感器电路和生物传感器阵列组成的生物传感器电路和传感器阵列公开(公告)号：US07019305B2
公开(公告)日：2006-03-28
申请号：US10821803
申请日：2004-04-08
IPC分类号： G01N27/416
CPC分类号： H03F3/45188 , G01N27/4145 , G01N33/4836 , H03F2203/45352
摘要： Biosensor circuit arrangement including a substrate, a sensor element formed in or on a surface region of the substrate with a physical parameter, which is coupled to a substance to be examined, the type of coupling having a resistive component, the sensor element having an electrically conductive sensor electrode that is coupled to the substance to be examined, the sensor element having a measuring transistor the gate terminal of which is coupled to the electrically conductive sensor electrode, and the physical parameter being the threshold voltage of the measuring transistor, and a calibration device formed in or on the substrate, the calibration device being set up such that it is used to at least partly compensate for an alteration of the value of the physical parameter of the sensor element.
摘要翻译： 生物传感器电路装置，其包括衬底，形成在衬底的表面区域中或其上的具有物理参数的传感器元件，该物理参数耦合到待检查物质，具有电阻部件的耦合类型，所述传感器元件具有电 导电传感器电极，其耦合到待检查的物质，传感器元件具有测量晶体管，栅极端子耦合到导电传感器电极，物理参数是测量晶体管的阈值电压，并且校准 所述校准装置设置成使得其被用于至少部分地补偿所述传感器元件的物理参数的值的变化。
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