公开(公告)号：US06922081B2

公开(公告)日：2005-07-26

申请号：US10399355

申请日：2001-10-16

申请人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

IPC分类号： G01N33/53 ,  G01D3/02 ,  G01N27/02 ,  G01N27/22 ,  G01N27/327 ,  G01N27/333 ,  G01N27/414 ,  G01N27/416 ,  G01N27/49 ,  G01N37/00 ,  H03K19/0175 ,  G01R27/26

CPC分类号： G01D3/02 ,  G01N27/3277

摘要： In a first phase a first sensor signal, essentially comprising the current offset signal of the sensor, is applied to the input of an electronic circuit. The first sensor signal is fed to a first signal path and stored therein. In a second phase a second sensor signal, comprising the current offset signal and a time-dependent measured signal, is applied to the input and the stored first sensor signal is fed to the input by means of the first signal path, such that essentially the time dependent measured signal is fed by means of a second signal path coupled to the input.

摘要翻译： 在第一阶段中，基本上包括传感器的当前偏移信号的第一传感器信号被施加到电子电路的输入。 第一传感器信号被馈送到第一信号路径并存储在其中。 在第二阶段，包括当前偏移信号和时间相关测量信号的第二传感器信号被施加到输入端，并且所存储的第一传感器信号通过第一信号路径馈送到输入端，使得基本上 时间相关测量信号通过耦合到输入的第二信号路径馈送。

公开(公告)号：US08702921B2

公开(公告)日：2014-04-22

申请号：US11019948

申请日：2004-12-21

申请人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N27/26

CPC分类号： G01N27/3276

摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.

摘要翻译： 一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘 从所述至少一个检测线。 在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条， 至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。 生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元， 将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

公开(公告)号：US07670557B2

公开(公告)日：2010-03-02

申请号：US11631380

申请日：2005-06-30

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N31/00

CPC分类号： G01N33/5438 ,  G01N27/02 ,  G01N27/3276

摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilized. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.

摘要翻译： 公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。 传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。 第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。 第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。 传感器元件还包括布线结构，通过该布线结构，传感器电极的至少一部分第一传感器电极的部分区域电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分 电耦合在一起。

公开(公告)号：US20050068046A1

公开(公告)日：2005-03-31

申请号：US10913706

申请日：2004-08-05

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N27/416 ,  G01N27/02 ,  G01N27/327 ,  G01N27/403 ,  G01N37/00 ,  G01R27/26

CPC分类号： G01N27/3276

摘要： Circuit arrangement having a sensor electrode, a first circuit unit, which is electrically coupled to the sensor electrode, and a second circuit unit, which has a first capacitor. The first circuit unit holds an electrical potential of the sensor electrode in a predetermined first reference range around a predetermined electrical desired potential by coupling the first capacitor and the sensor electrode such that there is a matching of their electrical potentials. If the second circuit unit detects the electrical potential of the first capacitor being outside a second reference range, the second circuit unit brings the first capacitor to a first electrical reference potential.

摘要翻译： 具有传感器电极，电耦合到传感器电极的第一电路单元和具有第一电容器的第二电路单元的电路装置。 第一电路单元通过将第一电容器和传感器电极耦合使得存在与它们的电位相匹配的方式，将传感器电极的电位保持在预定的电气期望电位周围的预定的第一参考范围内。 如果第二电路单元检测到第一电容器的电位在第二参考范围之外，则第二电路单元将第一电容器引入第一电参考电位。

公开(公告)号：US07123029B2

公开(公告)日：2006-10-17

申请号：US10913706

申请日：2004-08-05

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01R27/26 ,  G01N27/26

CPC分类号： G01N27/3276

摘要： Circuit arrangement having a sensor electrode, a first circuit unit, which is electrically coupled to the sensor electrode, and a second circuit unit, which has a first capacitor. The first circuit unit holds an electrical potential of the sensor electrode in a predetermined first reference range around a predetermined electrical desired potential by coupling the first capacitor and the sensor electrode such that there is a matching of their electrical potentials. If the second circuit unit detects the electrical potential of the first capacitor being outside a second reference range, the second circuit unit brings the first capacitor to a first electrical reference potential.

摘要翻译： 具有传感器电极，电耦合到传感器电极的第一电路单元和具有第一电容器的第二电路单元的电路装置。 第一电路单元通过将第一电容器和传感器电极耦合使得存在与它们的电位相匹配的方式，将传感器电极的电位保持在预定的电气期望电位周围的预定的第一参考范围内。 如果第二电路单元检测到第一电容器的电位在第二参考范围之外，则第二电路单元将第一电容器引入第一电参考电位。

公开(公告)号：US20050247559A1

公开(公告)日：2005-11-10

申请号：US11019948

申请日：2004-12-21

申请人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N33/53 ,  G01N27/02 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N33/487 ,  G01N37/00 ,  G01N27/26

CPC分类号： G01N27/3276

摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.

摘要翻译： 一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘 从所述至少一个检测线。 在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条， 至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。 生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元， 将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

公开(公告)号：US20050194250A1

公开(公告)日：2005-09-08

申请号：US11002736

申请日：2004-12-02

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： C12M1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N27/02

CPC分类号： C12M1/00 ,  C12Q1/6837 ,  G01N1/00 ,  G01N27/3276 ,  C12Q2565/607

摘要： Sensor arrangement, set up as an integrated circuit, having a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal, a detection device, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

摘要翻译： 设置为集成电路的传感器布置，具有衬底，布置在衬底上的至少三个传感器电极，使得在将导电物质引入传感器装置的操作状态下，传感器电极耦合到一个 另一个通过导电物质捕获固定在传感器电极的至少一部分上的分子，其中待检测的分子可与捕获分子杂交;控制电路，用于将第一电信号施加到所选择的传感器电极，同时 将第二电信号施加到至少两个其它传感器电极，所述第一电信号是第一时间可变电信号和/或所述第二电信号是第二时间可变电信号，所述检测装置被设置为 在第一操作状态下，将参考液体引入到传感器中 在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的参考值，并且在第二操作状态中，分析物可能 将要检测的分子引入传感器装置中，在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的传感器值， 评估电路，其基于参考值和传感器值确定在所选择的传感器电极处是否发生杂交事件。

公开(公告)号：US07914655B2

公开(公告)日：2011-03-29

申请号：US10556731

申请日：2004-05-11

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N27/327 ,  G01R19/12

CPC分类号： G01R19/252 ,  C12Q1/6825 ,  G01N27/3276

摘要： A circuit arrangement, an electrochemical sensor, a sensor arrangement, and a method for processing a current signal provided by a sensor electrode are disclosed. The circuit arrangement includes a sensor electrode, a first circuit unit, electrically coupled to the sensor electrode and a second circuit unit, including a first capacitor, whereby the first circuit arrangement is embodied to hold the electrical potential of the sensor electrode in a given first reference range about a set electrical potential and, when the sensor electrode potential falls outside the first reference range, the first capacitor and the sensor electrode are coupled such that a matching of the electrical potentials is possible. The second circuit unit is embodied such that, when the electrical potential of the first capacitor falls outside a second reference range, this event is detected and the first capacitor brought to a first electrical reference potential.

摘要翻译： 公开了电路装置，电化学传感器，传感器装置和用于处理由传感器电极提供的电流信号的方法。 电路装置包括传感器电极，电耦合到传感器电极的第一电路单元和包括第一电容器的第二电路单元，由此第一电路装置被实施为将传感器电极的电势保持在给定的第一 参考范围关于设定的电位，并且当传感器电极电位落在第一参考范围之外时，第一电容器和传感器电极被耦合，使得电位的匹配是可能的。 实施第二电路单元，使得当第一电容器的电位落在第二参考范围之外时，检测到该事件，并将第一电容器带到第一电参考电位。

公开(公告)号：US07756560B2

公开(公告)日：2010-07-13

申请号：US11002736

申请日：2004-12-02

申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： A61B5/05

CPC分类号： C12M1/00 ,  C12Q1/6837 ,  G01N1/00 ,  G01N27/3276 ,  C12Q2565/607

摘要： Sensor arrangement having capture molecules immobilized on any of three sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules; a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes; a detection device, wherein in a first operating state a reference liquid is introduced into the sensor arrangement and a reference value of an electrical signal is detected at the selected sensor electrode, and in a second operating state an analyte possibly having molecules to be detected is introduced into the sensor arrangement and a sensor value of the electrical signal is detected at the selected sensor electrode; and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

摘要翻译： 传感器布置，其具有固定在三个传感器电极中的任一个上的捕获分子，其中待检测的分子可与捕获分子杂交; 控制电路，用于将第一电信号施加到所选择的传感器电极，并同时向至少两个其它传感器电极施加第二电信号; 检测装置，其中在第一操作状态下，将参考液体引入所述传感器装置，并且在所选择的传感器电极处检测到电信号的参考值，并且在第二操作状态下，可能具有待检测分子的分析物是 引入到传感器装置中，并且在所选择的传感器电极处检测电信号的传感器值; 以及评估电路，其基于参考值和传感器值确定在所选择的传感器电极处是否发生杂交事件。

公开(公告)号：US20070181424A1

公开(公告)日：2007-08-09

申请号：US11631380

申请日：2005-06-30

申请人： Alexander FREY ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Alexander FREY ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01N33/487

CPC分类号： G01N33/5438 ,  G01N27/02 ,  G01N27/3276

摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilised. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.

摘要翻译： 公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。 传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。 第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。 第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。 传感器元件还包括布线结构，通过该布线结构，第一传感器电极的传感器电极部分区域的至少一部分电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分 电耦合在一起。