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公开(公告)号：US07906563B2
公开(公告)日：2011-03-15
申请号：US12292929
申请日：2008-12-01
Applicant: Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
Inventor： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
IPC: C08F290/06 , C07F7/04
Abstract: A polysiloxane-based prepolymer of a three-dimensional network structure produced by hydrolysis-condensation of a first mixture having a tetra-alkoxysilane compound, an ethylenically unsaturated organosiloxane monomer, and a hydrophilic silicon-containing polyfunctional monomer. A hydrogel is prepared by polymerizing a second mixture having the aforesaid polysiloxane-based prepolymer, an acrylated silicon-containing monomer, and an ethylenically unsaturated hydrophilic monomer.
Abstract translation: 通过具有四烷氧基硅烷化合物，烯键式不饱和有机硅氧烷单体和亲水性含硅多官能单体的第一混合物的水解缩合制备的三维网状结构体的聚硅氧烷类预聚物。 通过聚合具有上述聚硅氧烷类预聚物，丙烯酸酯化含硅单体和烯属不饱和亲水单体的第二混合物制备水凝胶。
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公开(公告)号：US20090170976A1
公开(公告)日：2009-07-02
申请号：US12292929
申请日：2008-12-01
Applicant: Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
Inventor： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
Abstract: A polysiloxane-based prepolymer of a three-dimensional network structure produced by hydrolysis-condensation of a first mixture having a tetra-alkoxysilane compound, an ethylenically unsaturated organosiloxane monomer, and a hydrophilic silicon-containing polyfunctional monomer. A hydrogel is prepared by polymerizing a second mixture having the aforesaid polysiloxane-based prepolymer, an acrylated silicon-containing monomer, and an ethylenically unsaturated hydrophilic monomer.
Abstract translation: 通过具有四烷氧基硅烷化合物，烯键式不饱和有机硅氧烷单体和亲水性含硅多官能单体的第一混合物的水解缩合制备的三维网状结构体的聚硅氧烷类预聚物。 通过聚合具有上述聚硅氧烷类预聚物，丙烯酸酯化含硅单体和烯属不饱和亲水单体的第二混合物制备水凝胶。
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公开(公告)号：US08492513B2
公开(公告)日：2013-07-23
申请号：US13273407
申请日：2011-10-14
Applicant: Chih-Ta Lee , Ching-Ping Huang , Yi-Hsuan Chang , Ken-Yuan Chang
Inventor： Chih-Ta Lee , Ching-Ping Huang , Yi-Hsuan Chang , Ken-Yuan Chang
IPC: C08J7/12
Abstract: The present invention provides a method for producing a silicone hydrogel having a high water content. The method comprises the following steps: (a) polymerizing a monomer mixture to form the silicone hydrogel, wherein the monomer mixture comprises at least one silicon-containing monomer and at least one ionic monomer; and (b) placing the silicone hydrogel in an alkaline solution for at least 20 minutes, wherein the alkaline solution has a pH not less than 7.5 and the ionic monomer is present in an amount not less than 0.7 wt % based on the total dry weight of the silicone hydrogel.
Abstract translation: 本发明提供一种水含量高的硅氧烷水凝胶的制造方法。 该方法包括以下步骤：（a）聚合单体混合物以形成硅氧烷水凝胶，其中单体混合物包含至少一种含硅单体和至少一种离子单体; 和（b）将硅氧烷水凝胶置于碱性溶液中至少20分钟，其中碱性溶液的pH值不低于7.5，离子单体的存在量相对于总干重为0.7重量％ 的硅酮水凝胶。
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公开(公告)号：US20120214898A1
公开(公告)日：2012-08-23
申请号：US13273395
申请日：2011-10-14
Applicant: CHIH-TA LEE , Ching-Ping Huang , Yi-Hsuan Chang , Ken-Yuan Chang
Inventor： CHIH-TA LEE , Ching-Ping Huang , Yi-Hsuan Chang , Ken-Yuan Chang
IPC: C08L43/04
CPC classification number: C08F230/08 , C08F220/06 , C08F220/20 , C08F226/10 , C08G77/20
Abstract: The present invention provides a silicone hydrogel comprising a reaction product of a monomer mixture for forming the silicone hydrogel and water, wherein the water is present in an amount not less than 50 wt % based on the total weight of the silicone hydrogel. The monomer mixture comprises at least one silicon-containing monomer and at least one ionic monomer, wherein the ionic monomer is present in an amount not less than 0.7 wt % based on the total dry weight of the silicone hydrogel. The present invention also provides ocular articles made from the silicone hydrogel.
Abstract translation: 本发明提供了一种硅水凝胶，其包含用于形成硅氧烷水凝胶和水的单体混合物的反应产物，其中水的含量不得少于硅氧水凝胶总重量的50wt％。 单体混合物包含至少一种含硅单体和至少一种离子单体，其中离子单体的存在量相对于硅酮水凝胶的总干重为0.7重量％以上。 本发明还提供由硅酮水凝胶制成的眼用物品。
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公开(公告)号：US20110129437A1
公开(公告)日：2011-06-02
申请号：US12956179
申请日：2010-11-30
Applicant: Ying-nan TSAI , Ken-Yuan Chang , Fa Chen Chi , Po-Yang Chen , Cheng-Tar Wu
Inventor： Ying-nan TSAI , Ken-Yuan Chang , Fa Chen Chi , Po-Yang Chen , Cheng-Tar Wu
IPC: A61K31/785 , A61P7/02 , C08F222/40 , C08G71/04
CPC classification number: C08G18/7671 , A61K31/785 , C08G18/3829 , C08G18/4833 , C08G18/6685 , C08G18/755 , C08G18/758
Abstract: A platelet adhesion-resistant material is provided, which includes polytriuret-urethane consisting essentially of repeating structural units of formulae (I) to (III) in a random order, in which when the total number of the three repeating structural units in the polytriuret-urethane is 100, the number of the repeating structural units (I) is about 5 to about 50: in which each R independently represents a C2-C16 alkylene group, a C6-C30 aromatic group, a C6-C30 alicyclic group; n is an integer of 2 to 16; and R1 represents —(OCmH2m)p, in which m is an integer of 2 to 5, and p is an integer of 3 to 150.
Abstract translation: 提供了一种抗血小板粘合性材料，其包括基本上由随机顺序的式（I）至（III）的重复结构单元组成的多核苷酸 - 氨基甲酸酯，其中当多萜类化合物的三个重复结构单元的总数， 氨基甲酸酯为100，重复结构单元（I）的数量为约5至约50：其中各R独立地表示C2-C16亚烷基，C6-C30芳族基团，C6-C30脂环族基团; n为2〜16的整数。 并且R 1表示 - （OC m H 2n）p，其中m为2至5的整数，p为3至150的整数。
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Patent Agency Ranking
公开(公告)号：US06436426B1
公开(公告)日：2002-08-20
申请号：US09870370
申请日：2001-05-30
Applicant: Chun-Jen Liao , Chin-Fu Chen , Jui-Hsiang Chen , Ken-Yuan Chang , Yure-Ru Lin , Shu-Fang Chiang
Inventor： Chun-Jen Liao , Chin-Fu Chen , Jui-Hsiang Chen , Ken-Yuan Chang , Yure-Ru Lin , Shu-Fang Chiang
IPC: A61F200
CPC classification number: C08J9/26 , C08J2201/0444 , C08J2201/046 , C08J2201/0542
Abstract: The present invention provides a process for producing porous polymer materials. In the present invention, a polymer material and a soluble material are mixed in their solid states. The surface of the polymer material is partially dissolved and fused by introducing a solvent. The present invention makes use of a pressure difference while introducing a non-solvent into the polymer material to solidify and resolve the solved polymer material. Then, a substantial amount of water is used to wash the inside soluble material out. Therefore, the porous polymer materials with high porosity and interconnecting pores inside the materials are produced massively and rapidly.
Abstract translation: 本发明提供一种生产多孔聚合物材料的方法。 在本发明中，将聚合物材料和可溶性材料以其固态混合。 通过引入溶剂将聚合物材料的表面部分溶解并熔融。 本发明利用压力差，同时将非溶剂引入聚合物材料中以固化和分解溶解的聚合物材料。 然后，大量的水被用来洗涤内部的可溶性材料。 因此，材料内部具有高孔隙率和互连孔的多孔聚合物材料大量且快速地产生。
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公开(公告)号：US20120316314A1
公开(公告)日：2012-12-13
申请号：US13592758
申请日：2012-08-23
Applicant: Jo-Wei Huang , Mei-Ting Fan Chiang , Ken-Yuan Chang
Inventor： Jo-Wei Huang , Mei-Ting Fan Chiang , Ken-Yuan Chang
IPC: C08G63/685 , D01D5/06
Abstract: A water-insoluble polyglutamic acid (PGA) fiber and a preparation method thereof are provided. In the preparation method, the PGA is cross-linked by a cross-linking agent and then passes through a spinning nozzle to form PGA fibers. Therefore, the highly water-absorbing PGA, which cannot be spun by conventional methods, can be spun to form PGA fibers and maintain the high water-absorption ability.
Abstract translation: 提供了水不溶性聚谷氨酸（PGA）纤维及其制备方法。 在制备方法中，PGA通过交联剂交联，然后通过纺丝喷嘴形成PGA纤维。 因此，通过常规方法不能纺丝的高吸水性PGA可以纺丝以形成PGA纤维并保持高的吸水能力。
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公开(公告)号：US08273278B2
公开(公告)日：2012-09-25
申请号：US12757288
申请日：2010-04-09
Applicant: Jo-Wei Huang , Mei-Ting Fan Chiang , Ken-Yuan Chang
Inventor： Jo-Wei Huang , Mei-Ting Fan Chiang , Ken-Yuan Chang
Abstract: A water-insoluble polyglutamic acid (PGA) fiber and a preparation method thereof are provided. In the preparation method, the PGA is cross-linked by a cross-linking agent and then passes through a spinning nozzle to form PGA fibers. Therefore, the highly water-absorbing PGA, which cannot be spun by conventional methods, can be spun to form PGA fibers and maintain the high water-absorption ability.
Abstract translation: 提供了水不溶性聚谷氨酸（PGA）纤维及其制备方法。 在制备方法中，PGA通过交联剂交联，然后通过纺丝喷嘴形成PGA纤维。 因此，通过常规方法不能纺丝的高吸水性PGA可以纺丝以形成PGA纤维并保持高的吸水能力。
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公开(公告)号：US20050113531A1
公开(公告)日：2005-05-26
申请号：US10721877
申请日：2003-11-26
Applicant: Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
Inventor： Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
CPC classification number: C08G63/664 , A61K9/0024 , A61L24/0042 , A61L31/06 , A61L31/148 , C08G2261/126 , C08L67/04
Abstract: A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(═O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
Abstract translation: 下式的热敏共聚物; 被披露 其中R 1是氢或-C（-O）-R 2; R 2是被官能团取代或未取代的C 7-30烷基; R 3是氢或C 1-6烷基; 并且x，y或z分别是大于0的整数。这里公开的热敏共聚物通过注射容易地植入人体。 生物降解性大大提高，共聚物的细胞毒性低。
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公开(公告)号：US06323022B1
公开(公告)日：2001-11-27
申请号：US09346101
申请日：1999-07-01
Applicant: King-Ming Chang , Long-Shuenn Jean , Yu-Tai Liu , Chun-Chieh Chen , Ken-Yuan Chang , Shu-Fang Chiang
Inventor： King-Ming Chang , Long-Shuenn Jean , Yu-Tai Liu , Chun-Chieh Chen , Ken-Yuan Chang , Shu-Fang Chiang
IPC: C12M136
Abstract: A cell-cultivating device includes a plurality of culture tanks and a driving device. The culture tanks communicate with each other and have culture medium inside. The driving device forces the culture medium to flow between the culture tanks so as to vertically oscillate medium levels in the culture tanks.
Abstract translation: 细胞培养装置包括多个培养罐和驱动装置。 文化池相互通信，内部有培养基。 驱动装置迫使培养基在培养罐之间流动，以便在培养罐中垂直振荡中等水平。
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