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    Nano- and mesosized particles comprising an inorganic core, process and applications thereof
    2.
    发明授权
    Nano- and mesosized particles comprising an inorganic core, process and applications thereof 有权
    包含无机核的纳米和中尺寸颗粒，其工艺和应用

    公开(公告)号：US08377469B2

    公开(公告)日：2013-02-19

    申请号：US11813311

    申请日：2006-01-02

    Applicant: Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    Inventor： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    IPC: A61K9/127

    CPC classification number: A61K9/1272 ,  A61K9/127 ,  A61K9/1277

    Abstract: Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.

    Abstract translation: 由包含至少一种无机化合物和/或金属的两亲物和核心的脂质层组成的纳米和中尺寸颗粒的制备方法，包括：（i）在普通溶剂中溶解至少一种自聚集的两亲物 与所述无机化合物或金属的至少一种无机，有机金属或金属有机前体; 和（ii）将所得溶液注入水溶液中或干燥所得溶液并对其进行再水化，以形成其中前体被两亲物包封并在其中转化为所述无机化合物的颗粒， /或金属固体形式。

    Rotor for a threshing system of an agricultural combine and method of making the same
    3.
    发明申请
    Rotor for a threshing system of an agricultural combine and method of making the same 有权
    转子为农业联合打谷系统和制作方法

    公开(公告)号：US20080234018A1

    公开(公告)日：2008-09-25

    申请号：US11726007

    申请日：2007-03-20

    Applicant: Craig E. Murray ,  Charles Linder ,  Robert A. Matousek ,  Mark S. Epperly

    Inventor： Craig E. Murray ,  Charles Linder ,  Robert A. Matousek ,  Mark S. Epperly

    IPC: A01F12/18

    CPC classification number: A01F12/18 ,  A01F12/22 ,  Y10T29/49908

    Abstract: A rotor for a threshing system of an agricultural combine and method for making the same, including a body of simplified, three part press fit construction including an inlet segment, a main body segment having threshing elements therearound, and a bulkhead to be connected to a drive mechanism. The inlet segment, main body segment and bulkhead are configured so as to facilitate press fit assembly thereof concentric about a rotational axis about which the rotor will be rotated during operation, while also minimizing eccentricities of those components. As a result, the manufacture of the rotor is simplified by the elimination of the need for an internal skeleton structure and associated welds and/or fasteners.

    Abstract translation: 一种用于农业组合的脱粒系统的转子及其制造方法，包括简化的三部分压配合结构的主体，包括入口段，具有脱粒元件的主体段以及与其连接的隔板 驱动机构。 入口段，主体段和隔板被构造成便于其在转动轴线周围同心的压配合组件，转子将在其周围旋转，同时还使这些部件的偏心度最小化。 结果，通过消除对内部骨架结构和相关联的焊接和/或紧固件的需要，简化了转子的制造。

    Encapsulated essential oils
    5.
    发明申请
    Encapsulated essential oils 有权
    封闭精油

    公开(公告)号：US20070042182A1

    公开(公告)日：2007-02-22

    申请号：US10556633

    申请日：2004-05-06

    Applicant: Arie Markus ,  Charles Linder

    Inventor： Arie Markus ,  Charles Linder

    IPC: B32B9/00

    CPC classification number: A01N25/28 ,  A01N65/00 ,  A01N65/06 ,  A01N65/28 ,  B01J13/16 ,  Y02A50/351 ,  Y10T428/2984 ,  A01N2300/00

    Abstract: The invention provides a process for the preparation of essential oil microcapsules comprising dissolving a di- or polyisocyanate into an essential oil, emulsifying the resulting mixture in an aqueous solution containing a di- or polyamine, and or a di or polyhydroxy compound to effect encapsulation of said essential oil through interfacial polymerization, whereby there is formed a polyurea and/orpolyurethane film around the essential oil droplets which film enhances the stability of said essential oil, reduces its evaporation rate and controls its release rate when applied to a substrate.

    Abstract translation: 本发明提供了一种制备精油微胶囊的方法，其包括将二异氰酸酯或多异氰酸酯溶解在精油中，将所得混合物乳化在含有二胺或多胺，或二或多羟基化合物的水溶液中以使包封 通过界面聚合说明精油，由此在精油液滴周围形成聚脲和/或聚氨酯膜，所述薄膜增强了所述精油的稳定性，降低了其蒸发速率并且在施加到基材上时控制其释放速率。

    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
    6.
    发明申请
    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting 有权
    两性化合物和囊泡脂质体用于器官特异性药物靶向

    公开(公告)号：US20060039962A1

    公开(公告)日：2006-02-23

    申请号：US10497705

    申请日：2002-12-04

    Applicant: Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg

    Inventor： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg

    IPC: A61K9/127 ,  C07C237/12

    CPC classification number: C07D401/04 ,  A61K9/1272 ,  C07C219/06 ,  C07C233/36 ,  C07C235/28 ,  C07C237/10 ,  C07D303/46 ,  C07H7/00 ,  C07H15/10 ,  C07H15/26

    Abstract: An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

    Abstract translation: 提供能够形成囊泡或脂质体的两亲化合物，所述两亲化合物具有至少一个含有选择性可切割基团或部分的头基，例如胆碱或苯丙氨酸衍生物的残基，以及至少一个位于所述 头组和/或其附近。 可切割基团或部分在选择性条件下被切割，包括化学，物理或生物环境的变化，并且优选在诸如脑或血液的生物环境中酶促切割。 由所述两亲性化合物制成的囊泡或脂质体适于将治疗物质或诊断剂特异性递送至靶器官或组织，或用于递送用于基因治疗的核酸。

    Feeder chain wear strip
    7.
    发明授权
    Feeder chain wear strip 有权
    给料链条带

    公开(公告)号：US06968942B2

    公开(公告)日：2005-11-29

    申请号：US10211823

    申请日：2002-08-02

    Applicant: Charles Linder

    Inventor： Charles Linder

    IPC: B65G19/24 ,  B65G19/00

    CPC classification number: B65G19/24 ,  A01F12/10 ,  B65G2201/04

    Abstract: A wear strip easily mountable on an outer surface of a support member or structure of a feeder of an agricultural combine, for preventing wear of the support member and a feeder chain movable thereover. The wear strip includes an elongate body of a molded plastics material having a longitudinal extending side to be positioned in facing relation to the chain and an opposite longitudinally extending mounting side to be mounted on the support member, the mounting side including at least one molded plastics mounting tab extending outwardly therefrom in a position for insertion into at least one hole through the support member, respectively. The mounting tab includes at least one resiliently displaceable or biasable projection spaced from the body and oriented so as to extend in a predetermined direction from the mounting tab, the projection defining a locking portion or detent for cooperatively engaging an edge of the hole or an inner surface of the support member for holding the tab in the hole with the mounting surface of the body in abutting relation to the outer surface of the support member while allowing limited longitudinal movement of the body relative to the support member.

    Abstract translation: 一种耐磨条，其易于安装在农业组合的进料器的支撑构件或结构的外表面上，用于防止支撑构件的磨损和可在其上移动的进料链。 该耐磨条包括一个成型塑料材料的细长体，其具有纵向延伸的侧面，以与链条相面对的方式定位，并且相对的纵向延伸的安装侧被安装在支承件上，安装侧包括至少一个模制塑料 安装翼片从其中向外延伸到分别穿过支撑构件插入至少一个孔的位置。 所述安装翼片包括至少一个与所述主体间隔开的可弹性位移或可偏置的突出部并被定向成从所述安装突片沿预定方向延伸，所述突出部限定用于与所述孔的边缘配合地接合的锁定部分或棘爪， 支撑构件的表面用于将突片保持在孔中，其中主体的安装表面与支撑构件的外表面邻接，同时允许主体相对于支撑构件的有限的纵向移动。

    Chargedasymmetric mosaic membrances
    8.
    发明授权
    Chargedasymmetric mosaic membrances 失效
    带电对称马赛克膜

    公开(公告)号：US5304307A

    公开(公告)日：1994-04-19

    申请号：US801859

    申请日：1991-12-03

    Applicant: Charles Linder ,  Mara Nemas ,  Mordechai Perry ,  Reuven Ketraro

    Inventor： Charles Linder ,  Mara Nemas ,  Mordechai Perry ,  Reuven Ketraro

    IPC: B01D61/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/14 ,  B01D71/82 ,  B01D13/00

    CPC classification number: B01D67/0093 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/141 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2323/30 ,  B01D2325/022 ,  B01D2325/20

    Abstract: The present invention relates to semipermeable mosaic polymer membranes of asymmetric structure and with a macroscopic distribution of the mosaic-forming anionic and cationic charges (sites). The membranes can be prepared by casting a polymer solution of an optionally charged matrix-forming polymer and at least one precursor polymer, incompatible with the matrix-forming polymer, in a selected solvent, into a film, forming a skin on one side of the film, precipitating the skinned film to form the asymmetric membrane and charging it by chemical reactions to introduce or complete their mosaic structure. These membranes have good permeability for electrolytes, such as salts of mono- or polyvalent inorganic acids, while retaining low molecular weight organic solutes.

    Abstract translation: 本发明涉及不对称结构的半透性镶嵌聚合物膜和马赛克形成阴离子和阳离子电荷（位点）的宏观分布。 膜可以通过将任选带电的基质形成聚合物的聚合物溶液和在选定的溶剂中与基质形成聚合物不相容的至少一种前体聚合物浇铸成膜，从而在 膜，沉淀皮膜以形成不对称膜，并通过化学反应进行充电以引入或完成其镶嵌结构。 这些膜对于电解质具有良好的渗透性，例如单价或多价无机酸的盐，同时保留低分子量的有机溶质。

    Process and device for separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis
    9.
    发明授权
    Process and device for separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis 失效
    通过强制流膜电泳分离电荷充电的大分子化合物的方法和装置

    公开(公告)号：US5087338A

    公开(公告)日：1992-02-11

    申请号：US435837

    申请日：1989-11-14

    Applicant: Mordechai Perry ,  Jack Gilron ,  Reuven Ketraro ,  Charles Linder

    Inventor： Mordechai Perry ,  Jack Gilron ,  Reuven Ketraro ,  Charles Linder

    IPC: B01D57/02 ,  C07K1/24 ,  C07K1/26 ,  C07K1/28 ,  C07K14/76 ,  G01N27/447

    CPC classification number: G01N27/44769 ,  B01D57/02 ,  C07K1/24 ,  C07K1/26

    Abstract: A process and apparatus for the continuous separation of electrically charged macromolecular compounds, such as proteins, by forced-flow membrane electrophoresis is provided.Said process is conducted in an electrophoretic cell comprising a membrane compartment, divided by a micro- or ultrafiltration membrane into a feed and permeate cell, and electrode compartments being partitioned from the membrane compartment with ion-exchange membranes, which are impermeable to the macromolecular compounds, and have virtually no permeability to salts.The electrophoretic process comprises the steps of recycling a mixed solution of the charged compounds which are dissolved in a separation buffer through the feed cell, subjecting of the solution to a pressure-driven membrane separation, applying an electric field across the membranes and the solution to cause electrophoretic migration of the charged compound and to separate them, and withdrawing the charged compounds thus separated.The process achieves separation of charged compounds having differences of their isoelectric points in a range of as low as 0.1 to 0.2. The process is very useful to remove charged contaminants from the desired compounds.

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