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公开(公告)号：US20240277683A1
公开(公告)日：2024-08-22
申请号：US18394624
申请日：2023-12-22
申请人： CTXT PTY LTD
发明人： Paul Anthony Stupple , H. Rachel Lagiakos , Richard Charles Foitzik , Michelle Ang Camerino , George Nikolakopoulos , Ylva Elisabet Bergman Bozikis , Wilhelmus Johannes Antonius Kersten , Scott Raymond Walker , Jonathan Grant Hubert
IPC分类号： A61K31/4439 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K45/06
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof:
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公开(公告)号：US20170283407A1
公开(公告)日：2017-10-05
申请号：US15508063
申请日：2015-09-03
申请人： CTXT PTY LTD
IPC分类号： C07D413/14 , C07D405/12 , C07D413/12 , C07D401/14 , C07D217/04 , C07D401/12
CPC分类号： C07D413/14 , C07D217/04 , C07D231/12 , C07D239/42 , C07D271/10 , C07D295/192 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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3.发明授权公开(公告)号：US10005792B2
公开(公告)日：2018-06-26
申请号：US15508074
申请日：2015-09-03
申请人： CTXT PTY LTD
发明人： Ylva Elisabet Bergman , Romina Lessene , Danny Ganame , Richard Charles Foitzik , Benjamin Joseph Morrow , Michelle Ang Camerino , Scott Raymond Walker , H. Rachel Lagiakos , John Feutrill , Paul Anthony Stupple
IPC分类号： C07D207/12 , C07D209/44 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/76 , C07D213/81 , C07D213/82 , C07D217/06 , C07D217/12 , C07D231/14 , C07D231/20 , C07D231/56 , C07D235/08 , C07D271/08 , C07D271/10 , C07D261/18 , C07D277/56 , C07D277/68 , C07D265/30 , C07D265/34 , C07D401/04 , C07D401/12 , C07D413/04 , C07D451/02 , C07D451/14 , C07D491/08 , C07D491/107 , C07C233/78 , C07C235/42 , C07C235/60 , C07D295/192
CPC分类号： C07D491/107 , C07C233/78 , C07C235/42 , C07C235/50 , C07C235/60 , C07C311/08 , C07C2602/06 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/76 , C07D213/81 , C07D213/82 , C07D217/06 , C07D231/12 , C07D231/14 , C07D231/20 , C07D231/56 , C07D235/08 , C07D261/18 , C07D265/30 , C07D265/34 , C07D271/08 , C07D271/10 , C07D277/56 , C07D277/68 , C07D295/185 , C07D295/192 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/04 , C07D451/02 , C07D451/14 , C07D491/08
摘要： A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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公开(公告)号：US20220153710A1
公开(公告)日：2022-05-19
申请号：US17392356
申请日：2021-08-03
申请人： CTXT PTY LTD
发明人： H. Rachel Lagiakos , Benjamin Joseph Morrow , Richard Charles Foitzik , Catherine Fae Hemley , Michelle Ang Camerino , Paul Anthony Stupple , Ylva Elisabet Bergman Bozikis , Scott Raymond Walker
IPC分类号： C07D261/20 , C07D413/10 , C07D413/12 , C07D417/12
摘要： A compound of formula (I), or a pharmaceutical salt thereof:
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公开(公告)号：US10647708B2
公开(公告)日：2020-05-12
申请号：US15508063
申请日：2015-09-03
申请人： CTXT PTY LTD
IPC分类号： C07D217/04 , C07D413/14 , C07D401/14 , C07D231/12 , C07D295/192 , C07D239/42 , C07D271/10 , C07D401/12 , C07D405/12 , C07D413/12
摘要： A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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6.发明申请公开(公告)号：US20170313713A1
公开(公告)日：2017-11-02
申请号：US15508074
申请日：2015-09-03
申请人： CTXT PTY LTD
发明人： Ylva Elisabet Bergman , Romina Lessene , Danny Ganame , Richard Charles Foitzik , Benjamin Joseph Morrow , Michelle Ang Camerino , Scott Raymond Walker , H. Rachel Lagiakos , John Feutrill , Paul Anthony Stupple
IPC分类号： C07D491/107 , C07C233/78 , C07D451/02 , C07D413/04 , C07D401/12 , C07D401/04 , C07D295/192 , C07D277/68 , C07D277/56 , C07D271/10 , C07D271/08 , C07D265/34 , C07D265/30 , C07D261/18 , C07D235/08 , C07D231/56 , C07D231/20 , C07D231/14 , C07D217/06 , C07D213/82 , C07D213/81 , C07D211/76 , C07D211/58 , C07D211/46 , C07D211/22 , C07D209/44 , C07D207/12 , C07C235/60 , C07C235/42 , C07D451/14 , C07D491/08
CPC分类号： C07D491/107 , C07C233/78 , C07C235/42 , C07C235/50 , C07C235/60 , C07C311/08 , C07C2602/06 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/76 , C07D213/81 , C07D213/82 , C07D217/06 , C07D231/12 , C07D231/14 , C07D231/20 , C07D231/56 , C07D235/08 , C07D261/18 , C07D265/30 , C07D265/34 , C07D271/08 , C07D271/10 , C07D277/56 , C07D277/68 , C07D295/185 , C07D295/192 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/04 , C07D451/02 , C07D451/14 , C07D491/08
摘要： A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R1 and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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公开(公告)号：US20170298075A1
公开(公告)日：2017-10-19
申请号：US15508053
申请日：2015-09-03
申请人： CTXT PTY LTD
发明人： Ylva Elisabet Bergman , Richard Charles Foitzik , Benjamin Joseph Morrow , Michelle Ang Camerino , Scott Raymond Walker , H. Rachel Lagiakos , John Feutrill , Graeme Irvine Stevenson , Paul Anthony Stupple
IPC分类号： C07D491/08 , C07D487/08 , C07D471/04 , C07D417/12 , C07D409/12 , C07D217/16 , C07D405/14 , C07D405/12 , C07D401/14 , C07D401/12 , C07D491/048 , C07D413/12
CPC分类号： C07D491/08 , C07D217/00 , C07D217/16 , C07D231/12 , C07D239/42 , C07D271/10 , C07D295/18 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/08 , C07D491/048
摘要： A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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