- 专利标题: Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors
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申请号: US15508074申请日: 2015-09-03
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公开(公告)号: US10005792B2公开(公告)日: 2018-06-26
- 发明人: Ylva Elisabet Bergman , Romina Lessene , Danny Ganame , Richard Charles Foitzik , Benjamin Joseph Morrow , Michelle Ang Camerino , Scott Raymond Walker , H. Rachel Lagiakos , John Feutrill , Paul Anthony Stupple
- 申请人: CTXT PTY LTD
- 申请人地址: AU Victoria
- 专利权人: CTXT PTY. LTD.
- 当前专利权人: CTXT PTY. LTD.
- 当前专利权人地址: AU Victoria
- 代理机构: Stites & Harbison PLLC
- 代理商 Richard S. Myers, Jr.
- 优先权: GB1415570.9 20140903; GB1508453.6 20150516
- 国际申请: PCT/EP2015/070146 WO 20150903
- 国际公布: WO2016/034671 WO 20160310
- 主分类号: C07D207/12
- IPC分类号: C07D207/12 ; C07D209/44 ; C07D211/22 ; C07D211/46 ; C07D211/58 ; C07D211/76 ; C07D213/81 ; C07D213/82 ; C07D217/06 ; C07D217/12 ; C07D231/14 ; C07D231/20 ; C07D231/56 ; C07D235/08 ; C07D271/08 ; C07D271/10 ; C07D261/18 ; C07D277/56 ; C07D277/68 ; C07D265/30 ; C07D265/34 ; C07D401/04 ; C07D401/12 ; C07D413/04 ; C07D451/02 ; C07D451/14 ; C07D491/08 ; C07D491/107 ; C07C233/78 ; C07C235/42 ; C07C235/60 ; C07D295/192
摘要:
A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
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