公开(公告)号：US12117441B2

公开(公告)日：2024-10-15

申请号：US16668005

申请日：2019-10-30

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Inventor： Francisco Javier Tamayo De Miguel ,  Priscila Monteiro Kosaka ,  Valerio Pini ,  Montserrat Calleja Goméz ,  Jose Jaime Ruz Martinez ,  Daniel Ramos Vega ,  Maria Ujue Gonzalez Sagardoy

IPC: G01N33/53 ,  G01N21/47 ,  G01N21/552 ,  G01N21/59 ,  G01N21/65 ,  G01N21/77 ,  G01N33/543

CPC classification number: G01N33/54346 ,  G01N21/47 ,  G01N21/554 ,  G01N21/59 ,  G01N21/658 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/5903

Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

公开(公告)号：US10281330B2

公开(公告)日：2019-05-07

申请号：US15517809

申请日：2015-10-08

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Inventor： Valerio Pini ,  Priscila Monteiro Kosaka ,  Francisco Javier Tamayo De Miguel ,  Montserrat Calleja Gomez ,  Daniel Ramos Vega ,  Oscar Malvar Vidal ,  Jose Jaime Ruz Martinez ,  Mario Encinar Del Pozo

IPC: G01J3/02 ,  G01J3/28 ,  G01N21/27 ,  G01J3/12 ,  G02B21/00 ,  G01J3/10

Abstract: The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (4), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (5), said processing means having a correlation wherein each of the photodetectors (5) corresponds to a spatial point on the sample (4).In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.