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公开(公告)号：US08110242B2
公开(公告)日：2012-02-07
申请号：US11689754
申请日：2007-03-22
CPC分类号： A61L27/52 , A61L27/28 , A61L27/50 , A61L2420/02 , A61L2430/24 , Y10T428/31536 , Y10T428/31678
摘要： The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.
摘要翻译： 本发明提供水凝胶涂覆的可植入医疗装置和将水凝胶涂覆在可植入医疗装置上的方法。 在一个实施方案中，通过物理处理医疗装置的表面，化学处理表面，施加水凝胶前体，然后使水凝胶前体交联以在医疗装置的表面上形成水凝胶涂层而形成水凝胶涂覆的医疗装置。 本发明可以特别适用于在例如人造关节的可植入医疗装置上涂覆铰接表面。
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公开(公告)号：US20070141108A1
公开(公告)日：2007-06-21
申请号：US11612235
申请日：2006-12-18
申请人： Brian Thomas , Kai Zhang
发明人： Brian Thomas , Kai Zhang
IPC分类号： A61F2/02
CPC分类号： A61L27/48
摘要： This invention provides water-swellable materials including polymeric fibers dispersed in a water-swellable polymer, and fiber-reinforced articles made from such water-swellable materials. The invention also provides a method of forming a fiber-reinforced, water-swellable material. These water-swellable materials and fiber-reinforced articles may be used in biomedical and pharmaceutical applications and may be suitable for implanted joint repair materials such as an articulating or bearing surface in an implanted hip, knee, spine, finger, elbow or shoulder joint.
摘要翻译： 本发明提供包括分散在水溶胀性聚合物中的聚合物纤维的水溶胀性材料和由这种水溶胀性材料制成的纤维增强制品。 本发明还提供一种形成纤维增强的水可溶胀材料的方法。 这些水溶胀性材料和纤维增强制品可以用于生物医学和药物应用中，并且可以适用于植入的关节修复材料，例如植入的髋，膝，脊柱，手指，肘或肩关节中的关节或支承表面。
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公开(公告)号：US20070098799A1
公开(公告)日：2007-05-03
申请号：US11553830
申请日：2006-10-27
申请人： Kai Zhang , Michael Hawkins , Brian Thomas , Hallie Brinkerhuff
发明人： Kai Zhang , Michael Hawkins , Brian Thomas , Hallie Brinkerhuff
摘要： The present invention provides mineralized hydrogels and methods of making and using mineralized hydrogels, by combining a first mixture including a calcium derivative, a second mixture including a phosphate derivative and a hydrogel to form a calcium phosphate dispersion containing the hydrogel. The hydrogel in the calcium phosphate dispersion are crosslinked to form a mineralized hydrogel, in which calcium phosphate minerals are substantially uniformly dispersed within the hydrogel.
摘要翻译： 本发明提供了矿化水凝胶以及使用矿化水凝胶的方法，其中包括钙衍生物，第二混合物，包括磷酸酯衍生物和水凝胶的第一混合物，形成含有该水凝胶的磷酸钙分散体。 将磷酸钙分散体中的水凝胶交联以形成矿化水凝胶，其中磷酸钙矿物基本均匀地分散在水凝胶内。
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公开(公告)号：US08017107B2
公开(公告)日：2011-09-13
申请号：US11614389
申请日：2006-12-21
申请人： Brian Thomas , Kai Zhang
发明人： Brian Thomas , Kai Zhang
IPC分类号： A61K8/72 , A61K31/765 , C08L27/12
CPC分类号： A61L27/52 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2/4241 , A61F2/4261 , A61F2/44 , A61F2002/30075 , A61F2002/30125 , A61F2002/30224 , A61F2210/0061 , A61F2230/0008 , A61F2230/0069 , A61K8/042 , A61K8/8135 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/8176 , A61K8/84 , A61K2800/57 , A61L27/34 , A61Q11/00 , C08L29/04
摘要： This invention provides water-swellable articles and hydrogels that contain a hydrophilic polymer and perfluorocyclobutane crosslinking segments. The perfluorocyclobutane crosslinking segments are covalently attached to the polymeric chains of the hydrophilic polymer so that the crosslinking segments chemically link the polymeric chains to each other. The present invention also provides a method of making a crosslinked hydrogel by first attaching one or more substituted aromatic trifluorovinyl or aromatic trifluorovinyl ether moieties to a hydrophilic polymer to form a modified polymer and then heating the modified polymer at an elevated temperature to form perfluorocyclobutane segments from the trifluorovinyl or trifluorovinyl ether moieties. These water-swellable articles and hydrogels may be used in biomedical and pharmaceutical applications and may be suitable for implanted joint repair materials such as an articulating or bearing surface in a hip, knee, spine, finger, ankle, elbow, wrist, or shoulder joint.
摘要翻译： 本发明提供含有亲水性聚合物和全氟环丁烷交联链段的水溶胀性制品和水凝胶。 全氟环丁烷交联链段共价连接到亲水聚合物的聚合物链上，使得交联链段将聚合物链彼此化学连接。 本发明还提供一种制备交联水凝胶的方法，首先将一个或多个取代的芳族三氟乙烯基或芳族三氟乙烯基醚部分连接到亲水性聚合物上以形成改性聚合物，然后在升高的温度下加热改性聚合物以形成全氟环丁烷链段， 三氟乙烯基或三氟乙烯基醚部分。 这些水溶胀性制品和水凝胶可用于生物医学和药物应用中，并且可适用于植入的关节修复材料，例如髋，膝，脊柱，手指，脚踝，肘，腕或肩关节中的关节或支承表面 。
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公开(公告)号：US20100204800A1
公开(公告)日：2010-08-12
申请号：US12767016
申请日：2010-04-26
申请人： Brian Thomas , Kai Zhang
发明人： Brian Thomas , Kai Zhang
IPC分类号： A61F2/28 , C08L39/00 , C08L29/04 , C08L33/08 , C08L75/04 , C08L83/00 , C08L33/20 , C08L33/26 , C08L33/02 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/44 , A61F2/42
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.
摘要翻译： 本发明提供了具有第一聚合物，水可溶胀材料和第二聚合物材料的多聚物水凝胶制品，其被组织成使得第一区域基本上包含第一聚合物，水可溶胀材料，与第一区域相邻的第二区域包括 第一聚合物，水可溶胀材料和第二聚合物材料的混合物以及与第二区域相邻的第三区域基本上包括第二聚合物材料。 该制品表现出第二聚合物材料从第一区域通过第二区域移动到第三区域的浓度梯度增加。 本发明还提供了通过（a）使用第一聚合物，水可溶胀材料形成水凝胶结构来形成多聚物水凝胶制品的方法，（b）通过使水凝胶结构脱水来产生具有多个开孔的气凝胶结构， （c）使所述气凝胶结构与第二聚合物材料接触，以将所述第二聚合物材料结合到所述多个开孔中的至少一部分中以形成所述多聚物水凝胶制品，和（d）使所述多聚物水凝胶制品再水化。
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公开(公告)号：US20070225823A1
公开(公告)日：2007-09-27
申请号：US11689754
申请日：2007-03-22
申请人： Michael Hawkins , Dirk Pletcher , Brian Thomas , Kai Zhang , Hallie Brinkerhuff
发明人： Michael Hawkins , Dirk Pletcher , Brian Thomas , Kai Zhang , Hallie Brinkerhuff
CPC分类号： A61L27/52 , A61L27/28 , A61L27/50 , A61L2420/02 , A61L2430/24 , Y10T428/31536 , Y10T428/31678
摘要： The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.
摘要翻译： 本发明提供水凝胶涂覆的可植入医疗装置和将水凝胶涂覆在可植入医疗装置上的方法。 在一个实施方案中，通过物理处理医疗装置的表面，化学处理表面，施加水凝胶前体，然后使水凝胶前体交联以在医疗装置的表面上形成水凝胶涂层而形成水凝胶涂覆的医疗装置。 本发明可以特别适用于在例如人造关节的可植入医疗装置上涂覆铰接表面。
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公开(公告)号：US20070134333A1
公开(公告)日：2007-06-14
申请号：US11608128
申请日：2006-12-07
申请人： Brian Thomas , Kai Zhang , Garryl Hudgins , Robert Hodorek
发明人： Brian Thomas , Kai Zhang , Garryl Hudgins , Robert Hodorek
IPC分类号： A61K47/30
CPC分类号： A61L24/06 , A61L24/0031 , A61L27/16 , A61L27/52 , C08L29/04
摘要： This invention provides methods and processes to attach or bond hydrogels to suitable surfaces using irradiation techniques and also provides methods and processes to create crosslinked regions in hydrogel articles using these irradiation techniques. Specifically, lasers at wavelengths tuned to the irradiation absorption bands of hydroxyl groups, carboxylic acid groups or water may be used to attach or bond hydrogels to surfaces such as soft tissue and hydrogel surfaces or to crosslink regions in hydrogel articles.
摘要翻译： 本发明提供了使用照射技术将水凝胶附着或粘合到合适表面上的方法和方法，并且还提供使用这些照射技术在水凝胶制品中产生交联区域的方法和方法。 具体地，可以使用调谐到羟基，羧酸基团或水的照射吸收带的波长的激光器将水凝胶附着或粘合到表面，例如软组织和水凝胶表面，或者在水凝胶制品中交联区域。
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公开(公告)号：US08262730B2
公开(公告)日：2012-09-11
申请号：US11608128
申请日：2006-12-07
申请人： Brian Thomas , Kai Zhang , Garryl Hudgins , Robert Hodorek
发明人： Brian Thomas , Kai Zhang , Garryl Hudgins , Robert Hodorek
CPC分类号： A61L24/06 , A61L24/0031 , A61L27/16 , A61L27/52 , C08L29/04
摘要： This invention provides methods and processes to attach or bond hydrogels to suitable surfaces using irradiation techniques and also provides methods and processes to create crosslinked regions in hydrogel articles using these irradiation techniques. Specifically, lasers at wavelengths tuned to the irradiation absorption bands of hydroxyl groups, carboxylic acid groups or water may be used to attach or bond hydrogels to surfaces such as soft tissue and hydrogel surfaces or to crosslink regions in hydrogel articles.
摘要翻译： 本发明提供了使用照射技术将水凝胶附着或粘合到合适表面上的方法和方法，并且还提供使用这些照射技术在水凝胶制品中产生交联区域的方法和方法。 具体地，可以使用调谐到羟基，羧酸基团或水的照射吸收带的波长的激光器将水凝胶附着或粘合到表面，例如软组织和水凝胶表面，或者在水凝胶制品中交联区域。
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公开(公告)号：US20090035344A1
公开(公告)日：2009-02-05
申请号：US11833549
申请日：2007-08-03
申请人： Brian Thomas , Kai Zhang
发明人： Brian Thomas , Kai Zhang
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.
摘要翻译： 本发明提供了具有第一聚合物，水可溶胀材料和第二聚合物材料的多聚物水凝胶制品，其被组织成使得第一区域基本上包含第一聚合物，水可溶胀材料，与第一区域相邻的第二区域包括 第一聚合物，水可溶胀材料和第二聚合物材料的混合物以及与第二区域相邻的第三区域基本上包括第二聚合物材料。 该制品表现出第二聚合物材料从第一区域通过第二区域移动到第三区域的浓度梯度增加。 本发明还提供了通过（a）使用第一聚合物，水可溶胀材料形成水凝胶结构来形成多聚物水凝胶制品的方法，（b）通过使水凝胶结构脱水来产生具有多个开孔的气凝胶结构， （c）使所述气凝胶结构与第二聚合物材料接触，以将所述第二聚合物材料结合到所述多个开孔中的至少一部分中以形成所述多聚物水凝胶制品，和（d）使所述多聚物水凝胶制品再水化。
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公开(公告)号：US08236342B2
公开(公告)日：2012-08-07
申请号：US12767016
申请日：2010-04-26
申请人： Brian Thomas , Kai Zhang
发明人： Brian Thomas , Kai Zhang
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.
摘要翻译： 本发明提供了具有第一聚合物，水可溶胀材料和第二聚合物材料的多聚物水凝胶制品，其被组织成使得第一区域基本上包含第一聚合物，水可溶胀材料，与第一区域相邻的第二区域包括 第一聚合物，水可溶胀材料和第二聚合物材料的混合物以及与第二区域相邻的第三区域基本上包括第二聚合物材料。 该制品表现出第二聚合物材料从第一区域通过第二区域移动到第三区域的浓度梯度增加。 本发明还提供了通过（a）使用第一聚合物，水可溶胀材料形成水凝胶结构来形成多聚物水凝胶制品的方法，（b）通过使水凝胶结构脱水来产生具有多个开孔的气凝胶结构， （c）使所述气凝胶结构与第二聚合物材料接触，以将所述第二聚合物材料结合到所述多个开孔中的至少一部分中以形成所述多聚物水凝胶制品，和（d）使所述多聚物水凝胶制品再水化。
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