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公开(公告)号：US11717567B2
公开(公告)日：2023-08-08
申请号：US17194779
申请日：2021-03-08
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： SangKon Oh , Sandra Zurawski , Gerard Zurawski
IPC: A61K39/12 , A61K39/395 , C07K14/025 , C07K16/28 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: A61K39/12 , A61K39/395 , A61K39/3955 , A61K39/39541 , C07K14/005 , C07K16/2878 , C12N7/00 , A61K2039/505 , A61K2039/53 , A61K2039/55511 , A61K2039/585 , A61K2039/6056 , A61K2039/70 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2319/74 , C07K2319/91 , C12N2710/20034
Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.
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公开(公告)号：US20170106051A1
公开(公告)日：2017-04-20
申请号：US15311572
申请日：2015-05-15
Applicant: Baylor Research Institute
Inventor： SangKon Oh , Sandra Zurawski , Hyemee Joo , Gerard Zurawski
CPC classification number: A61K38/2066 , A61K39/0008 , A61K2039/505 , A61K2039/54 , A61K2039/57 , C07K14/5428 , C07K16/2851 , C07K16/2878 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2319/00
Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
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公开(公告)号：US09567401B2
公开(公告)日：2017-02-14
申请号：US14165400
申请日：2014-01-27
Applicant: Baylor Research Institute
Inventor： Jacques F. Banchereau , Gerard Zurawski , Sandra Zurawski , SangKon Oh
IPC: A61K39/395 , C07K16/28 , C07K14/005 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/00 , A61K2039/6056 , C07K14/005 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/74 , C07K2317/80 , C07K2319/00 , C12N2740/16222 , C12N2740/16322
Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。
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公开(公告)号：US09339556B2
公开(公告)日：2016-05-17
申请号：US13927437
申请日：2013-06-26
Applicant: Baylor Research Institute
Inventor： Jacques F. Banchereau , SangKon Oh , Gerard Zurawski , Sandra Zurawski , Dapeng Li
CPC classification number: A61K47/48369 , A61K2039/5154 , A61K2039/55516 , C07K16/28 , C07K2317/92 , C07K2319/01 , C07K2319/33
Abstract: The present invention includes compositions and methods for targeting the LOX-1 receptor on immune cells and uses for the anti-LOX-1 antibodies.
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公开(公告)号：US10993990B2
公开(公告)日：2021-05-04
申请号：US15311572
申请日：2015-05-15
Applicant: Baylor Research Institute
Inventor： SangKon Oh , Sandra Zurawski , Hyemee Joo , Gerard Zurawski
Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
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Patent Agency Ranking
公开(公告)号：US10980869B2
公开(公告)日：2021-04-20
申请号：US15703685
申请日：2017-09-13
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Peter Klucar , Keiko Akagawa , Sandra Zurawski , SangKon Oh
IPC: A61K39/00 , A61K39/395 , C07K16/28 , C07K14/435
Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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公开(公告)号：US20160022792A1
公开(公告)日：2016-01-28
申请号：US14819909
申请日：2015-08-06
Applicant: Baylor Research Institute
Inventor： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Peter Klucar , Keiko Akagawa , Sandra Zurawski , SangKon Oh
IPC: A61K39/00 , C07K14/435 , C07K16/28
CPC classification number: A61K39/0011 , A61K2039/6056 , C07K14/435 , C07K16/2878 , C07K2319/00 , C07K2319/33 , C07K2319/91 , Y02A50/39 , Y02A50/466
Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。
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公开(公告)号：US20250018025A1
公开(公告)日：2025-01-16
申请号：US18670211
申请日：2024-05-21
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： SangKon OH , Dapeng LI , Jacques Banchereau , Gerard Zurawski , Sandra Zurawski
IPC: A61K39/145 , A61K39/00 , A61K47/68 , A61K51/10 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/435 , C07K16/28 , C12N5/0784 , C12N7/00
Abstract: The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
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公开(公告)号：US11957734B2
公开(公告)日：2024-04-16
申请号：US17301123
申请日：2021-03-25
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： SangKon Oh , Sandra Zurawski , Hyemee Joo , Gerard Zurawski
CPC classification number: A61K38/2066 , A61K39/0008 , C07K14/5428 , C07K16/2851 , C07K16/2878 , A61K2039/505 , A61K2039/54 , A61K2039/57 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2319/00
Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
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公开(公告)号：US20220340670A1
公开(公告)日：2022-10-27
申请号：US17687971
申请日：2022-03-07
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： Jacques F. Banchereau , Gerard Zurawski , Sandra Zurawski , SangKon Oh
IPC: C07K16/28 , C07K14/005
Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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