公开(公告)号：US10993990B2

公开(公告)日：2021-05-04

申请号：US15311572

申请日：2015-05-15

Applicant: Baylor Research Institute

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  C07K14/54 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US20170106051A1

公开(公告)日：2017-04-20

申请号：US15311572

申请日：2015-05-15

Applicant: Baylor Research Institute

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  C07K16/28 ,  A61K39/00 ,  C07K14/54

CPC classification number: A61K38/2066 ,  A61K39/0008 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/57 ,  C07K14/5428 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2319/00

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US10570208B2

公开(公告)日：2020-02-25

申请号：US16210188

申请日：2018-12-05

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Yong-Jun Liu ,  Sandra Zurawski ,  SangKon Oh ,  Shino Hanabuchi ,  Haruyuki Fujita ,  Hideki Ueno ,  Patrick Blanco ,  Hyemee Joo

IPC: C07H21/04 ,  C12P21/06 ,  C12N5/00 ,  C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  A61K39/00

Abstract: Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell—(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.

公开(公告)号：US20190092869A1

公开(公告)日：2019-03-28

申请号：US16210188

申请日：2018-12-05

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Yong-Jun Liu ,  Sandra Zurawski ,  SangKon Oh ,  Shino Hanabuchi ,  Haruyuki Fujita ,  Hideki Ueno ,  Patrick Blanco ,  Hyemee Joo

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2875 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell—(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.

公开(公告)号：US11957734B2

公开(公告)日：2024-04-16

申请号：US17301123

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  A61K39/00 ,  C07K14/54 ,  C07K16/28

CPC classification number: A61K38/2066 ,  A61K39/0008 ,  C07K14/5428 ,  C07K16/2851 ,  C07K16/2878 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/57 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2319/00

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US10167339B2

公开(公告)日：2019-01-01

申请号：US15501526

申请日：2015-08-03

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Yong-Jun Liu ,  Sandra Zurawski ,  SangKon Oh ,  Shino Hanabuchi ,  Haruyuki Fujita ,  Hideki Ueno ,  Patrick Blanco ,  Hyemee Joo

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell—(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.