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公开(公告)号：US10557163B2
公开(公告)日：2020-02-11
申请号：US15881246
申请日：2018-01-26
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Ming-Hsiung Yeh
Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.
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Patent Agency Ranking
公开(公告)号：US20180148760A1
公开(公告)日：2018-05-31
申请号：US15881246
申请日：2018-01-26
Applicant: Becton Dickinson and Company
Inventor： Ming-Hsiung Yeh
CPC classification number: C12Q1/04 , B01L3/50853 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/069 , B01L2400/0694 , C12M41/36 , G01N33/50 , G01N2800/26
Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.
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公开(公告)号：US09909162B2
公开(公告)日：2018-03-06
申请号：US14775100
申请日：2013-03-11
Applicant: Becton, Dickinson and Company
Inventor： Ming-Hsiung Yeh
CPC classification number: C12Q1/04 , B01L3/50853 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/069 , B01L2400/0694 , C12M41/36 , G01N33/50 , G01N2800/26
Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.
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公开(公告)号：US11090228B2
公开(公告)日：2021-08-17
申请号：US16325617
申请日：2017-08-18
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Ammon David Lentz , Brent D. Ludwig , Adam Steel , Ming-Hsiung Yeh
Abstract: Various embodiments of the present disclosure describe systems and methods for testing samples (e.g., biological samples, environmental samples, food samples etc.) for microbial contamination. For example, some embodiments describe an adapter assembly with a means to penetrate a septum of a collection vessel and permit gaseous communication between a headspace of the collection vessel and a sensor. In some embodiments, the gases in the headspace of the collection vessel can exit the collection vessel without contaminating the environment outside the system or allowing sample contamination. In some embodiments, the adapter assembly includes a membrane configured to prevent liquid in the collection vessel from contacting the sensor. In some embodiments, the adapter assembly can be used to access media inside the collection vessel for subculturing or aliquotting for another diagnostic process such as molecular diagnostics.
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公开(公告)号：US20190183730A1
公开(公告)日：2019-06-20
申请号：US16325617
申请日：2017-08-18
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Ammon David Lentz , Brent D. Ludwig , Adam Steel , Ming-Hsiung Yeh
CPC classification number: A61J1/2096 , A61J7/00 , A61M5/32 , B65D51/00 , G01N1/2226 , G01N33/4925 , G01N2001/2229 , G01N2001/2241 , G01N2033/4977
Abstract: Various embodiments of the present disclosure describe systems and methods for testing samples (e.g., biological samples, environmental samples, food samples etc.) for microbial contamination. For example, some embodiments describe an adapter assembly with a means to penetrate a septum of a collection vessel and permit gaseous communication between a headspace of the collection vessel and a sensor. In some embodiments, the gases in the headspace of the collection vessel can exit the collection vessel without contaminating the environment outside the system or allowing sample contamination. In some embodiments, the adapter assembly includes a membrane configured to prevent liquid in the collection vessel from contacting the sensor. In some embodiments, the adapter assembly can be used to access media inside the collection vessel for subculturing or aliquotting for another diagnostic process such as molecular diagnostics.
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公开(公告)号：US20160024549A1
公开(公告)日：2016-01-28
申请号：US14775100
申请日：2013-03-11
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Ming-Hsiung Yeh
CPC classification number: C12Q1/04 , B01L3/50853 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/069 , B01L2400/0694 , C12M41/36 , G01N33/50 , G01N2800/26
Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.
Abstract translation: 本文描述了用于快速检测生物样品（例如血液）中的微生物用于分析以确定样品中感染性微生物的存在或不存在的方法和装置。 该装置包括具有盖和托盘的盒，用于将散装样品分离成多个较小样品的机构，以及设置在托盘上以确定微生物存在或不存在的传感器。 墨盒盖包括突起，其在第一位置允许样品均匀地分布在墨盒托盘中，并且在第二位置将样品隔离成多个较小体积的样品。 该装置和方法缩短了样品中微生物的检测时间，并减少了从样品收集到微生物检测所需的步骤。
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