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公开(公告)号：US20230208045A1
公开(公告)日：2023-06-29
申请号：US18111765
申请日：2023-02-20
Applicant: Battelle Memorial Institute
Inventor： Eric Scribben , Steven M. Heintz , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
CPC classification number: H01Q21/062 , H01Q1/48 , H01Q21/245 , H01Q1/243
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US09737662B2
公开(公告)日：2017-08-22
申请号：US14356859
申请日：2012-11-07
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Eric C. Scribben , John D. Clay , Jeffrey L. Ellis , Amy M. Heintz , Steven M. Risser , Timothy M. Blum
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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3.发明公开公开(公告)号：US20230277109A1
公开(公告)日：2023-09-07
申请号：US18017899
申请日：2021-07-30
Applicant: Battelle Memorial Institute
Inventor： Timothy M. Blum , Joshua R. Branch , Samuel Colachis , Amanda I. Noonan , John E. Bartholomew , Nicholas Annetta , Yelena Davis
CPC classification number: A61B5/256 , A61B5/296 , A61B5/397 , A61B5/4836 , A61B5/6824 , A61B5/301 , A61B5/313 , A61N1/0452 , A61N1/0476 , A61N1/0484 , A61N1/36003 , A61N1/36031 , A61B5/725 , A61B2562/0209 , A61B2562/046 , A61B2562/182
Abstract: A device for functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), and/or in receiving electromyography (EMG) signals includes a sleeve and electrodes. The sleeve is sized and shaped to be worn on a human arm, and comprises a stretchable fabric The electrodes are secured with the sleeve and positioned to contact skin of the human arm when the sleeve is worn on the human arm. An electronic circuit is configured to operate the electrodes. The electronic circuit includes relays connecting the electrodes with a stimulator for performing FES or NMES, and EMG readout circuitry connecting the electrodes with an EMG amplifier. The relays are closed during FES or NMES to connect the stimulator with the electrodes. The relays are open during EMG readout to isolate the stimulator from the EMG amplifier.
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4.发明公开公开(公告)号：US20230191115A1
公开(公告)日：2023-06-22
申请号：US18017770
申请日：2021-07-14
Applicant: Battelle Memorial Institute
Inventor： Timothy M. Blum , Joshua R. Branch , Samuel Colachis , Amanda I. Noonan , John E. Bartholomew , Nicholas Annetta , Yelena Davis
IPC: A61N1/04
CPC classification number: A61N1/0484 , A61N1/0476 , A61N1/0456 , A61N1/0452
Abstract: A device for functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), and/or in receiving electromyography (EMG) signals includes a sleeve and electrodes. The sleeve is sized and shaped to be worn on a human arm, and comprises a stretchable fabric The sleeve has a distal end disposed on or adjacent a wrist of the human arm when the sleeve is worn on the human arm and a proximal end opposite from the distal end. The electrodes are secured with the sleeve and positioned to contact skin of the human arm when the sleeve is worn on the human arm. The sleeve may include an inner sleeve contact with the skin and an outer sleeve disposed over the inner sleeve. The inner sleeve has openings in which the electrodes are disposed.
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公开(公告)号：US11590285B2
公开(公告)日：2023-02-28
申请号：US16659592
申请日：2019-10-22
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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Patent Agency Ranking
公开(公告)号：US20140324022A1
公开(公告)日：2014-10-30
申请号：US14356859
申请日：2012-11-07
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
IPC: A61M5/20
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
Abstract translation: 核心环形流动用于使皮下递送粘性流体，例如蛋白质治疗剂型。 高粘度流体被低粘度流体包围，低粘度流体润滑高粘度流体的通道。 这允许使用在相对减少的注射力下降低注射时间的具有较高浓度和较高粘度的蛋白质制剂。 这里描述了提供芯环形流的注射装置的几个不同实施例。
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公开(公告)号：US20240091449A1
公开(公告)日：2024-03-21
申请号：US18473857
申请日：2023-09-25
Applicant: Battelle Memorial Institute
Inventor： William G. Atterbury , Timothy M. Blum , David A. Holley , John P. Tallarico , Steven M. Madland
CPC classification number: A61M5/2033 , A61M5/31586 , A61M5/3234 , A61M2005/2013 , A61M2005/202 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2005/2086
Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.
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公开(公告)号：US11801346B2
公开(公告)日：2023-10-31
申请号：US16845065
申请日：2020-04-09
Applicant: Battelle Memorial Institute
Inventor： William G. Atterbury , Timothy M. Blum , David A. Holley , John P. Tallarico , Steven M. Madland
CPC classification number: A61M5/2033 , A61M5/31586 , A61M5/3234 , A61M2005/202 , A61M2005/206 , A61M2005/208 , A61M2005/2013 , A61M2005/2073 , A61M2005/2086
Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.
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公开(公告)号：US20200054831A1
公开(公告)日：2020-02-20
申请号：US16659592
申请日：2019-10-22
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US20170312434A1
公开(公告)日：2017-11-02
申请号：US15652214
申请日：2017-07-17
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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