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公开(公告)号：US20200054831A1
公开(公告)日：2020-02-20
申请号：US16659592
申请日：2019-10-22
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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2.发明申请PBO Fibers with Improved Mechanical Properties when Exposed to High Temperatures and High Relative Humidity 有权PBO纤维在暴露于高温和高相对湿度时具有改进的机械性能公开(公告)号：US20150067940A1
公开(公告)日：2015-03-12
申请号：US14391984
申请日：2013-04-11
Applicant: Battelle Memorial Institute
Inventor： Jay R Sayre , Vince McGinniss , C Byron Tolbert , Kelly J Jenkins , Jeffrey L. Ellis , Tim B Hutson , Sundee Angel , Rachel Thurston
IPC: D06M13/513 , C08K5/5435 , B29C35/02 , F41H1/02
CPC classification number: D06M13/513 , B29C35/0227 , B29K2083/00 , B29L2031/731 , C08K5/5435 , D06M23/105 , F41H1/02 , Y02P20/544
Abstract: A method of treating fibers to improve resistance to high temperatures and relative humidity includes providing poly(p-phenylene-2,6-benzobisoxazole) (PBO) fibers, exposing the PBO fibers to an atmosphere of supercritical CO2 saturated with an epoxy silane, i.e. 3-glycidoxypropyl methyldimethoxysilane. The PBO fibers are subjected to a first pressurizing and heating stage at a first temperature (50° C.) for a first period of time. The PBO fibers are then subjected to a second pressurizing and heating stage including increasing the temperature to a second temperature (110° C.) and holding at the second temperature for an additional period of time. The PBO fibers include 2-5 wt % of 3-glycidoxypropyl methyldimethoxysilane after diffusing the CO2 out of the PBO fibers. The fibers are particularly useful in making lightweight body armor system components.
Abstract translation: 处理纤维以改善耐高温和相对湿度的方法包括提供聚（对亚苯基-2,6-苯并双恶唑）（PBO）纤维，将PBO纤维暴露于用环氧硅烷饱和的超临界CO 2气氛中，即 3-环氧丙氧基丙基甲基二甲氧基硅烷。 PBO纤维在第一温度（50℃）下经受第一加压和加热阶段第一段时间。 然后将PBO纤维进行第二加压和加热阶段，包括将温度升高至第二温度（110℃），并在第二温度下保持另外的时间。 PBO纤维在将CO 2从PBO纤维中扩散出来之后，包括2-5重量％的3-缩水甘油氧基丙基甲基二甲氧基硅烷。 纤维在制造轻量级的装甲系统部件中特别有用。
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公开(公告)号：US20230208045A1
公开(公告)日：2023-06-29
申请号：US18111765
申请日：2023-02-20
Applicant: Battelle Memorial Institute
Inventor： Eric Scribben , Steven M. Heintz , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
CPC classification number: H01Q21/062 , H01Q1/48 , H01Q21/245 , H01Q1/243
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US09737662B2
公开(公告)日：2017-08-22
申请号：US14356859
申请日：2012-11-07
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Eric C. Scribben , John D. Clay , Jeffrey L. Ellis , Amy M. Heintz , Steven M. Risser , Timothy M. Blum
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US20210112627A1
公开(公告)日：2021-04-15
申请号：US17030329
申请日：2020-09-23
Applicant: Battelle Memorial Institute
Inventor： Katherine M. Palmer , Kurt Bosworth , Kevin Yugulis , Amy M. Heintz , Jeffrey L. Ellis
Abstract: A device is described in which the shape of a resistive heater material is configured to provide rapid and strong heating of a small area. The resistive heating material is heated unevenly while efficiently using power.
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Patent Agency Ranking
公开(公告)号：US20170312434A1
公开(公告)日：2017-11-02
申请号：US15652214
申请日：2017-07-17
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US20240292496A1
公开(公告)日：2024-08-29
申请号：US18582530
申请日：2024-02-20
Applicant: Battelle Memorial Institute
Inventor： Katherine M. Palmer , Kurt Bosworth , Kevin Yugulis , Amy M. Heintz , Jeffrey L. Ellis
CPC classification number: H05B3/0004 , H05B3/03 , H05B3/10 , H05B3/34 , H05B2203/007 , H05B2203/013 , H05B2203/016 , H05B2203/037
Abstract: A device is described in which the shape of a resistive heater material is configured to provide rapid and strong heating of a small area. The resistive heating material is heated unevenly while efficiently using power.
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公开(公告)号：US11937342B2
公开(公告)日：2024-03-19
申请号：US17030329
申请日：2020-09-23
Applicant: Battelle Memorial Institute
Inventor： Katherine M. Palmer , Kurt Bosworth , Kevin Yugulis , Amy M. Heintz , Jeffrey L. Ellis
CPC classification number: H05B3/0004 , H05B3/03 , H05B3/10 , H05B3/34 , H05B2203/007 , H05B2203/013 , H05B2203/016 , H05B2203/037
Abstract: A device is described in which the shape of a resistive heater material is configured to provide rapid and strong heating of a small area. The resistive heating material is heated unevenly while efficiently using power.
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公开(公告)号：US11590285B2
公开(公告)日：2023-02-28
申请号：US16659592
申请日：2019-10-22
Applicant: Battelle Memorial Institute
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
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公开(公告)号：US20220339351A1
公开(公告)日：2022-10-27
申请号：US17761570
申请日：2020-09-23
Applicant: Battelle Memorial Institute
Inventor： Jeffrey L. Ellis , John P. Tallarico , Jeffrey J. Boyce
Abstract: Processes and devices for delivering a fluid by decomposition of hydrogen peroxide are disclosed. Advantageously, the reaction is very fast and exothermic resulting in a fast ejection and, optionally, heating a fluid as it is ejected from a container. Also disclosed is a fluid flow system powered by a gas-generating reaction that is activated by an electrothermal activation switch.
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