知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.023 seconds)

    MICROORGANISM FOR EXPRESSING A HUMAN MEMBRANE PROTEIN
    2.
    发明申请
    MICROORGANISM FOR EXPRESSING A HUMAN MEMBRANE PROTEIN 审中-公开
    用于表达人膜蛋白的MICROORGANISM

    公开(公告)号：US20120156695A1

    公开(公告)日：2012-06-21

    申请号：US13321371

    申请日：2010-04-01

    Applicant: Michael Schilling ,  Christine Lang ,  Andreas Raab

    Inventor： Michael Schilling ,  Christine Lang ,  Andreas Raab

    IPC: C12P33/00 ,  C12N1/13 ,  G01N33/53 ,  C12N1/15 ,  C12N5/10 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19

    CPC classification number: C12P33/00 ,  C07K14/705 ,  C12N15/81 ,  C12P21/02

    Abstract: The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The invention further relates to different uses of such an organism, to a test kit comprising such an organism, and to a membrane extract of such an organism.

    Abstract translation: 本发明涉及与野生型相比具有增加的HMG-CoA还原酶活性的分离的转基因生物非哺乳动物生物体，与野生型相比具有降低的C24-甲基转移酶和/或δ22-去饱和酶活性。 本发明的特征在于与野生型相比，生物体具有增加的脱氢胆固醇-δ70-还原酶活性。 本发明还涉及这种生物体的不同用途，包含这种生物体的测试试剂盒以及这种生物体的膜提取物。

    Microorganism for the production of succinic acid
    3.
    发明授权
    Microorganism for the production of succinic acid 有权
    微生物用于生产琥珀酸

    公开(公告)号：US08685704B2

    公开(公告)日：2014-04-01

    申请号：US12596771

    申请日：2008-04-16

    Applicant: Christine Lang ,  Markus Veen ,  Mewes Bottner ,  Andreas Raab

    Inventor： Christine Lang ,  Markus Veen ,  Mewes Bottner ,  Andreas Raab

    IPC: C12N1/00

    CPC classification number: C12P7/46 ,  C12N1/18 ,  C12N9/0006 ,  C12N9/88

    Abstract: The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising “PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3” are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.

    Abstract translation: 本发明涉及分离的遗传修饰的微生物，其中基因IDH1和至少一个基因SDH2和DIC1处于被培养添加剂压制至生长培养基的第一启动子的控制之下，并且活性物质 缺乏培养添加剂。 作为包含“PYC1，ACS1，CIT1，ACO1，ICL1，MSL1和CIT2，任选还有MDH 3”的组的一部分的基因是组成型活性的。 本发明还涉及这种微生物，特别是用于生产琥珀酸的用途。

    YEAST CELL FOR THE PRODUCTION OF TERPENES AND USES THEREOF
    6.
    发明申请
    YEAST CELL FOR THE PRODUCTION OF TERPENES AND USES THEREOF 有权
    YEAST细胞生产牛皮癣及其用途

    公开(公告)号：US20140057328A1

    公开(公告)日：2014-02-27

    申请号：US13984761

    申请日：2012-02-15

    Applicant: Andreas Raab ,  Christine Lang

    Inventor： Andreas Raab ,  Christine Lang

    IPC: C12P5/02 ,  C12N15/81

    CPC classification number: C12P5/026 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/1025 ,  C12N15/81 ,  C12P5/02

    Abstract: The present invention relates to a yeast cell, wherein said cell comprises a functional gene coding for soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene(s) coding for steryl acyltransferase(s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Moreover, the present invention relates to the use of said cell for the production of one or more terpene(s). Further, the present invention relates to methods of generating said cell and the production of one or more terperne(s) and a pharmaceutical or cosmetically composition, a lubricant or transformer oil comprising said terpene(s).

    Abstract translation: 本发明涉及酵母细胞，其中所述细胞包含编码可溶性羟甲基戊二酰辅酶A（HMG-CoA）还原酶的功能基因; 编码所述细胞中的甾体酰基转移酶的一个或多个基因有缺陷或缺失; 并且所述细胞至少是组氨酸，亮氨酸或尿嘧啶的营养型。 此外，本发明涉及所述电池用于生产一种或多种萜烯的用途。 此外，本发明涉及生成所述细胞的方法以及生产一种或多种三元醇和药物或美容组合物，包含所述萜烯的润滑剂或变压器油。

    MICROORGANISM FOR PRODUCING SUCCINIC ACID
    7.
    发明申请
    MICROORGANISM FOR PRODUCING SUCCINIC ACID 审中-公开
    生产酸中毒的微生物

    公开(公告)号：US20110300595A1

    公开(公告)日：2011-12-08

    申请号：US13124436

    申请日：2009-10-07

    Applicant: Christine Lang ,  Andreas Raab

    Inventor： Christine Lang ,  Andreas Raab

    IPC: C12P7/46 ,  C12N1/19

    CPC classification number: C12P7/46 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1025 ,  C12N9/88 ,  C12N9/93 ,  C12Y101/01037 ,  C12Y101/01042 ,  C12Y103/05001 ,  C12Y203/03009 ,  C12Y401/03001 ,  C12Y602/01001

    Abstract: The invention relates to an isolated, genetically modified microorganism, wherein compared to the wild type a) the idh1 and idp1 genes have been deleted or inactivated, and/or b) the sdh2 and sdh1 genes have been deleted or inactivated, and/or c) the PDC2 gene has been deleted or inactivated or is under the control of a promoter which can be suppressed or induced by exposure of the microorganism using an inductor substance, and/or d) one or more genes from the group consisting of ICL1, MLS1, ACS1 and MDH3 has been replaced or supplemented by a corresponding foreign gene or corresponding foreign genes from Crabtree-negative organisms, and to the uses thereof.

    Abstract translation: 本发明涉及一种分离的遗传修饰的微生物，其中与野生型相比a）idh1和idp1基因已被缺失或失活，和/或b）sdh2和sdh1基因已被缺失或失活，和/或c ）PDC2基因已经被缺失或失活，或处于通过使用电感物质暴露微生物可以抑制或诱导的启动子的控制下，和/或d）来自ICL1，MLS1的一个或多个基因 ACS1和MDH3已经被相应的外来基因或来自Crabtree阴性生物体的相应的外来基因所替代或补充，以及其用途。

    MICROORGANISM FOR THE PRODUCTION OF SUCCINIC ACID
    8.
    发明申请
    MICROORGANISM FOR THE PRODUCTION OF SUCCINIC ACID 有权
    生产酸性农药的微生物

    公开(公告)号：US20110129885A1

    公开(公告)日：2011-06-02

    申请号：US12596771

    申请日：2008-04-16

    Applicant: Christine Lang ,  Markus Veen ,  Mewes Böttner ,  Andreas Raab

    Inventor： Christine Lang ,  Markus Veen ,  Mewes Böttner ,  Andreas Raab

    IPC: C12P7/40 ,  C12N1/00 ,  C12N1/19 ,  C12P7/46 ,  C12N15/81 ,  C12P7/50 ,  C12P7/56 ,  C12P7/54

    CPC classification number: C12P7/46 ,  C12N1/18 ,  C12N9/0006 ,  C12N9/88

    Abstract: The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising “PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3” are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.

    Abstract translation: 本发明涉及分离的遗传修饰的微生物，其中基因IDH1和至少一个基因SDH2和DIC1处于被培养添加剂压制至生长培养基的第一启动子的控制之下，并且活性物质 缺乏培养添加剂。 作为包含“PYC1，ACS1，CIT1，ACO1，ICL1，MSL1和CIT2，任选还有MDH 3”的组的一部分的基因是组成型活性的。 本发明还涉及这种微生物，特别是用于生产琥珀酸的用途。

    Yeast cell for the production of terpenes and uses thereof
    10.
    发明授权
    Yeast cell for the production of terpenes and uses thereof 有权
    用于生产萜烯的酵母细胞及其用途

    公开(公告)号：US09051587B2

    公开(公告)日：2015-06-09

    申请号：US13984761

    申请日：2012-02-15

    Applicant: Andreas Raab ,  Christine Lang

    Inventor： Andreas Raab ,  Christine Lang

    IPC: C12P5/02 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N15/81

    CPC classification number: C12P5/026 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/1025 ,  C12N15/81 ,  C12P5/02

    Abstract: The present invention relates to a yeast cell, wherein said cell comprises a functional gene coding for soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene(s) coding for steryl acyltransferase(s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Moreover, the present invention relates to the use of said cell for the production of one or more terpene(s). Further, the present invention relates to methods of generating said cell and the production of one or more terperne(s) and a pharmaceutical or cosmetically composition, a lubricant or transformer oil comprising said terpene(s).

    Abstract translation: 本发明涉及酵母细胞，其中所述细胞包含编码可溶性羟甲基戊二酰辅酶A（HMG-CoA）还原酶的功能基因; 编码所述细胞中的甾体酰基转移酶的一个或多个基因有缺陷或缺失; 并且所述细胞至少是组氨酸，亮氨酸或尿嘧啶的营养型。 此外，本发明涉及所述电池用于生产一种或多种萜烯的用途。 此外，本发明涉及生成所述细胞的方法以及生产一种或多种三元醇和药物或化妆品组合物，包含所述萜烯的润滑剂或变压器油。

Patent Agency Ranking