公开(公告)号：US5791344A

公开(公告)日：1998-08-11

申请号：US582756

申请日：1996-01-04

申请人： Joseph H. Schulman ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann ,  Orville Rey Rule, III ,  David I. Whitmoyer

发明人： Joseph H. Schulman ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann ,  Orville Rey Rule, III ,  David I. Whitmoyer

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/14865 ,  A61B5/6849 ,  A61B2562/08 ,  A61B5/742

摘要： A patient monitoring system measures the concentration of a particular substance in a patient's tissue, blood, or other bodily fluids, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The patient monitoring system includes at least one enzymatic sensor adapted to be inserted into the patient, where it produces sensor signals related to the concentration of the substance being measured. The sensor signals are delivered through a suitable interconnect cable to a monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the enzymatic sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the substance concentration value. The substance concentration value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.

摘要翻译： 患者监测系统测量患者组织，血液或其他体液中特定物质的浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内 。 如果没有，则产生声音和/或视觉报警信号。 患者监测系统包括适于插入到患者体内的至少一个酶传感器，其中它产生与所测量物质的浓度相关的传感器信号。 传感器信号通过合适的互连电缆传输到监视器。 在一个实施例中，互连电缆包括非接触式连接器，其将酶传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 监视器通过应用先前确定的校准来定量地确定物质浓度值来解释传感器信号。 然后处理如此确定的物质浓度值以确定变化率，存储（以创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。

公开(公告)号：US06035237A

公开(公告)日：2000-03-07

申请号：US447455

申请日：1995-05-23

申请人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

发明人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

IPC分类号： A61N1/08 ,  A61N1/32 ,  A61N1/36 ,  A61N1/16

CPC分类号： A61N1/36142 ,  A61N1/36125

摘要： An implantable living tissue stimulator avoids the use of conventional coupling capacitors in its output stage, yet still prevents an average dc current flow from flowing through living tissue in electrical contact with the stimulator. The output stage generates and applies a biphasic stimulating current pulse to selected paired output terminals. The terminals, in turn, are electrically connected to respective electrodes which are positioned so as to contact the living tissue to be stimulated. In one embodiment, special circuitry is employed within the output stage to block dc current flow through the living tissue and to balance the electrical charge that is delivered to the living tissue. In another embodiment, the electrodes themselves are made from a material that allows them to function as a capacitor. In yet an additional embodiment, the coupling capacitors are integrated into the leads that connect the output terminals of the output stage with the electrodes.

摘要翻译： 植入式生物组织刺激器避免了在其输出阶段使用传统的耦合电容器，但仍然阻止平均直流电流流过活组织与刺激器电接触。 输出级产生并将双相刺激电流脉冲施加到选定的配对输出端子。 这些端子又电连接到相应的电极，这些电极定位成接触待刺激的生物体组织。 在一个实施例中，在输出级内采用特殊电路来阻止直流电流流过活组织并平衡输送到生物体组织的电荷。 在另一个实施例中，电极本身由允许它们用作电容器的材料制成。 在又一个实施例中，耦合电容器集成到将输出级的输出端与电极连接的引线中。

公开(公告)号：US5660163A

公开(公告)日：1997-08-26

申请号：US444300

申请日：1995-05-18

申请人： Joseph H. Schulman ,  Orville Rey Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

发明人： Joseph H. Schulman ,  Orville Rey Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B2562/08 ,  A61B5/742

摘要： A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.

摘要翻译： 葡萄糖监测系统连续测量患者血液中的葡萄糖浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内。 如果没有，则产生声音和/或视觉报警信号。 葡萄糖监测系统包括适于插入患者静脉系统中的葡萄糖传感器，其响应于血糖并产生与葡萄糖浓度相关的传感器信号。 传感器信号通过合适的互连电缆传送到葡萄糖监测器。 在一个实施例中，互连电缆包括非接触式连接器，其将葡萄糖传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 葡萄糖监测器通过应用预先确定的校准来定量地确定血糖值来解释传感器信号。 然后处理如此确定的血糖值以确定变化率，存储（创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。

公开(公告)号：US4808167A

公开(公告)日：1989-02-28

申请号：US4352

申请日：1987-01-16

申请人： Alfred E. Mann ,  Joseph H. Schulman

发明人： Alfred E. Mann ,  Joseph H. Schulman

IPC分类号： A61M5/00 ,  A61B19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/50 ,  A61M1/00

CPC分类号： A61M5/1413 ,  A61B2090/0814 ,  A61M5/14244 ,  A61M5/50 ,  Y10S128/12

摘要： A disposable cassette for use with a main infusion pump unit is disclosed which contains both a disposable pump and a battery, thereby requiring the simultaneous replacement of both the pump and the battery. The controller contained in the main pump unit includes a timer which prevents the cassette from being used for longer than a predetermined time, which is substantially less than the life of the battery. An interlock prevents a cassette from being reinstalled following a single use.

公开(公告)号：US5545191A

公开(公告)日：1996-08-13

申请号：US239183

申请日：1994-05-06

申请人： Alfred E. Mann ,  Joseph H. Schulman

发明人： Alfred E. Mann ,  Joseph H. Schulman

IPC分类号： A61F2/02 ,  A61F2/78 ,  H04R25/00 ,  A61F2/18

CPC分类号： A61N1/37229 ,  A61F2002/7881 ,  A61F2250/0001 ,  A61F2250/0002 ,  A61N1/36032 ,  H04R25/606 ,  Y10S128/15

摘要： A transcutaneous coupling device having an implanted unit and an external unit uses VELCRO for attaching the external unit to the skin in a proper location for optimal electromagnetic coupling between the units. The VELCRO has two surfaces, which adhere to one another, one surface being affixed to the external unit, and the other surface being adhesively attached to the skin. In one embodiment, the VELCRO is a patch coextensive with the surface area of the side of the external unit. In another embodiment, where the thickness of the VELCRO interferes with the coupling, the VELCRO takes the form of a ring or set of smaller patches permitting projecting portions of the side of the external unit to directly contact the skin for better coupling.

摘要翻译： 具有植入单元和外部单元的经皮耦合装置使用VELCRO将外部单元附接到适当位置的皮肤，以实现各单元之间的最佳电磁耦合。 VELCRO具有彼此粘附的两个表面，一个表面固定到外部单元，另一个表面粘附到皮肤上。 在一个实施例中，VELCRO是与外部单元的侧面的表面积共同延伸的贴片。 在另一个实施例中，当VELCRO的厚度干扰耦合时，VELCRO采取环形或更小的组件的形式，允许外部单元的侧面的突出部分直接接触皮肤以获得更好的耦合。

公开(公告)号：US5497772A

公开(公告)日：1996-03-12

申请号：US155737

申请日：1993-11-19

申请人： Joseph H. Schulman ,  Orville R. Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

发明人： Joseph H. Schulman ,  Orville R. Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B2562/08 ,  A61B5/742

摘要： A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.

摘要翻译： 葡萄糖监测系统连续测量患者血液中的葡萄糖浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内。 如果没有，则产生声音和/或视觉报警信号。 葡萄糖监测系统包括适于插入患者静脉系统中的葡萄糖传感器，其响应于血糖并产生与葡萄糖浓度相关的传感器信号。 传感器信号通过合适的互连电缆传送到葡萄糖监测器。 在一个实施例中，互连电缆包括非接触式连接器，其将葡萄糖传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 葡萄糖监测器通过应用预先确定的校准来定量地确定血糖值来解释传感器信号。 然后处理如此确定的血糖值以确定变化率，存储（创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。

公开(公告)号：US5484404A

公开(公告)日：1996-01-16

申请号：US239357

申请日：1994-05-06

申请人： Joseph H. Schulman ,  Alfred E. Mann

发明人： Joseph H. Schulman ,  Alfred E. Mann

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61B5/6865 ,  A61N1/05

摘要： A replaceable catheter system provides a way to replace an implantable sensor, electrode system, and/or fluid delivery/receiving system. The replaceable catheter includes an elongated tubular catheter holder for surgical implantation in a patient. The catheter holder has an open neck at a proximal end thereof just under the patient's skin. A distal end of the catheter holder extends into a body cavity in the patient. A manually replaceable catheter is inserted through a self-sealing barrier over the open end of the catheter holder. A distal end of the replaceable catheter extends longitudinally through the catheter holder and beyond the distal end thereof to expose one or more physiological/chemical sensors, tissues stimulating electrodes, and/or a fluid delivery/receiving tube carried by or formed within the replaceable catheter. The sensors and/or electrodes are electrically connected to an electronic package including a signal coupler adjacent a signal coupler carried by the catheter holder. The signal coupler is connected to an implanted control device whereby electrical signals are transmitted to and/or from the sensor and/or electrode from the control device. The control device may include, or be connected to, an implantable fluid dispenser/analyzer for dispensing or analyzing fluid via a conduit connected through the catheter holder to an opening in the replaceable catheter.

摘要翻译： 可替换的导管系统提供了替代可植入传感器，电极系统和/或流体递送/接收系统的方法。 可更换的导管包括用于患者手术植入的细长管状导管保持器。 导管保持器在其刚好在患者皮肤下方的近端处具有开口的颈部。 导管保持器的远端延伸到患者体内的体腔中。 可手动更换的导管穿过导管保持器的开口端上的自密封屏障插入。 可替换导管的远端纵向延伸穿过导管保持器并且超过其远端以暴露一个或多个生理/化学传感器，刺激电极的组织和/或由可更换导管承载或形成的流体输送/接收管 。 传感器和/或电极电连接到电子封装，该电子封装包括邻近由导管保持器承载的信号耦合器的信号耦合器。 信号耦合器连接到植入的控制装置，由此电信号从控制装置传送到传感器和/或电极。 控制装置可以包括或连接到可植入流体分配器/分析器，用于经由通过导管保持器连接的导管分配或分析流体到可更换导管中的开口。

公开(公告)号：US6067474A

公开(公告)日：2000-05-23

申请号：US126615

申请日：1998-07-31

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  Alfred E. Mann ,  Michael A. Faltys

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  Alfred E. Mann ,  Michael A. Faltys

IPC分类号： A61F2/02 ,  A61F2/18 ,  A61F11/00 ,  A61N1/08 ,  A61N1/36 ,  A61N1/375 ,  A61N1/378 ,  H01M2/10 ,  H01M4/02 ,  H01M6/10 ,  H01M10/04 ,  H01M10/34 ,  H01M10/46 ,  H02J7/00 ,  H02J7/02 ,  H02J17/00 ,  A61N1/34

CPC分类号： A61N1/08 ,  A61N1/36032 ,  A61N1/375 ,  A61N1/3787 ,  H01M10/0436 ,  H01M10/46 ,  H01M4/02 ,  H02J7/025 ,  H01M10/345 ,  H01M2/1022 ,  H01M2/1066 ,  H01M2004/025 ,  H01M6/10

摘要： An implantable system, such as a neural stimulator or a cochlear implant system, includes a rechargeable battery configuration having improved recharging and lifetime characteristics. The battery is housed within the implant's case and has first and second electrode plates. Each electrode plate has a plurality of slits that extend across a substantial portion of the plate's surface area. The slits in the electrode plates reduce the magnitude of eddy currents induced in the plates by external ac magnetic fields allowing faster battery recharging times. Alternatively, the electrode plates are wrapped in a spiral configuration such that, in the plane of the spiral, the electrode plates have a small cross-sectional area and no closed current loops. Additionally, the implant device may be housed in a case formed of a high-resistivity material and a circuit included in the implant device is configured to avoid large current loops that would result in eddy current heating. As a backup option, the circuitry of the implant device may optionally be powered from an external battery that inductively couples energy to the same coil that is used to charge the internal battery. In one embodiment, the implantable system is partitioned into first and second implantable cases, each having electrical circuitry therein, and only one having a rechargeable power source therein, facilitating its subsequent replacement for repair or upgrading purposes. The two cases are coupled together when the system is in use. Coupling is achieved either magnetically and/or with a detachable electrical cable. In one embodiment, power is transferred from one implant case to the other using a 3-phase transmission scheme.

摘要翻译： 诸如神经刺激器或人工耳蜗植入系统的可植入系统包括具有改善的再充电和寿命特性的可再充电电池配置。 电池容纳在植入物壳体内并具有第一和第二电极板。 每个电极板具有延伸穿过板的表面区域的大部分的多个狭缝。 电极板中的狭缝通过外部交流磁场减小板中感应的涡流的大小，从而允许更快的电池充电时间。 或者，电极板被卷绕成螺旋构造，使得在螺旋的平面中，电极板具有小的横截面积并且没有闭合电流环路。 另外，植入装置可以容纳在由高电阻率材料形成的壳体中，并且包括在植入装置中的电路被配置为避免将导致涡流加热的大电流环路。 作为备用选项，植入装置的电路可以可选地由外部电池供电，外部电池将能量耦合到用于对内部电池充电的相同线圈。 在一个实施例中，可植入系统被划分成第一和第二可植入壳体，每个壳体具有电路，并且只有一个在其中具有可再充电的电源，便于其随后的修理或升级目的的更换。 当系统使用时，这两种情况耦合在一起。 通过磁性和/或可拆卸电缆实现耦合。 在一个实施例中，使用3相传输方案将功率从一个植入壳体传送到另一个。

公开(公告)号：US5651767A

公开(公告)日：1997-07-29

申请号：US587881

申请日：1996-01-11

申请人： Joseph H. Schulman ,  Alfred E. Mann ,  Charles L. Byers ,  Jack W. Love

发明人： Joseph H. Schulman ,  Alfred E. Mann ,  Charles L. Byers ,  Jack W. Love

IPC分类号： A61N1/05 ,  A61M5/00

CPC分类号： A61N1/05 ,  A61B5/6865

摘要： A replaceable catheter system provides a way to replace an implantable sensor, electrode system, and/or fluid delivery/receiving system. The replaceable catheter system includes an implantable shunt, such as an arteriovenous shunt, attached to an implantable introducer. The introducer and implantable shunt are adapted for surgical implantation within a patient such that it extends from immediately below the patient's skin to the implantable shunt site. The replaceable catheter system further includes a replaceable catheter that is adapted to be contained within the introducer and properly aligned such that an implantable sensor, electrode system, and/or fluid delivery system that is carried by the replaceable catheter is placed in operative association with the implantable shunt and exposed to any fluids passing through the implantable shunt.

摘要翻译： 可替换的导管系统提供了替代可植入传感器，电极系统和/或流体递送/接收系统的方法。 可替换的导管系统包括可植入的分流器，例如静脉分流器，其附接到可植入导引器。 导引器和可植入分流装置适于在患者体内进行手术植入，使得其从患者皮肤的正下方延伸到可植入分流部位。 可替换的导管系统还包括可更换的导管，其适于容纳在导引器内并且适当对准，使得由可更换导管携带的可植入传感器，电极系统和/或流体输送系统与 可植入分流器并暴露于通过可植入分流器的任何流体。

公开(公告)号：US4082097A

公开(公告)日：1978-04-04

申请号：US688411

申请日：1976-05-20

申请人： Alfred E. Mann ,  Joseph H. Schulman

发明人： Alfred E. Mann ,  Joseph H. Schulman

IPC分类号： A61N1/378 ,  H02J7/02 ,  A61N1/36

CPC分类号： H02J7/025 ,  A61N1/3787 ,  H02J7/022 ,  Y10S320/21

摘要： A system is disclosed for controlling the charging of a rechargeable battery in an implanted human tissue stimulator by means of an external power source. Included in the stimulator are battery protection devices designed to sense the state of charge of the battery and limit the charging currrent amplitude so as not to exceed a selected maximum based on different criteria including battery state of charge signals from the implanted stimulator which are indicative of the current amplitude and battery state of charge from one of the protection devices are transmited to an external unit. Based on these signals the external unit is operated in one of a plurality of modes to cause the battery to be charged by a current with an optimum safe amplitude irrespective of determined failure of one or more of the battery protection devices.