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1.发明申请AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 失效2-和/或4-取代的安慰剂和安慰剂作为心血管疾病药物的氨基酸衍生物公开(公告)号：US20100324003A1
公开(公告)日：2010-12-23
申请号：US12680988
申请日：2008-09-18
申请人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Giuseppe Marazzi , Marco Torri , Walter Cabri
发明人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Giuseppe Marazzi , Marco Torri , Walter Cabri
IPC分类号： A61K31/58 , C07J41/00 , C07J43/00 , C07J71/00 , C07J53/00 , A61K31/5685 , A61P9/12 , A61P9/00
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译： 2-和/或4-取代的雄甾烷和雄甾烯-3的位置3上的新的氨基肟衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。 特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。
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2.发明授权Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders 失效作为心血管疾病药物的2-和/或4-取代的雄甾烷和雄激素的氨基肟衍生物公开(公告)号：US08664210B2
公开(公告)日：2014-03-04
申请号：US12680988
申请日：2008-09-18
申请人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
发明人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译： 2-和/或4-取代的雄甾烷和雄甾烯-3的位置3上的新的氨基肟衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。 特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。
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3.发明申请AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权安非他酮和安慰剂作为心血管疾病药物的偶氮胆碱衍生物公开(公告)号：US20090275542A1
公开(公告)日：2009-11-05
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译： 式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。 这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。 它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿以及肾衰竭进展 adducin多态性。
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4.发明授权Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders 有权雄激素和雄激素的氮杂环基衍生物作为心血管疾病的药物公开(公告)号：US08536160B2
公开(公告)日：2013-09-17
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译： 式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。 这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。 它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿和肾衰竭进展 adducin多态性。
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5.发明授权Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them 失效对心血管系统活化的半胱固醇类固醇，其制备方法和含有它们的药物组合物
公开(公告)号：US5955632A
公开(公告)日：1999-09-21
申请号：US891033
申请日：1997-07-10
申请人： Mauro Gobbini , Sergio De Munari , Giorgio Fedrizzi , Patrizia Ferrari , Piero Melloni , Marco Santagostino , Marco Torri
发明人： Mauro Gobbini , Sergio De Munari , Giorgio Fedrizzi , Patrizia Ferrari , Piero Melloni , Marco Santagostino , Marco Torri
IPC分类号： A61K31/045 , A61K31/13 , A61K31/155 , A61P9/00 , A61P9/12 , C07C251/38 , C07C251/58 , C07C281/18 , C07D295/04 , A61K31/495 , C07C291/00 , C07D211/06
CPC分类号： C07C281/18 , C07C251/58 , C07C2103/26
摘要： New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##
摘要翻译： 提供新的seco-D类固醇衍生物，其制备方法和药物组合物，其在心血管系统上具有活性。 次级D类固醇衍生物具有以下通式（I）：
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6.发明授权Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders 失效二氧硫氧还蛋白和二氢二脱氧核苷酸3β衍生物和包含其的医药组合物用于治疗心血管疾病
公开(公告)号：US5478817A
公开(公告)日：1995-12-26
申请号：US79942
申请日：1993-06-23
申请人： Piero Melloni , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Loredana Valentino
发明人： Piero Melloni , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Loredana Valentino
IPC分类号： A61K31/585 , A61K31/58 , A61P9/00 , A61P9/12 , C07J19/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07D307/58
CPC分类号： C07J19/00 , C07J31/003 , C07J41/0055 , C07J41/0088 , C07J43/003
摘要： Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.
摘要翻译： 公开了Digitoxigenin和二氢igitoxigenin3β衍生物，其制备方法和含有其的治疗心血管疾病如心力衰竭和高血压的药物组合物。
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7.发明授权Seco-D steroids active on the cardiovascular system and pharmaceutical compositions containing same 失效对于心血管系统活化的Seco-D类固醇和含有它的药物组合物
公开(公告)号：US5731345A
公开(公告)日：1998-03-24
申请号：US632124
申请日：1996-04-15
申请人： Mauro Gobbini , Patrizia Ferrari , Piero Melloni , Marco Torri
发明人： Mauro Gobbini , Patrizia Ferrari , Piero Melloni , Marco Torri
IPC分类号： C07D307/33 , A61K31/34 , A61K31/341 , A61P9/00 , A61P9/12 , C07D307/42 , C07D307/46 , C07D307/52 , C07D307/54 , A61K31/365 , C07D307/58
CPC分类号： C07D307/42 , C07D307/46 , C07D307/52 , C07D307/54
摘要： Seco-D steroid derivatives having the formula ##STR1## wherein R, R.sup.1, R.sup.2 and R.sup.3 have the meanings specified in the specification, useful as cardiovascular agents and pharmaceutical compositions containing same, are disclosed.
摘要翻译： 公开了具有式“IMAGE”的山高-D类固醇衍生物，其中R，R 1，R 2和R 3具有本说明书中规定的含义，可用作心血管药剂和含有其的药物组合物。
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8.发明授权Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them 失效非胆酸衍生物，其制备方法及其用途和含有它们的药物组合物
公开(公告)号：US4895836A
公开(公告)日：1990-01-23
申请号：US133043
申请日：1987-10-29
申请人： Laura Chiodini , Mauro Gobbini , Sergio Mantegani , Daniel Ruggieri , Aldemio Temperilli , Gabriella Traquandi , Patrizia Ferrari
发明人： Laura Chiodini , Mauro Gobbini , Sergio Mantegani , Daniel Ruggieri , Aldemio Temperilli , Gabriella Traquandi , Patrizia Ferrari
IPC分类号： A61K31/575 , C07J1/00 , C07J41/00
CPC分类号： C07J41/0088 , C07J41/0055
摘要： ##STR1## Compounds I (either R
1 =OH, C
1 -C
4 alkoxy and R
2 =H, C
1 -C
4 alkyl, or R
1 +R
2 =a chemical bond; R
3 =an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being α or β: and either R
4 =OH and R
5 =H or R
4 +R
5 =a chemical bond) and their pharmaceutically acceptable salts are useful as antihypertensive agents. Their preparation and use as well as pharmaceutical compositions containing them are also described.摘要翻译： PCT No.PCT / EP87 / 00006 Sec。 371日期1987年10月29日第 102（e）1987年10月29日PCT PCT 1987年1月7日PCT公布。 出版物WO87 / 04166 日期1987年7月16日。化合物I（R1 = OH，C1-C4烷氧基和R2 = H，C1-C4烷基或R1 + R2 =化学键; R3 =氨基脱氧或氨基二脱氧或氨基歧氮 D和L系列的糖残基，糖苷键为α或β：R4 = OH和R5 = H或R4 + R5 =化学键）及其药学上可接受的盐可用作抗高血压药。 还描述了它们的制备和用途以及含有它们的药物组合物。
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9.发明授权
公开(公告)号：US5596110A
公开(公告)日：1997-01-21
申请号：US405354
申请日：1995-03-16
申请人： Mauro Gobbini , Marco Torri
发明人： Mauro Gobbini , Marco Torri
CPC分类号： C07J71/0005 , C07J15/00 , C07J19/00 , C07J3/00 , C07J3/005 , C07J5/0015
摘要： An improvement in a process for producing 3.beta.,14.beta.-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO.sub.2 hydrate or RuCl.sub.3 with the alkaline periodate.
摘要翻译： 公开了生产3β，14β-二羟基硫代乙醛的方法的改进，其中在碱催化量的四氧化钌存在下，用碱性高碘酸盐进行氧化氧代辛-3-乙酸内酯环，其原位通过使 RuO2水合物或RuCl3与碱性高碘酸盐。
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10.发明授权Cyclopentanperhydrophenanthren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders 失效环戊二氢海藻灰17β-（3-呋喃基）-3-衍生物和包含其的用于治疗心血管疾病的药物组合物
公开(公告)号：US5432169A
公开(公告)日：1995-07-11
申请号：US81111
申请日：1993-06-25
申请人： Luisa Quadri , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Piero Melloni , Loredana Valentino
发明人： Luisa Quadri , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Piero Melloni , Loredana Valentino
CPC分类号： C07J31/003 , C07J17/00 , C07J41/0055 , C07J41/0088 , C07J43/003 , C07J71/0021
摘要： Cyclopentanperhydrophenantren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension, are disclosed.
摘要翻译： 公开了环戊二氢苯丙氨酸-17β-（3-呋喃基）-3-衍生物和含有其用于治疗心力衰竭和高血压的心血管疾病的药物组合物。
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