发明申请
- 专利标题: AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS
- 专利标题(中): 安非他酮和安慰剂作为心血管疾病药物的偶氮胆碱衍生物
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申请号: US12296532申请日: 2007-04-11
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公开(公告)号: US20090275542A1公开(公告)日: 2009-11-05
- 发明人: Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
- 申请人: Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
- 申请人地址: IT Roma
- 专利权人: Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
- 当前专利权人: Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
- 当前专利权人地址: IT Roma
- 优先权: EP06112605.8 20060413
- 国际申请: PCT/EP2007/053521 WO 20070411
- 主分类号: A61K31/58
- IPC分类号: A61K31/58 ; C07J43/00 ; A61P9/04 ; A61P9/12
摘要:
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
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