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1.发明授权Composition comprising an aqueous dispersion of lipid vesicles encapsulating a UV screening agent with acidic functionality, and usess in topical application 失效包含包封具有酸性官能团的UV筛选剂的脂质囊泡的水性分散体的组合物，以及在局部应用中的用途
公开(公告)号：US5759526A
公开(公告)日：1998-06-02
申请号：US755314
申请日：1996-11-22
摘要： A composition comprising an aqueous dispersion of lipid vesicles encapsulating at least one compound which screens out UV radiation and contains at least one free or at least partially neutralized acidic function, wherein the lipid vesicles have a lipid membrane formed from at least one nonionic amphiphilic lipid (A) or from at least one saturated hydrocarbon ionic amphiphilic lipid (B) having an iodine number of less than 10, and from at least one totally neutralized ionic amphiphilic lipid (C) is disclosed. The use of this composition as a base for products to care for the skin, the scalp, the hair, the eyelashes or the eyebrows, as a base for make-up products, and more particularly as bases for compositions to protect the human epidermis, the hair, the eyelashes or the eyebrows against ultraviolet rays are also disclosed.
摘要翻译： 一种组合物，其包含脂质囊泡的水性分散体，其包封至少一种筛选紫外线辐射并且含有至少一种游离或至少部分中和的酸性功能的化合物，其中所述脂质囊泡具有由至少一种非离子两亲性脂质形成的脂质膜 A）或至少一种碘值小于10的饱和烃离子两亲性脂质（B）和至少一种完全中和的离子两亲性脂质（C）。 使用该组合物作为产品护理皮肤，头皮，头发，睫毛或眉毛的基质，作为化妆品的基质，更特别地，作为保护人类表皮的组合物的基质， 还公开了头发，睫毛或眉毛防紫外线。
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2.发明授权Transparent nanoemulsion less than 100 NM based on fluid non-ionic amphiphilic lipids and use in cosmetic or in dermopharmaceuticals 失效透明纳米乳液基于流体非离子两亲脂质小于100NM，用于化妆品或皮肤药物
公开(公告)号：US5753241A
公开(公告)日：1998-05-19
申请号：US607353
申请日：1996-02-26
IPC分类号： A61K9/107 , A61K8/06 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/46 , A61K8/49 , A61K8/86 , A61K8/97 , A61Q19/00 , B01F3/08 , B01F17/20 , B01F17/38 , B01J13/00 , A61K6/00 , A01N37/02 , A61K31/74
CPC分类号： A61Q5/00 , A61K8/062 , A61K8/375 , A61K8/39 , A61Q19/00 , B82Y5/00 , A61K2800/21 , A61K2800/262 , A61K2800/413 , Y10S514/873 , Y10S514/938
摘要： An oil-in-water nanoemulsion in which the oil globules have a mean size of less than 100 nm and which contains an amphiphilic lipid component containing at least one non-ionic amphiphilic lipid which is liquid at an ambient temperature of less than 45.degree. C. The nanoemulsion can be used in the fields of cosmetics and dermopharmaceuticals. The nanoemulsion is stable on storage, can contain significant amounts of oil while retaining good transparency, and can contain heat-sensitive active agents.
摘要翻译： 一种水包油纳米乳液，其中油球的平均粒径小于100nm，其中含有至少一种在室温低于45℃时为液体的至少一种非离子两亲性脂质的两亲性脂质成分 纳米乳液可用于化妆品和皮肤药物领域。 纳米乳剂在储存时稳定，可以含有大量的油，同时保持良好的透明度，并且可以含有热敏性活性剂。
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3.发明授权Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields 失效基于葡萄糖的烷氧基化烯基琥珀酸酯或烷氧基化烯基琥珀酸盐的纳米乳液及其在化妆品，皮肤病学，眼科学和/或药物领域中的用途公开(公告)号：US06461625B1
公开(公告)日：2002-10-08
申请号：US09489839
申请日：2000-01-24
IPC分类号： A61K600
CPC分类号： C07D401/06 , Y10S514/844 , Y10S514/873 , Y10S514/937 , Y10S514/938 , Y10S514/939
摘要： A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.
摘要翻译： 纳米乳剂，其平均粒径小于100nm的纳米乳液，包含选自烷氧基化烯基琥珀酸盐，葡萄糖的烷氧基化烯基琥珀酸盐和甲基葡萄糖的烷氧基化烯基琥珀酸盐的表面活性剂，以及至少一种具有分子 重量大于400，油相量与表面活性剂的重量比为2至10.所获得的乳液在储存时是透明和稳定的。 它可以包含大量的油，同时保持良好的透明度并且同时具有良好的化妆品性质。 它可以构成用于局部使用的组合物，药物组合物或眼科学组合物。
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4.发明授权Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the cosmetics, dermatological and/or ophthalmological fields 有权基于乙氧基化脂肪醚或乙氧基化脂肪酯的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用公开(公告)号：US06375960B1
公开(公告)日：2002-04-23
申请号：US09474074
申请日：1999-12-29
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/06 , A61K9/0048 , A61K9/1075 , A61K2800/21 , A61K2800/262 , A61K2800/413 , A61Q1/14 , A61Q5/00 , A61Q19/007 , B01F17/0021 , B82Y5/00 , Y10S514/844 , Y10S514/845 , Y10S514/937 , Y10S514/938
摘要： The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to 45° C. and which is selected from the group including ethoxylated fatty ethers and ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic, opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.
摘要翻译： 本发明提供一种纳米乳液，其包括：分散在水相中的油相; 和至少一种在小于或等于45℃的温度下为固体的表面活性剂，并且其选自乙氧基化脂肪醚和乙氧基化脂肪酯，以及它们的混合物; 其中油相包括数均分子量小于100nm的油球;其中油相包含至少一种分子量大于400的油; 并且其中油相与表面活性剂的重量比为2至10.本发明还提供了制备纳米乳液的方法及其使用方法。 乳液在储存时理想的透明和稳定。 它理想地含有大量的油，同时保持良好的透明度和良好的化妆品性能。 纳米乳液在组合物中特别有用，包括局部，药物，化妆品，眼科，眼科学。 该组合物在对皮肤，毛发，头皮，粘膜和眼睛的应用中也特别有用。
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5.发明授权Nanoemulsion based on glycerol fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields 有权基于甘油脂肪酯的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用公开(公告)号：US06541018B1
公开(公告)日：2003-04-01
申请号：US09461753
申请日：1999-12-16
IPC分类号： A61K700
CPC分类号： A61Q19/00 , A61K8/062 , A61K9/0048 , A61K9/1075 , A61K2800/21 , A61K2800/413 , A61Q1/14 , A61Q19/007 , B01F17/0021 , B82Y5/00 , Y10S514/844 , Y10S514/847 , Y10S514/88 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/975
摘要： The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.
摘要翻译： 本发明提供一种纳米乳液，其包括：分散在水相中的油相; 和至少一种甘油脂肪酸酯表面活性剂，其在小于或等于45℃的温度下是固体;其中所述油相包括数均分子量小于100nm的油球;其中所述油相至少包括 一种分子量大于400的油; 并且其中油相与表面活性剂的重量比为2至10.本发明还提供了制备纳米乳液的方法及其使用方法。 理想情况下，乳液在储存时是透明和稳定的。 它理想地含有大量的油，同时保持良好的透明度和良好的化妆品性能。 纳米乳剂在化妆品和皮肤病学领域特别有用，特别是用于保湿皮肤和/或粘膜，以及用于治疗头发，在眼科领域中，作为用于治疗眼睛的眼液。
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6.发明授权Organogel comprising an oxidation-sensitive hydrophilic compound, and uses thereof, in particular cosmetic uses 失效包含氧化敏感性亲水性化合物的有机凝胶及其用途，特别是化妆品用途公开(公告)号：US06342238B1
公开(公告)日：2002-01-29
申请号：US09655855
申请日：2000-09-06
IPC分类号： A61K700
CPC分类号： A61K8/042 , A61K8/06 , A61K8/062 , A61K8/553 , A61K8/676 , A61K8/678 , A61K2800/522 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , Y10S514/844
摘要： A composition in the form of an emulsion comprising an oily phase which is dispersed, with the aid of a surfactant system, in a glycerol phase containing an oxidation-sensitive hydrophilic compound and optionally comprising at least one glycol in addition to the glycerol, characterized in that the surfactant system contains at least one surfactant capable of forming a lamellar phase on contact with the glycerol phase and having a melting point of greater than or equal to 35° C. The composition obtained has the appearance of a gel in which the hydrophilic compound is stabilized with respect to oxidation, this stabilization also being achieved under aerobic conditions. The invention also relates to the use of the said composition in order to tone the skin and/or to smooth out wrinkles and fine lines on the skin and/or to combat the harmful effects of UV radiation and pollution and/or to depigment the skin.
摘要翻译： 乳液形式的组合物，其包含油相，借助于表面活性剂体系，在含有氧化敏感性亲水性化合物的甘油相中分散，并且除甘油之外任选地还包含至少一种二醇。 表面活性剂体系含有至少一种能够与甘油相接触形成层状相并具有大于或等于35℃的熔点的表面活性剂。所获得的组合物具有凝胶的外观，其中亲水性化合物 相对于氧化是稳定的，这种稳定化也在有氧条件下实现。 本发明还涉及所述组合物用于调节皮肤和/或平滑皮肤上的皱纹和细纹和/或抵抗紫外线辐射和污染的有害影响和/或褪色皮肤的用途 。
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7.发明授权Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and its uses in the cosmetics, dermatological and/or ophthalmological fields 有权基于糖脂肪酯或糖脂肪醚的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用公开(公告)号：US06689371B1
公开(公告)日：2004-02-10
申请号：US09460092
申请日：1999-12-13
IPC分类号： A61K600
CPC分类号： A61Q19/007 , A61K8/06 , A61K8/062 , A61K8/60 , A61K8/602 , A61K2800/21 , A61K2800/413 , A61Q1/14 , A61Q5/00 , A61Q19/00 , B82Y5/00 , Y10S514/938
摘要： A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.
摘要翻译： 纳米乳液的数均粒径小于100nm的纳米乳液包含在小于或等于45℃的温度下为固体的表面活性剂，该表面活性剂选自脂肪酸的酯 以及脂肪醇和糖的糖和醚，以及至少一种分子量大于400的油，油相量与表面活性剂的重量比为2至10。 纳米乳液可以用于化妆品和皮肤病学应用，特别是用于保湿皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。
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8.发明授权Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields 失效基于脂肪酸或脂肪醇，羧酸和甘油的混合酯的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的用途公开(公告)号：US06419946B1
公开(公告)日：2002-07-16
申请号：US09459581
申请日：1999-12-13
IPC分类号： A61F200
CPC分类号： B82Y5/00 , A61K8/06 , A61K8/37 , A61K2800/21 , A61K2800/413 , A61Q1/14 , Y10S514/844 , Y10S514/937 , Y10S514/938
摘要： A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm, comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.
摘要翻译： 纳米乳液，其数均粒径小于100nm的纳米乳液包含选自脂肪酸或脂肪醇的混合酯，羧酸和甘油的表面活性剂和至少一种含有 分子量大于400，油相量与表面活性剂的重量比为2至10.纳米乳液可用于例如化妆品和皮肤病学领域，特别是用于保湿 皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。
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9.发明授权Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the cosmetics, dermatological and/or ophthalmological fields 失效基于环氧乙烷和环氧丙烷嵌段共聚物的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用公开(公告)号：US06464990B2
公开(公告)日：2002-10-15
申请号：US09477715
申请日：2000-01-05
IPC分类号： A61K600
CPC分类号： B82Y5/00 , A61K8/062 , A61K8/90 , A61K9/0048 , A61K9/1075 , A61K31/77 , A61K2800/21 , A61K2800/413 , A61Q1/14 , B01F17/0028 , Y10S514/873 , Y10S514/937 , Y10S514/938
摘要： A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant comprised of polyethylene oxide and polypropylene oxide blocks, the oily phase comprising at least one oil having a molecular weight of greater than 400 and wherein the ratio by weight of the amount of oily phase to the amount of surfactant ranges from 2 to 10.
摘要翻译： 一种纳米乳液，其包含分散在水相中的油相，并且具有小于100mm的数均粒径的油球，所述分散体由包含聚环氧乙烷和聚环氧丙烷嵌段的表面活性剂促进，所述油相包含至少一种 分子量大于400的油，其中油相量与表面活性剂的重量比为2至10。
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10.发明授权Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and its uses in the cosmetics, dermatological and/or ophthalmological fields 有权基于糖脂肪酯或糖脂肪醚的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用公开(公告)号：US08834903B2
公开(公告)日：2014-09-16
申请号：US10724826
申请日：2003-12-02
CPC分类号： A61Q19/007 , A61K8/06 , A61K8/062 , A61K8/60 , A61K8/602 , A61K2800/21 , A61K2800/413 , A61Q1/14 , A61Q5/00 , A61Q19/00 , B82Y5/00 , Y10S514/938
摘要： A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.
摘要翻译： 纳米乳液的数均粒径小于100nm的纳米乳液包含在小于或等于45℃的温度下为固体的表面活性剂，该表面活性剂选自脂肪酸的酯 以及脂肪醇和糖的糖和醚，以及至少一种分子量大于400的油，油相量与表面活性剂的重量比为2至10。 纳米乳液可以用于化妆品和皮肤病学应用，特别是用于保湿皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。
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