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公开(公告)号：US10562976B2
公开(公告)日：2020-02-18
申请号：US16166220
申请日：2018-10-22
Applicant: Academia Sinica
Inventor： An-Suei Yang , Wei-Ying Kuo , Hung-Ju Hsu , Hong-Sen Chen , Yu-Chi Chou , Yueh-Liang Tsou , Hung-Pin Peng , Jhih-Wei Jian , Chung-Ming Yu , Yi-Kai Chiu , Ing-Chein Chen , Chao-Ping Tung , Michael Hsiao , Hwei-Jiung Wang
Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.
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公开(公告)号：US20140335156A1
公开(公告)日：2014-11-13
申请号：US14253977
申请日：2014-04-16
Applicant: Academia Sinica
Inventor： Olga K. Kosheleva , Peter Lai , Nelson G. Chen , Michael Hsiao , Chung-Hsuan Chen
IPC: A61K9/00
CPC classification number: A61K41/0033 , A61K41/0028 , A61K47/6923 , A61N7/00 , A61N7/02 , Y10S977/773 , Y10S977/911
Abstract: Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
Abstract translation: 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来杀死受试者的癌细胞和治疗癌症的方法。 纳米颗粒可以是金，氧化铁，铜，银，聚苯乙烯，PEG或脂质体纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。
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Patent Agency Ranking
公开(公告)号：US11981846B2
公开(公告)日：2024-05-14
申请号：US17611896
申请日：2020-07-29
Applicant: Academia Sinica
Inventor： Michael Hsiao , Ming-Hsien Chan , Subbiramaniyan Kubendhiran , Ming-Che Hsieh , Zhen Bao , An-Bang Wang , Ru-Shi Liu
CPC classification number: C09K11/025 , C09K11/565 , C09K11/70 , C09K11/7773 , C09K11/883 , G01N33/587 , G01N33/588 , B82Y20/00 , B82Y40/00 , G01N2458/00
Abstract: Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.
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公开(公告)号：US11717801B2
公开(公告)日：2023-08-08
申请号：US17625349
申请日：2020-08-05
Applicant: Academia Sinica
Inventor： Michael Hsiao , Ming-Che Hsieh , Zhen Bao , Ming-Hsien Chan , Ru-Shi Liu , An-Bang Wang , Chia-Chih Chu
IPC: B01J19/00
CPC classification number: B01J19/0093 , B01J2219/00873 , B01J2219/00957 , B01J2219/00961 , B01J2219/00963 , B01J2219/00972
Abstract: Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.
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公开(公告)号：US09427466B2
公开(公告)日：2016-08-30
申请号：US14808940
申请日：2015-07-24
Applicant: Academia Sinica
Inventor： Olga K. Kosheleva , Peter Lai , Nelson G. Chen , Michael Hsiao , Chung-Hsuan Chen
CPC classification number: A61K41/0033 , A61K41/0028 , A61K47/6923 , A61N7/00 , A61N7/02 , Y10S977/773 , Y10S977/911
Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
Abstract translation: 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来减少受试者的乳腺癌细胞生长的方法。 纳米颗粒可以是金或磁性纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。
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公开(公告)号：US20150328485A1
公开(公告)日：2015-11-19
申请号：US14808940
申请日：2015-07-24
Applicant: Academia Sinica
Inventor： Olga K. Kosheleva , Peter Lai , Nelson G. Chen , Michael Hsiao , Chung-Hsuan Chen
CPC classification number: A61K41/0033 , A61K41/0028 , A61K47/6923 , A61N7/00 , A61N7/02 , Y10S977/773 , Y10S977/911
Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
Abstract translation: 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来减少受试者的乳腺癌细胞生长的方法。 纳米颗粒可以是金或磁性纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。
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公开(公告)号：US09138476B2
公开(公告)日：2015-09-22
申请号：US14253977
申请日：2014-04-16
Applicant: Academia Sinica
Inventor： Olga K. Kosheleva , Peter Lai , Nelson G. Chen , Michael Hsiao , Chung-Hsuan Chen
CPC classification number: A61K41/0033 , A61K41/0028 , A61K47/6923 , A61N7/00 , A61N7/02 , Y10S977/773 , Y10S977/911
Abstract: Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
Abstract translation: 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来杀死受试者的癌细胞和治疗癌症的方法。 纳米颗粒可以是金，氧化铁，铜，银，聚苯乙烯，PEG或脂质体纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。
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