公开(公告)号：US11981846B2

公开(公告)日：2024-05-14

申请号：US17611896

申请日：2020-07-29

申请人： Academia Sinica

发明人： Michael Hsiao ,  Ming-Hsien Chan ,  Subbiramaniyan Kubendhiran ,  Ming-Che Hsieh ,  Zhen Bao ,  An-Bang Wang ,  Ru-Shi Liu

IPC分类号： C09K11/02 ,  C09K11/56 ,  C09K11/70 ,  C09K11/77 ,  C09K11/88 ,  G01N33/58 ,  B82Y20/00 ,  B82Y40/00

CPC分类号： C09K11/025 ,  C09K11/565 ,  C09K11/70 ,  C09K11/7773 ,  C09K11/883 ,  G01N33/587 ,  G01N33/588 ,  B82Y20/00 ,  B82Y40/00 ,  G01N2458/00

摘要： Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.

公开(公告)号：US11717801B2

公开(公告)日：2023-08-08

申请号：US17625349

申请日：2020-08-05

申请人： Academia Sinica

发明人： Michael Hsiao ,  Ming-Che Hsieh ,  Zhen Bao ,  Ming-Hsien Chan ,  Ru-Shi Liu ,  An-Bang Wang ,  Chia-Chih Chu

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00873 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00972

摘要： Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.