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公开(公告)号：US20150376286A1
公开(公告)日：2015-12-31
申请号：US14752493
申请日：2015-06-26
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, JR. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
摘要翻译： 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。
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公开(公告)号：US20210179722A1
公开(公告)日：2021-06-17
申请号：US17111442
申请日：2020-12-03
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, JR. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20210040189A1
公开(公告)日：2021-02-11
申请号：US17015212
申请日：2020-09-09
申请人： AMGEN INC.
IPC分类号： C07K16/18 , C07K16/22 , A61K39/395
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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公开(公告)号：US20210179723A1
公开(公告)日：2021-06-17
申请号：US17111453
申请日：2020-12-03
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, Jr. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20180142029A1
公开(公告)日：2018-05-24
申请号：US15824827
申请日：2017-11-28
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, JR. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20180111985A1
公开(公告)日：2018-04-26
申请号：US15841065
申请日：2017-12-13
申请人： Amgen Inc.
IPC分类号： C07K16/18 , C07K16/22 , A61K39/395 , A61K39/00
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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