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公开(公告)号：US20210179722A1
公开(公告)日：2021-06-17
申请号：US17111442
申请日：2020-12-03
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, JR. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20170267769A1
公开(公告)日：2017-09-21
申请号：US15601868
申请日：2017-05-22
申请人： Amgen Inc.
发明人： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20140004107A1
公开(公告)日：2014-01-02
申请号：US13897096
申请日：2013-05-17
申请人： Amgen Inc.
发明人： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
摘要翻译： 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20170002079A1
公开(公告)日：2017-01-05
申请号：US15178652
申请日：2016-06-10
申请人： Amgen Inc.
发明人： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
摘要翻译： 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20150218284A1
公开(公告)日：2015-08-06
申请号：US14618945
申请日：2015-02-10
申请人： AMGEN INC.
IPC分类号： C07K16/30 , A61K39/395 , A61K31/5365 , A61K47/48
CPC分类号： C07K16/30 , A61K31/5365 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with CD27L expression.
摘要翻译： 本发明涉及CD27L抗原结合蛋白，如抗体，编码所述CD271抗原结合蛋白的多核苷酸，抗体药物共轭组合物，以及用于诊断和治疗与CD27L表达相关疾病的方法。
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公开(公告)号：US20220169744A1
公开(公告)日：2022-06-02
申请号：US17672889
申请日：2022-02-16
申请人： Amgen Inc.
IPC分类号： C07K16/28 , A61K39/395 , C07K16/22 , A61P37/00
摘要： Methods of treating conditions related to lung disease using an antigen binding protein specific for the Jagged1 polypeptide are provided.
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公开(公告)号：US20210179723A1
公开(公告)日：2021-06-17
申请号：US17111453
申请日：2020-12-03
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, Jr. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20180142029A1
公开(公告)日：2018-05-24
申请号：US15824827
申请日：2017-11-28
申请人： AMGEN INC.
发明人： Thomas C. BOONE , David W. BRANKOW , Colin V. GEGG, JR. , Shaw-Fen Sylvia HU , Chadwick T. KING , Hsieng Sen LU , Licheng SHI , Cen XU
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：US20220119537A1
公开(公告)日：2022-04-21
申请号：US17339301
申请日：2021-06-04
申请人： Amgen Inc.
发明人： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20210340270A1
公开(公告)日：2021-11-04
申请号：US17320128
申请日：2021-05-13
申请人： Amgen Inc.
IPC分类号： C07K16/28 , A61K39/395 , C07K16/22 , A61P37/00
摘要： Methods of treating conditions related to lung disease using an antigen binding protein specific for the Jagged1 polypeptide are provided.
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