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    HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETTA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF
    2.
    发明申请
    HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETTA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF 审中-公开
    人类抗原结合蛋白，其包含KLOTHO，FGF受体及其复合物

    公开(公告)号：US20170015750A1

    公开(公告)日：2017-01-19

    申请号：US15280662

    申请日：2016-09-29

    Applicant: AMGEN INC.

    Inventor： Shaw-Fen Sylvia HU ,  Ian Nevin FOLTZ ,  Chadwick Terence KING ,  Yang LI ,  Taruna Arora

    IPC: C07K16/28

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

    Abstract translation: 本发明提供与抗原结合蛋白有关或衍生自抗原结合蛋白的组合物和方法激活FGF21介导的信号传导。 在实施方案中，抗原结合蛋白特异性结合（i）β-Klotho; （ii）FGFR1c，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4之一的复合物。 在一些实施方案中，抗原结合蛋白诱导FGF21样信号传导。 在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，所述抗体的结合片段和衍生物，以及特异性结合（i）β-Klotho的多肽; （ii）FGFR1c，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4之一的复合物。 其它实施方案提供了编码这种抗原结合蛋白的核酸及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物以及多肽，以及使用这些抗原结合蛋白的方法 ，其片段及其衍生物和多肽，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症的受试者的方法。

    ANTIGEN BINDING PROTEINS THAT BIND PAR-2
    8.
    发明申请
    ANTIGEN BINDING PROTEINS THAT BIND PAR-2 审中-公开
    抗体结合蛋白质，包括PAR-2

    公开(公告)号：US20140170166A1

    公开(公告)日：2014-06-19

    申请号：US13910413

    申请日：2013-06-05

    Applicant: Amgen Inc.

    Inventor： G. Duke VIRCA ,  Shaw-Fen Sylvia HU

    IPC: C07K16/28

    CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/30

    Abstract: The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.

    Abstract translation: 本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。 在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断患有PAR-2相关疾病或病症的受试者。

    ANTIBODIES THAT BIND PAR-2
    9.
    发明申请
    ANTIBODIES THAT BIND PAR-2 审中-公开
    BIND PAR-2的抗体

    公开(公告)号：US20130189281A1

    公开(公告)日：2013-07-25

    申请号：US13629373

    申请日：2012-09-27

    Applicant: Amgen Inc.

    Inventor： George Duke VIRCA ,  Shaw-Fen Sylvia HU

    IPC: C07K16/28

    CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

    Abstract: The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.

    Abstract translation: 本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。 在具体实施方案中，本发明提供了结合人PAR-2，PAR-2-结合片段和此类抗体衍生物的抗体，以及包含此类片段的PAR-2结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断患有PAR-2相关疾病或病症的受试者。

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