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公开(公告)号：US20140302036A1
公开(公告)日：2014-10-09
申请号：US14203123
申请日：2014-03-10
申请人： Amgen Inc.
IPC分类号： C07K16/24 , C07K16/46 , A61K45/06 , C07K16/22 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2827 , C07K16/2875 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/94 , C07K2318/10 , C07K2319/70
摘要： Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
摘要翻译： 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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公开(公告)号：US20150044235A1
公开(公告)日：2015-02-12
申请号：US14285576
申请日：2014-05-22
申请人： Amgen Inc.
发明人： Kenneth W. WALKER , Yue-Sheng LI , Thomas Charles BOONE , George DOELLGAST (DECEASED) , HoSung MIN , Jane TALVENHEIMO , Taruna ARORA , Frederick W. JACOBSEN
IPC分类号： C07K16/44 , C07K14/575 , C07K14/605 , C07K16/24 , C07K14/435 , C07K16/18
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：US20210040189A1
公开(公告)日：2021-02-11
申请号：US17015212
申请日：2020-09-09
申请人： AMGEN INC.
IPC分类号： C07K16/18 , C07K16/22 , A61K39/395
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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公开(公告)号：US20190192628A1
公开(公告)日：2019-06-27
申请号：US16297494
申请日：2019-03-08
申请人： AMGEN INC.
IPC分类号： A61K38/18 , C07K16/00 , A61K47/68 , C07K14/475
CPC分类号： A61K38/18 , A61K47/48376 , A61K47/6801 , C07K14/475 , C07K16/00 , C07K2317/52 , C07K2317/526 , C07K2319/30
摘要： This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
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公开(公告)号：US20180111985A1
公开(公告)日：2018-04-26
申请号：US15841065
申请日：2017-12-13
申请人： Amgen Inc.
IPC分类号： C07K16/18 , C07K16/22 , A61K39/395 , A61K39/00
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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公开(公告)号：US20170190793A1
公开(公告)日：2017-07-06
申请号：US15405233
申请日：2017-01-12
申请人： AMGEN INC.
发明人： Kenneth W. WALKER , Yue-Sheng LI , Thomas Charles BOONE , George DOELLGAST (DECEASED) , HoSung MIN , Jane TALVENHEIMO , Taruna ARORA , Frederick W. JACOBSEN
IPC分类号： C07K16/44 , C07K14/66 , C07K14/605
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：US20160193295A1
公开(公告)日：2016-07-07
申请号：US14909431
申请日：2014-07-30
申请人： AMGEN INC.
IPC分类号： A61K38/18 , A61K47/48 , C07K14/475
CPC分类号： A61K38/18 , A61K47/48376 , A61K47/6801 , C07K14/475 , C07K16/00 , C07K2317/52 , C07K2317/526 , C07K2319/30
摘要： This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
摘要翻译： 本公开提供了包含在铰链区中具有一个或多个半胱氨酸残基缺失的抗体Fc区并用一个或多个CH 3界面氨基酸的含巯基残基取代的多肽。 此外，提供了Fc融合蛋白和含有所述多肽，核酸和编码所述多肽的载体以及宿主细胞的Fc融合蛋白和制备所述多肽的方法。
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公开(公告)号：US20230128444A1
公开(公告)日：2023-04-27
申请号：US17936062
申请日：2022-09-28
申请人： AMGEN INC.
IPC分类号： C07K16/46 , A61P37/06 , A61P19/02 , A61P29/02 , A61K39/395 , C07K16/28 , C07K16/18 , C07K16/24
摘要： Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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公开(公告)号：US20150232566A1
公开(公告)日：2015-08-20
申请号：US14627992
申请日：2015-02-20
申请人： Amgen Inc.
CPC分类号： C07K16/2878 , A61K38/1767 , A61K47/6871 , A61K2039/6056 , C07K16/18 , C07K16/2866 , C07K16/2875 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/30
摘要： Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了一种分离的免疫球蛋白。 还公开了包含免疫球蛋白，编码它的分离的核酸，载体，宿主细胞的药物组合物和药物，其用于制备它的方法。 在一些实施方案中，免疫球蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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公开(公告)号：US20150044236A1
公开(公告)日：2015-02-12
申请号：US14285579
申请日：2014-05-22
申请人： AMGEN INC.
发明人： Kenneth W. WALKER , Yue-Sheng LI , Thomas Charles BOONE , HoSung MIN , Jane TALVENHEIMO , Taruna ARORA , Frederick W. JACOBSEN
IPC分类号： C07K16/44 , C07K16/24 , C07K14/575 , C07K14/605 , C07K16/18 , C07K14/435
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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