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公开(公告)号：US10800839B2
公开(公告)日：2020-10-13
申请号：US15841065
申请日：2017-12-13
Applicant: Amgen Inc.
Inventor： William Gleason Richards , Hsieng Sen Lu , Hua Zhu Ke , Chaoyang Li , Frederick W. Jacobsen
IPC: C07K16/18 , C07K16/22 , A61K39/395 , A61K39/00
Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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公开(公告)号：US09803019B2
公开(公告)日：2017-10-31
申请号：US14627992
申请日：2015-02-20
Applicant: Amgen Inc.
Inventor： Kenneth W. Walker , Frederick W. Jacobsen , Taruna Arora
CPC classification number: C07K16/2878 , A61K38/1767 , A61K47/6871 , A61K2039/6056 , C07K16/18 , C07K16/2866 , C07K16/2875 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/30
Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：US09458246B2
公开(公告)日：2016-10-04
申请号：US14203123
申请日：2014-03-10
Applicant: Amgen Inc.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
IPC: C07K16/28 , C07K16/46 , A61K39/395 , A61K45/06 , A61K39/00
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2827 , C07K16/2875 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/94 , C07K2318/10 , C07K2319/70
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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公开(公告)号：US20160024225A1
公开(公告)日：2016-01-28
申请号：US14776399
申请日：2014-03-12
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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Patent Agency Ranking
公开(公告)号：US10189912B2
公开(公告)日：2019-01-29
申请号：US15405233
申请日：2017-01-12
Applicant: AMGEN INC.
Inventor： Kenneth W. Walker , Yue-Sheng Li , Thomas Charles Boone , George Doellgast , HoSung Min , Jane Talvenheimo , Taruna Arora , Frederick W. Jacobsen
IPC: C07K16/44 , A61K39/395 , C07K16/00 , C07K16/18 , C07K14/435 , C07K14/575 , C07K14/605 , C07K16/24 , C07K14/66 , A61K47/68
Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：US09562108B2
公开(公告)日：2017-02-07
申请号：US14285579
申请日：2014-05-22
Applicant: AMGEN INC.
Inventor： Kenneth W. Walker , Yue-Sheng Li , Thomas Charles Boone , HoSung Min , Jane Talvenheimo , Taruna Arora , Frederick W. Jacobsen
IPC: C07K16/44 , A61K39/395 , C07K16/00 , C07K16/18 , C07K14/435 , C07K14/575 , C07K14/605 , C07K16/24
CPC classification number: C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
Abstract translation: 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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公开(公告)号：US12297260B2
公开(公告)日：2025-05-13
申请号：US17015212
申请日：2020-09-09
Applicant: AMGEN INC.
Inventor： William Gleason Richards , Hsieng Sen Lu , Hua Zhu Ke , Chaoyang Li , Frederick W. Jacobsen
IPC: C07K16/18 , A61K39/395 , C07K16/22 , A61K39/00
Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
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公开(公告)号：US10421823B2
公开(公告)日：2019-09-24
申请号：US14776399
申请日：2014-03-12
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
IPC: C07K16/28 , C07K16/46 , A61K39/395 , A61P37/06 , C07K16/18 , C07K16/24 , A61P29/02 , A61P19/02 , A61K39/00
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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公开(公告)号：US09562107B2
公开(公告)日：2017-02-07
申请号：US14285576
申请日：2014-05-22
Applicant: AMGEN INC.
Inventor： Kenneth W. Walker , Yue-Sheng Li , Thomas Charles Boone , George Doellgast , HoSung Min , Jane Talvenheimo , Taruna Arora , Frederick W. Jacobsen
IPC: C07K16/44 , A61K39/395 , C07K16/00 , C07K16/18 , C07K14/435 , C07K14/575 , C07K14/605 , C07K16/24
CPC classification number: C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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