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公开(公告)号：US11492417B2
公开(公告)日：2022-11-08
申请号：US16579321
申请日：2019-09-23
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick Jacobsen , Wayne Tsuji
IPC: C07K16/28 , C07K16/46 , A61P37/06 , A61P19/02 , A61P29/02 , A61K39/395 , C07K16/18 , C07K16/24 , A61K39/00
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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公开(公告)号：US20210206881A1
公开(公告)日：2021-07-08
申请号：US16579321
申请日：2019-09-23
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick Jacobsen , Wayne Tsuji
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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公开(公告)号：US20200017581A1
公开(公告)日：2020-01-16
申请号：US16576323
申请日：2019-09-19
Applicant: AMGEN INC.
Inventor： Wei-Jian Pan , Wayne Tsuji
IPC: C07K16/24
Abstract: The invention relates to products and methods for treating Crohn's disease. The products relate to antibodies that inhibit native human IL-23 while sparing IL-12. One example describes a Phase 1, randomized, double-blind, placebo-controlled, ascending multiple dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of an anti-IL-23 antibody (AMG 139) in healthy subjects and subjects with mild to severe Crohn's disease.
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公开(公告)号：US10421824B2
公开(公告)日：2019-09-24
申请号：US15258750
申请日：2016-09-07
Applicant: Amgen Inc.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick Jacobsen , Wayne Tsuji
IPC: C07K16/28 , A61K39/395 , C07K16/46 , A61K45/06 , A61K39/00
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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公开(公告)号：US10421823B2
公开(公告)日：2019-09-24
申请号：US14776399
申请日：2014-03-12
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
IPC: C07K16/28 , C07K16/46 , A61K39/395 , A61P37/06 , C07K16/18 , C07K16/24 , A61P29/02 , A61P19/02 , A61K39/00
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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Patent Agency Ranking
公开(公告)号：US20180327490A1
公开(公告)日：2018-11-15
申请号：US15819159
申请日：2017-11-21
Applicant: AMGEN INC.
Inventor： Wei-Jian Pan , Wayne Tsuji
CPC classification number: C07K16/244 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/76 , C07K2317/90 , C07K2317/94
Abstract: The invention relates to products and methods for treating Crohn's disease. The products relate to antibodies that inhibit native human IL-23 while sparing IL-12. One example describes a Phase 1, randomized, double-blind, placebo-controlled, ascending multiple dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of an anti-IL-23 antibody (AMG 139) in healthy subjects and subjects with mild to severe Crohn's disease.
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公开(公告)号：US20200283517A1
公开(公告)日：2020-09-10
申请号：US16870038
申请日：2020-05-08
Applicant: AMGEN INC.
Inventor： Wei-Jian Pan , Wayne Tsuji
IPC: C07K16/24
Abstract: The invention relates to products and methods for treating Crohn's disease. The products relate to antibodies that inhibit native human IL-23 while sparing IL-12. One example describes a Phase 1, randomized, double-blind, placebo-controlled, ascending multiple dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of an anti-IL-23 antibody (AMG 139) in healthy subjects and subjects with mild to severe Crohn's disease.
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公开(公告)号：US20170066845A1
公开(公告)日：2017-03-09
申请号：US15258750
申请日：2016-09-07
Applicant: Amgen Inc.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick Jacobsen , Wayne Tsuji
IPC: C07K16/46 , A61K45/06 , A61K39/395 , C07K16/28
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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公开(公告)号：US09458246B2
公开(公告)日：2016-10-04
申请号：US14203123
申请日：2014-03-10
Applicant: Amgen Inc.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
IPC: C07K16/28 , C07K16/46 , A61K39/395 , A61K45/06 , A61K39/00
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2827 , C07K16/2875 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/94 , C07K2318/10 , C07K2319/70
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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公开(公告)号：US20160024225A1
公开(公告)日：2016-01-28
申请号：US14776399
申请日：2014-03-12
Applicant: AMGEN INC.
Inventor： Hailing Hsu , Ming Zhang , Gunasekaran Kannan , Frederick W. Jacobsen , Wayne Tsuji
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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