公开(公告)号：US10189912B2

公开(公告)日：2019-01-29

申请号：US15405233

申请日：2017-01-12

Applicant: AMGEN INC.

Inventor： Kenneth W. Walker ,  Yue-Sheng Li ,  Thomas Charles Boone ,  George Doellgast ,  HoSung Min ,  Jane Talvenheimo ,  Taruna Arora ,  Frederick W. Jacobsen

IPC: C07K16/44 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K14/435 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24 ,  C07K14/66 ,  A61K47/68

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：US09562107B2

公开(公告)日：2017-02-07

申请号：US14285576

申请日：2014-05-22

Applicant: AMGEN INC.

Inventor： Kenneth W. Walker ,  Yue-Sheng Li ,  Thomas Charles Boone ,  George Doellgast ,  HoSung Min ,  Jane Talvenheimo ,  Taruna Arora ,  Frederick W. Jacobsen

IPC: C07K16/44 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K14/435 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.