知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.023 秒)

    Drug Condensation Aerosols And Kits
    1.
    发明申请
    Drug Condensation Aerosols And Kits 审中-公开
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US20160374937A1

    公开(公告)日：2016-12-29

    申请号：US15262954

    申请日：2016-09-12

    申请人： Alexza Pharmaceuticals, Inc.

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

    IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K31/553 ,  A61M11/04 ,  A61M11/00

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。

    Drug Condensation Aerosols And Kits
    2.
    发明申请
    Drug Condensation Aerosols And Kits 有权
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US20140060525A1

    公开(公告)日：2014-03-06

    申请号：US14078679

    申请日：2013-11-13

    申请人： Alexza Pharmaceuticals, Inc.

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

    IPC分类号： A61M11/04

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20微米的药物薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。

    Substrates for Drug Delivery Device and Methods of Preparing and Use
    4.
    发明申请
    Substrates for Drug Delivery Device and Methods of Preparing and Use 审中-公开
    用于药物输送装置的基材和制备和使用方法

    公开(公告)号：US20140072605A1

    公开(公告)日：2014-03-13

    申请号：US14078578

    申请日：2013-11-13

    申请人： ALEXZA PHARMACEUTICALS, INC.

    发明人： Bryson Bennett ,  Ron L. Hale ,  Amy Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Krishnamohan Sharma ,  Martin J. Wensley

    IPC分类号： A61K31/553 ,  A61K9/00

    CPC分类号： A61K31/553 ,  A61K9/00 ,  A61K9/007 ,  A61K9/0073 ,  A61M11/001 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047

    摘要： An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.

    摘要翻译： 公开了一种用于生产冷凝气雾剂的组件和方法。 组件包括具有耐氧化外表面的导热金属基底和外表面上的药物组合物膜，并用于气溶胶装置。 膜的厚度和基材的表面使得通过气溶剂和冷凝药物组合物形成的气溶胶含有10重量％以下的药物降解产物和药物组合物总量的至少50％ 在电影里。 用于处理外表面的方法包括加热和化学处理以及形成保护性外涂层。