公开(公告)号：US20200340920A1

公开(公告)日：2020-10-29

申请号：US16860540

申请日：2020-04-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Eunha KIM ,  Wook Kim ,  Jong Hyun Kim ,  June Sung ,  Jun Gi RHO

IPC: G01N21/64 ,  G01N33/50 ,  C09K11/06 ,  C07F7/08

Abstract: The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.

公开(公告)号：US11761894B2

公开(公告)日：2023-09-19

申请号：US16860540

申请日：2020-04-28

Applicant: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION

Inventor： Eunha Kim ,  Wook Kim ,  Jong Hyun Kim ,  June Sung ,  Jun Gi Rho

IPC: C07F7/08 ,  G01N21/64 ,  G01N33/50 ,  C09K11/06

CPC classification number: G01N21/6428 ,  C07F7/0816 ,  C09K11/06 ,  G01N21/6458 ,  G01N33/5014 ,  C09K2211/1007 ,  C09K2211/1018 ,  G01N2021/6439

Abstract: The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.