公开(公告)号：US20200340920A1

公开(公告)日：2020-10-29

申请号：US16860540

申请日：2020-04-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Eunha KIM ,  Wook Kim ,  Jong Hyun Kim ,  June Sung ,  Jun Gi RHO

IPC: G01N21/64 ,  G01N33/50 ,  C09K11/06 ,  C07F7/08

Abstract: The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.

公开(公告)号：US20230390319A1

公开(公告)日：2023-12-07

申请号：US18250002

申请日：2021-10-22

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eunha KIM ,  Sanghee LEE ,  Sang-Kee CHOI ,  Hyungi KIM ,  Hee Ra JUNG

IPC: A61K31/7084 ,  A61K31/444 ,  A61K31/437 ,  A61P35/00 ,  A61P37/04

CPC classification number: A61K31/7084 ,  A61K31/444 ,  A61K31/437 ,  A61P35/00 ,  A61P37/04

Abstract: The present invention relates to an interferon gene stimulator composition containing an indolizine derivative as an active ingredient. The composition may overcome the problem of low disease control rate, unlike the use of a cyclic-di-nucleotide alone. Specifically, since the composition contains the cyclic-di-nucleotide together with the compound of Formula 1, it may exhibit high activity even when a low concentration of the cyclic-di-nucleotide is used.

公开(公告)号：US20210214372A1

公开(公告)日：2021-07-15

申请号：US17057967

申请日：2019-05-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sangdon CHOI ,  Eunha KIM

IPC: C07D498/04 ,  C07D213/72 ,  C07D401/04

Abstract: A small molecule antagonist compound having a toll-like receptor 3/7/8/9 inhibitory function and its use in inhibiting TLR7, TLR8, TLR9 and TLR3 are disclosed. A novel compound expressed by TAC5 and TAC5-a, TAC5-c, TAC5-d or TAC5-e which are derivatives thereof not only prevents TNFα secretion, NFkB activation, IkB degradation and MAPKs phosphorylation induced by poly(I:C) (TLR3 agonist), IMQ (TLR7 agonist), CL075 (TLR7/8 agonist), R848 (TLR7/8 agonist), TL8 (TLR8 agonist) or CpG ODN (TLR9 agonist), but also inhibits generation of inflammatory cytokine, and thus is highly advantageous for preventive or therapeutic use for TLR3/7/8/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus, psoriasis and the like.