公开(公告)号：US20200340920A1

公开(公告)日：2020-10-29

申请号：US16860540

申请日：2020-04-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Eunha KIM ,  Wook Kim ,  Jong Hyun Kim ,  June Sung ,  Jun Gi RHO

IPC: G01N21/64 ,  G01N33/50 ,  C09K11/06 ,  C07F7/08

Abstract: The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.

公开(公告)号：US20190231898A1

公开(公告)日：2019-08-01

申请号：US16340897

申请日：2017-09-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Wook KIM ,  Hwa Seung HAN ,  Jae Hyung PARK ,  Jun Gi RHO ,  Juhwan YOON

IPC: A61K47/69 ,  A61P3/04 ,  A61P3/10 ,  A61P29/00 ,  A61P19/02 ,  A61K31/728 ,  A61K47/59 ,  A61K47/54 ,  A61K9/00 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease, which includes hyaluronic acid nanoparticles, and more particularly, to a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease, which includes hyaluronic acid nanoparticles formed in such a way that 5β-cholanic acid or polycaprolactone binds to a hydrophobic moiety of hyaluronic acid through self-assembly in an aqueous solution state. The pharmaceutical composition for preventing or treating an inflammatory disease or a metabolic disease, which includes hyaluronic acid nanoparticles, according to the present invention reduces body weight, lowers food intake, has an effect of reducing blood glucose as a result of a glucose tolerance test (GTT), and has an effect of reducing insulin resistance, inflammatory inducers (NF-κB, IL-1β, CD44, TNF-α, NLRP3 inflammasome, and the like), and macrophage tissue infiltration, and thus may be effectively used as a pharmaceutical composition for preventing or treating inflammatory diseases or metabolic diseases.