公开(公告)号：US20190231898A1

公开(公告)日：2019-08-01

申请号：US16340897

申请日：2017-09-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Wook KIM ,  Hwa Seung HAN ,  Jae Hyung PARK ,  Jun Gi RHO ,  Juhwan YOON

IPC: A61K47/69 ,  A61P3/04 ,  A61P3/10 ,  A61P29/00 ,  A61P19/02 ,  A61K31/728 ,  A61K47/59 ,  A61K47/54 ,  A61K9/00 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease, which includes hyaluronic acid nanoparticles, and more particularly, to a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease, which includes hyaluronic acid nanoparticles formed in such a way that 5β-cholanic acid or polycaprolactone binds to a hydrophobic moiety of hyaluronic acid through self-assembly in an aqueous solution state. The pharmaceutical composition for preventing or treating an inflammatory disease or a metabolic disease, which includes hyaluronic acid nanoparticles, according to the present invention reduces body weight, lowers food intake, has an effect of reducing blood glucose as a result of a glucose tolerance test (GTT), and has an effect of reducing insulin resistance, inflammatory inducers (NF-κB, IL-1β, CD44, TNF-α, NLRP3 inflammasome, and the like), and macrophage tissue infiltration, and thus may be effectively used as a pharmaceutical composition for preventing or treating inflammatory diseases or metabolic diseases.