公开(公告)号：US11629155B2

公开(公告)日：2023-04-18

申请号：US17057967

申请日：2019-05-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sangdon Choi ,  Eunha Kim

IPC: C07D498/04 ,  C07D213/72 ,  C07D401/04

Abstract: A small molecule antagonist compound having a toll-like receptor 3/7/8/9 inhibitory function and its use in inhibiting TLR7, TLR8, TLR9 and TLR3 are disclosed. A novel compound expressed by TAC5 and TAC5-a, TAC5-c, TAC5-d or TAC5-e which are derivatives thereof not only prevents TNFα secretion, NFkB activation, IkB degradation and MAPKs phosphorylation induced by poly(I:C) (TLR3 agonist), IMQ (TLR7 agonist), CL075 (TLR7/8 agonist), R848 (TLR7/8 agonist), TL8 (TLR8 agonist) or CpG ODN (TLR9 agonist), but also inhibits generation of inflammatory cytokine, and thus is highly advantageous for preventive or therapeutic use for TLR3/7/8/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus, psoriasis and the like.

公开(公告)号：US20250051290A1

公开(公告)日：2025-02-13

申请号：US18723115

申请日：2022-12-26

Applicant: Ajou University Industry-Academic Cooperation Foundation ,  Sangmyung University Cheonan Council for Industry-Academic Cooperation Foundation

Inventor： Yi-Sook Jung ,  Eunha Kim ,  Sunghou Lee ,  Hye Jin Jee ,  Ju-Young Park

IPC: C07D239/95 ,  A61K31/517 ,  A61P25/20 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a novel compound which can provide a sleep improving effect or the use thereof. Some compounds have an adenosine receptor agonistic activity. The novel compound of the present invention can shorten sleep latency and extend total sleep duration, and thus may be effectively used for a pharmaceutical composition for preventing or treating a sleep disorder, a health functional food composition for preventing or relieving a sleep disorder, a composition for improving sleep, a sleep aid, or a method for treating a sleep disorder.

公开(公告)号：US11761894B2

公开(公告)日：2023-09-19

申请号：US16860540

申请日：2020-04-28

Applicant: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION

Inventor： Eunha Kim ,  Wook Kim ,  Jong Hyun Kim ,  June Sung ,  Jun Gi Rho

IPC: C07F7/08 ,  G01N21/64 ,  G01N33/50 ,  C09K11/06

CPC classification number: G01N21/6428 ,  C07F7/0816 ,  C09K11/06 ,  G01N21/6458 ,  G01N33/5014 ,  C09K2211/1007 ,  C09K2211/1018 ,  G01N2021/6439

Abstract: The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.