公开(公告)号：US20190136202A1

公开(公告)日：2019-05-09

申请号：US16242463

申请日：2019-01-08

申请人： AJINOMOTO CO., INC.,

发明人： Sho SENDA ,  Tomomi YOSHIDA ,  Satoru OKAMOTO ,  Yoko KURIYAMA ,  Manabu KITAZAWA ,  Ikue HARATA ,  Nao SUGIMOTO

IPC分类号： C12N5/074 ,  C12N5/0735 ,  C12N5/00

CPC分类号： C12N5/0696 ,  C12N5/0043 ,  C12N5/0606 ,  C12N2500/36 ,  C12N2500/46 ,  C12N2500/84 ,  C12N2533/90

摘要： Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a s pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.

公开(公告)号：US20180051250A1

公开(公告)日：2018-02-22

申请号：US15718574

申请日：2017-09-28

申请人： AJINOMOTO CO., INC.

发明人： Takuya MATSUMOTO ,  Sho SENDA ,  Tsuyoshi KOBAYASHI ,  Akihiro ARAKAWA

IPC分类号： C12N5/0797

CPC分类号： C12N5/0623 ,  A61K35/30 ,  A61L27/00 ,  C12N5/10 ,  C12N2500/24 ,  C12N2500/46 ,  C12N2501/115 ,  C12N2506/03 ,  C12N2506/45

摘要： Culture media, which contain chelated iron, promote cell proliferation of neural stem cells and/or neural progenitor cells while maintaining undifferentiated state and multipotency.

公开(公告)号：US20170198258A1

公开(公告)日：2017-07-13

申请号：US15435705

申请日：2017-02-17

申请人： AJINOMOTO CO., INC. ,  Kyoto University

发明人： Yonghui JIN ,  lkue HARATA ,  Sho SENDA ,  Hiroki OZAWA ,  Tsuyoshi KOBAYASHI ,  Junya TOGUCHIDA ,  Makoto IKEYA

IPC分类号： C12N5/0775 ,  A61K35/28

CPC分类号： C12N5/0663 ,  A61K35/28 ,  A61K35/55 ,  A61K35/56 ,  A61K2035/124 ,  C12N5/00 ,  C12N2500/32 ,  C12N2500/84

摘要： Mesenchymal stem cells may be culture for a long period, without using any special apparatus, equipment and the like, in a medium in which seven kinds of nonessential amino acids of glycine, alanine, serine, proline, asparagine, aspartic acid, and glutamic acid are reduced.

公开(公告)号：US20150011003A1

公开(公告)日：2015-01-08

申请号：US14497926

申请日：2014-09-26

申请人： AJINOMOTO CO., INC.

发明人： Yoko KURIYAMA ,  Nao SUGIMOTO ,  Manabu KITAZAWA ,  Satoru OKAMOTO ,  Sho SENDA ,  Ikue HARATA ,  Satoru OHASHI

IPC分类号： C12N5/0775 ,  C08G63/91 ,  C08G65/48 ,  C12N5/074

CPC分类号： C12N5/0663 ,  C08G63/912 ,  C08G65/48 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2501/115

摘要： A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.

摘要翻译： 包含成纤维细胞生长因子（FGF）的培养基和在FGF存在下促进干细胞生长的浓度的硫酸化合物或其药学上可接受的盐可用于培养干细胞。

公开(公告)号：US20200370006A1

公开(公告)日：2020-11-26

申请号：US16898844

申请日：2020-06-11

申请人： AJINOMOTO CO., INC.

发明人： Yoko KURIYAMA ,  Sho SENDA ,  Yumi ANDO ,  Tomomi YOSHIDA ,  Haruna SATO ,  Daisuke EJIMA ,  Takayoshi FUJII ,  Masayo DATE ,  Manabu KITAZAWA

IPC分类号： C12N5/071 ,  C12N5/00 ,  C12N5/074

摘要： Culture media, which contain albumin carrying a reduced amount of fatty acid, are useful for culturing stem cells.

公开(公告)号：US20190024047A1

公开(公告)日：2019-01-24

申请号：US16144187

申请日：2018-09-27

申请人： AJINOMOTO CO., INC.

发明人： Takuya MATSUMOTO ,  Ikue HARATA ,  Sho SENDA

IPC分类号： C12N5/0793 ,  C12N5/0797

摘要： Media which are substantially free of one or more amino acids selected from the group consisting of L-glutamine, L-asparagine, and L-aspartic acid are useful for producing a neural stem cell and/or a neural progenitor cell with promoted neuronal differentiation potency.

公开(公告)号：US20180016554A1

公开(公告)日：2018-01-18

申请号：US15718445

申请日：2017-09-28

申请人： AJINOMOTO CO., INC.

发明人： Takuya MATSUMOTO ,  Sho SENDA ,  Tsuyoshi KOBAYASHI

IPC分类号： C12N5/0797

CPC分类号： C12N5/0623 ,  C12N2500/36 ,  C12N2500/50 ,  C12N2500/90 ,  C12N2501/115

摘要： A medium, which contains human serum albumin, is useful for proliferating neural stem cells and/or neural progenitor cells.

公开(公告)号：US20150329832A1

公开(公告)日：2015-11-19

申请号：US14813374

申请日：2015-07-30

申请人： AJINOMOTO CO., INC.,

发明人： Sho SENDA ,  Tomomi YOSHIDA ,  Satoru OKAMOTO ,  Yoko KURIYAMA ,  Manabu KITAZAWA ,  lkue HARADA ,  Nao SUGIMOTO

IPC分类号： C12N5/074

摘要： Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.

摘要翻译： 在包含至少一种选自乙醇胺，乙醇胺类似物和其药学上可接受的盐的培养基中培养多能干细胞，其基本上不含β-巯基乙醇或含有β-巯基乙醇 不超过9μM的浓度等对多能干细胞的增殖有效，同时保持未分化状态。