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公开(公告)号：US09744196B2
公开(公告)日：2017-08-29
申请号：US14694290
申请日：2015-04-23
IPC分类号： A61K35/64 , A61K35/56 , A61K35/62 , A61K35/612 , A61K35/618 , C12P21/06
CPC分类号： A61K35/62 , A61K35/56 , A61K35/612 , A61K35/618 , C12P21/06
摘要： The present invention relates to a field of veterinary and human medicine. In particular, the invention relates to a composition suitable for parenteral administration, based on hydrolyzate obtained from natural bioresources, a composition for use in treating and/or preventing a pathological condition in a mammal in need thereof, and various other uses thereof. More particularly the invention relates to a composition having immunomodulatory properties being based on a hydrolyzate obtained from bioresources, which composition is used for parenteral administration to a mammal in need thereof.
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2.发明申请PORIFERA-BASED THERAPEUTIC COMPOSITIONS FOR TREATING AND PREVENTING SKIN DISEASES 审中-公开用于治疗和预防皮肤疾病的基于PORIFERA的治疗组合物公开(公告)号：US20150079624A1
公开(公告)日：2015-03-19
申请号：US14553694
申请日：2014-11-25
申请人： Maria Villani
发明人： Maria Villani
CPC分类号： A61K35/56 , A61K9/14 , A61K33/22 , A61K33/40 , A61K35/655 , A61K36/02 , A61K36/68 , B02C23/12 , G01N30/06 , G01N33/4833 , G01N33/5044 , A61K2300/00 , A61K31/40
摘要： Methods and protocols of harvesting and processing of Porifera species, specifically sponges, and more specifically fresh water species of Genus Spongilla; testing and storing of the processed Spongilla powder; and manufacturing and packaging of Spongilla-based therapeutic compositions for treating and preventing skin diseases are disclosed. Treatable skin conditions and diseases include without limitation acne vulgaris, rosacea, seborrheic dermatitis, psoriasis, photo-aging and actinic keratosis, acne vulgaris, psoriasis, photo-aging, wounds, scars, and eczema (atopic dermatitis).
摘要翻译： Porifera种类，特别是海绵，特别是海绵属的淡水种的收获和加工方法和方案; 测试和储存加工的海绵粉; 公开了用于治疗和预防皮肤疾病的基于海绵的治疗组合物的制造和包装。 可治疗的皮肤病症和疾病包括但不限于寻常痤疮，红斑痤疮，脂溢性皮炎，牛皮癣，光老化和光化性角化病，寻常痤疮，牛皮癣，光老化，伤口，疤痕和湿疹（特应性皮炎）。
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公开(公告)号：US20130156860A1
公开(公告)日：2013-06-20
申请号：US13768790
申请日：2013-02-15
申请人： Fabien De Meester
发明人： Fabien De Meester
CPC分类号： A61K35/12 , A23K20/158 , A23K50/75 , A23L33/12 , A23V2002/00 , A61K31/232 , A61K35/20 , A61K35/56 , A61K35/60 , A61K36/00 , A23V2200/328 , A23V2200/326 , A23V2200/308 , A23V2250/1882 , A23V2250/1874
摘要： The present invention is related to a method for the prevention and possibly the treatment of chronic diseases, preferably inflammatory associated chronic diseases that may affect an animal including a human, by the administration of a sufficient amount of a (functional) food or feed to the diet of this animal.
摘要翻译： 本发明涉及通过将足量的（功能性）食物或饲料施用于预防和可能地治疗慢性疾病，优选可能影响包括人的动物的炎性相关慢性疾病的方法。 这种动物的饮食。
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公开(公告)号：US20100330192A1
公开(公告)日：2010-12-30
申请号：US12449686
申请日：2008-02-25
申请人： Fabien De Meester
发明人： Fabien De Meester
CPC分类号： A61K35/12 , A23K20/158 , A23K50/75 , A23L33/12 , A23V2002/00 , A61K31/232 , A61K35/20 , A61K35/56 , A61K35/60 , A61K36/00 , A23V2200/328 , A23V2200/326 , A23V2200/308 , A23V2250/1882 , A23V2250/1874
摘要： The present invention is related to a method for the prevention and possibly the treatment of chronic diseases, preferably inflammatory associated chronic diseases that may affect an animal including a human, by the administration of a sufficient amount of a (functional) food or feed to the diet of this animal.
摘要翻译： 本发明涉及通过将足量的（功能性）食物或饲料施用于预防和可能地治疗慢性疾病，优选可能影响包括人的动物的炎性相关慢性疾病的方法。 这种动物的饮食。
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6.发明申请公开(公告)号：US20180000787A1
公开(公告)日：2018-01-04
申请号：US15520801
申请日：2015-10-23
IPC分类号： A61K31/4168 , A61K31/4015 , C07D233/88 , C07D207/327 , G01N30/02 , A61K35/56
CPC分类号： A61K31/4168 , A61K31/4015 , A61K35/56 , C07D207/327 , C07D233/88 , C12N2740/16063 , G01N33/5008 , G01N2030/027
摘要： Anti-viral compounds with low cytotoxicity are identified from screening of products found in Red Sea sponges, including the sponge Stylissa carteri. The identified compounds can be brominated pyrrole-2-aminoimidazole alkaloids and derivatives thereof. Specific examples of identified compounds include oroidin, hymenialdisine, and debromohymenialdisine, as well as derivatives thereof. The compounds also can be useful scaffolds or pharmacores for further chemical modification and derivatization. Selected compounds, particularly oroidin, show selective anti-viral HIV-1 activity coupled with reduced cytotoxicity. The compounds can function as HIV reverse-transcriptase inhibitors, and molecular modeling can be used to confirm inhibition.
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7.发明申请USE OF EGG YOLK OIL AND THE BENZOPYRENE-ELIMINATED EGG YOLK OIL IN THE TREATMENT OF ALLERGIC RHINITIS 审中-公开EGG YOLK油和苯并噻吩类EGG羊油在过敏性RHINITIS治疗中的应用公开(公告)号：US20160367604A1
公开(公告)日：2016-12-22
申请号：US15143850
申请日：2016-05-02
发明人： De-Li DONG
CPC分类号： A61K35/56 , A61K9/0043 , A61K35/57
摘要： The application of egg yolk oil, as well as benzopyrene-eliminated egg yolk oil, is prepared for medicaments for the treatment of allergic rhinitis. By topical application of egg yolk oil in the nasal cavity, symptoms of allergic rhinitis could be improved significantly. After topical treatment with egg yolk oil, levels of inflammatory cytokines IL-4 and IgE antibodies in lymphocytes of model mice with allergic rhinitis may be reduced. The method discloses a new application of egg yolk oil for the treatment of allergic rhinitis. In order to avoid the presence of residual benzopyrene (which is potentially carcinogenic) in egg yolk oil extracted by heating yolk, the method prepares a medicament for treating allergic rhinitis with benzopyrene-eliminated egg yolk oil, thereby avoiding the potential carcinogenic risk of benzopyrene residue.
摘要翻译： 制备用于治疗过敏性鼻炎的药物的蛋黄油以及苯并芘消除的蛋黄油的应用。 通过在鼻腔局部施用蛋黄油，可以显着改善过敏性鼻炎的症状。 在用蛋黄油局部处理后，可能会减少具有过敏性鼻炎的模型小鼠的淋巴细胞中炎性细胞因子IL-4和IgE抗体的水平。 该方法公开了用于治疗过敏性鼻炎的蛋黄油的新应用。 为了避免通过加热蛋黄提取的蛋黄油中存在残留的苯并芘（可能是致癌物质），该方法制备用苯并芘消除的蛋黄油治疗过敏性鼻炎的药物，从而避免了苯并芘残留的潜在致癌风险 。
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