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公开(公告)号：US20220228306A1
公开(公告)日：2022-07-21
申请号：US17595549
申请日：2020-06-12
发明人： Petra L. Kohler Reidi , Saurabh Batra , Hannah C. Cohen , Semra Colak Atan , Naimul Karim , Joseph J. Stoffel , Joseph A. Dunbar , Colby W. Dotseth
IPC分类号： D04H1/56 , D04H1/4291 , D04H1/4309 , D04H1/4258 , D01F6/34 , D01F8/10
摘要： A method of making a nonwoven fiber web comprises: providing a melt-blown nonwoven fiber web comprising bonded primary fibers having an average fiber diameter of 2 to 100 microns, wherein the primary fibers comprise a copolymer comprising divalent hydroxyethylene monomer units and divalent dihydroxybutylene monomer units; opening at least a portion of the melt-blown nonwoven fiber web to provide loose primary fibers; combining the loose primary fibers with secondary fibers; and forming a secondary nonwoven fiber web comprising the primary fibers and secondary fibers. A fiber web preparable according to the method and a multicomponent fiber including a first phase comprising a copolymer comprising divalent hydroxyethylene monomer units and divalent dihydroxybutylene monomer units and a second phase comprising a non-biodegradable polymer.
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公开(公告)号：US20200330347A1
公开(公告)日：2020-10-22
申请号：US16955224
申请日：2018-12-18
发明人： Katie F. Wlaschin , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. Oxman , Jie Yang
IPC分类号： A61K8/36 , A61K8/92 , A61K8/73 , A61K8/9794 , A61K8/42 , A61K8/67 , A61K8/49 , A61K8/365 , A61Q11/00
摘要： Compositions that include: from 5 wt-% to 70 wt-% of one or more plant based oils based on the total weight of the composition; from 35 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; not greater than 7.5 wt-% of one or more surfactants based on the total weight of the composition; and not greater than 3 wt-% of a viscosity modifier of, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.
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公开(公告)号：US20230346954A1
公开(公告)日：2023-11-02
申请号：US18002122
申请日：2021-06-10
IPC分类号： A61K47/55 , C07D471/04
CPC分类号： A61K47/55 , C07D471/04
摘要： Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
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公开(公告)号：US10941252B2
公开(公告)日：2021-03-09
申请号：US16345809
申请日：2017-10-23
发明人： Hannah C. Cohen , Amanda C. Engler , Ranjani V. Parthasarathy , Haoming Rong , Ramesh C. Kumar , Matthew T. Scholz , James P. Dizio , Audrey A. Sherman , Richard G. Hansen , Douglas A. Hanggi , Dale J. Case , David Duane Johnson
IPC分类号： C08G77/46 , C08G77/458 , C08K5/00 , C08G64/18
摘要： A copolymer composition that includes a silicone copolymer, methods of making the composition, and articles that include the composition, wherein the copolymer composition includes a silicone copolymer having a backbone composition that includes: silicone segments in an amount of 5 wt-% to 40 wt-%, based on the total weight of the silicone copolymer; hydrophilic segments in an amount of 40 wt-% to 75 wt-%, based on the total weight of the silicone copolymer; and reinforcing segments in an amount of 5 wt-% to 30 wt-%, based on the total weight of the silicone copolymer, wherein the reinforcing segments are derived from the reaction of one or more chain extenders with one or more multi-functional isocyanates, multi-functional carboxylic acids, multi-functional anhydrides, multi-functional esters, and/or multi-functional acid halides; wherein the silicone segments, hydrophilic segments, and reinforcing segments are connected through urea, urethane, amide, and/or oxamide linkages; wherein the hydrophilic segments and the reinforcing segments are present in a weight ratio of 1.8:1 to 8:1; and the hydrophilic segments and the silicone segments are present in a weight ratio of 1.3:1 to 4.5:1.
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![N-1 BRANCHED CYCLOALKYL SUBSTITUTED IMIDAZO[4,5-c]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS](/abs-image/US/2024/05/02/US20240140946A1/abs.jpg.150x150.jpg)
5.发明公开公开(公告)号：US20240140946A1
公开(公告)日：2024-05-02
申请号：US18404478
申请日：2024-01-04
IPC分类号： C07D471/04 , A61K31/4745 , A61P37/02
CPC分类号： C07D471/04 , A61K31/4745 , A61P37/02
摘要： Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号：US20230357500A1
公开(公告)日：2023-11-09
申请号：US18004910
申请日：2021-06-14
发明人： Carl A. Laskowski , Timothy M. Gillard , Ranjani V. Parthasarathy , Hannah C. Cohen , Max A. Kruziki
IPC分类号： C08G65/327 , C08G65/08 , C08G81/00 , A61K31/80
CPC分类号： C08G65/327 , C08G65/08 , C08G81/00 , A61K31/80 , C08G2650/58
摘要： Phosphate-containing copolymers, medical compositions containing the phosphate-containing copolymers, and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. The phosphate-containing copolymers are prepared by phosphorylating either a random copolymer or a random copolymeric block that contains monomeric units of propylene oxide and glycidol.
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公开(公告)号：US11779446B2
公开(公告)日：2023-10-10
申请号：US16196872
申请日：2018-11-20
发明人： Katie F. Wlaschin , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. Oxman , Jie Yang , Richard P. Rusin
IPC分类号： A61C19/06 , A61P1/02 , A61K36/00 , A61Q11/00 , A61K9/12 , A61K8/25 , A61K8/41 , A61K8/73 , A61K8/92 , A61K47/12 , A61K9/107 , A61K47/26 , A61K8/81 , A61K8/06 , A61K9/00 , A61K47/10 , A61K8/37 , A61K36/185 , A61K47/36 , A61K47/44 , A61K36/28 , A61K36/63 , A61K31/025 , A61K31/075 , A61K31/164 , A61K31/198 , A61K31/205 , A61K31/355 , A61K31/714 , A61K31/728 , A61K36/48 , A61K36/52 , A61K36/736 , A61K36/752 , A61K36/81
CPC分类号： A61C19/063 , A61K8/062 , A61K8/25 , A61K8/375 , A61K8/41 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/737 , A61K8/8147 , A61K8/8176 , A61K8/922 , A61K9/006 , A61K9/0053 , A61K9/107 , A61K9/12 , A61K31/025 , A61K31/075 , A61K31/164 , A61K31/198 , A61K31/205 , A61K31/355 , A61K31/714 , A61K31/728 , A61K36/00 , A61K36/185 , A61K36/28 , A61K36/48 , A61K36/52 , A61K36/63 , A61K36/736 , A61K36/752 , A61K36/81 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/36 , A61K47/44 , A61P1/02 , A61Q11/00
摘要： Compositions that include: from 5 wt-% to 30 wt-% of one or more plant based oils based on the total weight of the composition; from 70 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; from 0.1 wt-% to 5 wt-% of one or more surfactants based on the total weight of the composition; and from 0.05 wt-% to 3 wt-% of a viscosity modifier, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.
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公开(公告)号：US20230302045A1
公开(公告)日：2023-09-28
申请号：US18004940
申请日：2021-06-14
发明人： Semra Colak Atan , Hannah C. Cohen , Max A. Kruziki , Ranjani V. Parthasarathy , Matthew T. Scholz
摘要： Medical compositions and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. More specifically, the medical compositions include a phosphonate-containing polymer. The phosphonate-containing polymers can suppress the expression of various virulence factors without destroying all microbes that may be present.
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公开(公告)号：US20220249340A1
公开(公告)日：2022-08-11
申请号：US17724019
申请日：2022-04-19
发明人： Katie F. WLASCHIN , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. OXMAN , Jie Yang
IPC分类号： A61K8/36 , A61K8/9794 , A61K8/365 , A61K8/42 , A61K8/49 , A61K8/67 , A61K8/73 , A61K8/92 , A61Q11/00
摘要： Compositions that include: from 5 wt-% to 70 wt-% of one or more plant based oils based on the total weight of the composition; from 35 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; not greater than 7.5 wt-% of one or more surfactants based on the total weight of the composition; and not greater than 3 wt-% of a viscosity modifier of, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.
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![PHENETHYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS WITH AN N-1 BRANCHED GROUP](/abs-image/US/2022/06/23/US20220194935A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220194935A1
公开(公告)日：2022-06-23
申请号：US17594617
申请日：2020-06-03
IPC分类号： C07D471/04
摘要： Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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