公开(公告)号：US20130143200A1

公开(公告)日：2013-06-06

申请号：US13817828

申请日：2011-08-19

Applicant: Yu Sun ,  Zhe Lu ,  Clement Leung ,  Xuping Zhang

Inventor： Yu Sun ,  Zhe Lu ,  Clement Leung ,  Xuping Zhang

IPC: C12M3/00 ,  C12Q3/00 ,  C12Q1/24

CPC classification number: C12M23/12 ,  C12M21/06 ,  C12M23/22 ,  C12M23/28 ,  C12M23/34 ,  C12M41/48 ,  C12Q1/24 ,  C12Q3/00

Abstract: The present invention relates to systems and methods for automated, computer-controlled, tracking and manipulation of motile specimen. The systems and methods of the present invention are suited for tracking and manipulating sperm, particularly for Intracytoplasmic Sperm Injection (ICSI) procedures. The present invention also relates also to devices for holding motile cells, such as sperm, and non-motile cells, such as oocytes. The device of the present invention comprises a sealed chamber having an air outlet, one well for the motile cells, and another well for non-motile cells.

Abstract translation: 本发明涉及用于自动化，计算机控制，跟踪和操纵运动样品的系统和方法。 本发明的系统和方法适用于追踪和操纵精子，特别是精子内注射（ICSI）程序。 本发明还涉及用于保持诸如精子和诸如卵母细胞的非运动性细胞的运动细胞的装置。 本发明的装置包括具有空气出口的密封室，用于运动细胞的一个孔，以及用于非运动性细胞的另一孔。

公开(公告)号：US20130004477A1

公开(公告)日：2013-01-03

申请号：US13504286

申请日：2010-10-22

Applicant: Zhe Lu ,  Yanping Xu

Inventor： Zhe Lu ,  Yanping Xu

IPC: A61K31/26 ,  A61K38/44 ,  A61P29/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P1/18 ,  A61K33/18 ,  A61P11/08

CPC classification number: G01N33/84 ,  A23L33/10 ,  A61K8/23 ,  A61K31/26 ,  A61K31/275 ,  A61K38/44 ,  A61Q5/10 ,  A61Q19/08 ,  C12Y111/01007 ,  G01N2800/382 ,  A61K2300/00

Abstract: This invention provides compositions and methods for treating inflammation related diseases. Particularly, the present invention provides methods and compositions of administering thiocyanate to treat inflammation related diseases, such as cystic fibrosis, lung disease, lung cancer, asthma, bronchitis, pancreatic disease, digestive track disease, diabetes, neurological disorder, cardio-vascular disease, atherosclerosis, arthritis, nephritis, or stroke, and neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, or autism. The invention provides the use of thiocyanate to diagnose inflammation related diseases.

Abstract translation: 本发明提供了治疗炎症相关疾病的组合物和方法。 特别地，本发明提供了硫氰酸盐治疗炎症相关疾病如囊性纤维化，肺部疾病，肺癌，哮喘，支气管炎，胰腺疾病，消化道疾病，糖尿病，神经障碍，心血管疾病， 动脉粥样硬化，关节炎，肾炎或中风，以及诸如阿尔茨海默病，帕金森病，多发性硬化或自闭症的神经障碍。 本发明提供了硫氰酸盐诊断炎症相关疾病的用途。

公开(公告)号：US09340762B2

公开(公告)日：2016-05-17

申请号：US13817828

申请日：2011-08-19

Applicant: Yu Sun ,  Zhe Lu ,  Clement Leung ,  Xuping Zhang

Inventor： Yu Sun ,  Zhe Lu ,  Clement Leung ,  Xuping Zhang

IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/24 ,  C12Q3/00 ,  C12M1/32 ,  C12M1/00 ,  C12M1/36

CPC classification number: C12M23/12 ,  C12M21/06 ,  C12M23/22 ,  C12M23/28 ,  C12M23/34 ,  C12M41/48 ,  C12Q1/24 ,  C12Q3/00

Abstract: The present invention relates to systems and methods for automated, computer-controlled, tracking and manipulation of motile specimen. The systems and methods of the present invention are suited for tracking and manipulating sperm, particularly for Intracytoplasmic Sperm Injection (ICSI) procedures. The present invention also relates also to devices for holding motile cells, such as sperm, and non-motile cells, such as oocytes. The device of the present invention comprises a sealed chamber having an air outlet, one well for the motile cells, and another well for non-motile cells.

Abstract translation: 本发明涉及用于自动化，计算机控制，跟踪和操纵运动样本的系统和方法。 本发明的系统和方法适用于追踪和操纵精子，特别是精子内注射（ICSI）程序。 本发明还涉及用于保持诸如精子和诸如卵母细胞的非运动性细胞的运动细胞的装置。 本发明的装置包括具有空气出口的密封室，用于运动细胞的一个孔，以及用于非运动性细胞的另一孔。

公开(公告)号：US06979572B1

公开(公告)日：2005-12-27

申请号：US09743054

申请日：1999-07-07

Applicant: Zhe Lu

Inventor： Zhe Lu

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/17 ,  C07K14/00 ,  C07K14/435 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/6872 ,  A61K38/00 ,  C07K14/43572 ,  G01N33/5041 ,  G01N2500/00 ,  G01N2800/042

Abstract: The present invention provides compounds and methods of identifying and designing compounds which inhibit activity of inward-rectifier K+ channels. In particular, compounds having a tertiapin-like α helix, such as a stable tertiapin derivative wherein the methionine residue in position 13 of tertiapin is replaced by glutamine, are described. Methods of using these compounds to control insulin secretion, and cardiac rhythm and electrical conduction, to modulate neurotransmissions of neurons, and to induce diuresis in mammals are also provided.

Abstract translation: 本发明提供鉴定和设计抑制内向整流通道的活性的化合物的化合物和方法。 特别地，描述了具有三节蛋白样α螺旋的化合物，例如其中三聚磷蛋白13位的甲硫氨酸残基被谷氨酰胺代替的稳定的三磷杂衍生物。 还提供了使用这些化合物来控制胰岛素分泌，心律和电传导以调节神经元的神经传递并诱导哺乳动物利尿的方法。