Abstract:
A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R1, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Abstract:
A plate vapor chamber array assembly with a plurality of plate vapor chambers joined in an array and each chamber having an evaporation area and an evacuated sealed chamber. The plate vapor chambers may be in direct contact with adjacent plate vapor chambers. A vapor chamber clamp surrounding the array has an inner surface engaging an outer edge of at least two of the plate vapor chambers of the array to press a surface of the plate vapor chamber array directly against the heat source.
Abstract:
A conjugate of a potent cytotoxic agent with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Abstract:
A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Abstract:
Disclosed is a leakage detection system (200) and a leakage detection method for detecting leakage in a gas supply system (10′) comprising a gas source (11; 12) connected to a gas delivery module (14) by a pipeline. The leakage detection system (200) comprises a flow meter (113) connectable along the pipeline remotely from an inlet of the gas delivery module (14); and a detection module (110) configured to receive signals representing a measured flow rate from the flow meter (113), and to compare the measured flow rate (115) to a stored leakage-free reference value (116) to detect an increase in flow rate in the presence of a leak. A flow resistance between the detection module (110) and an outlet of the gas delivery module (14) amplifies the increase in flow rate in the presence of a leak. The system (200) may comprise a flow rate elevation system (121) connectable between the gas source (11; 12) and the flow meter (113) for temporarily increasing the flow rate in the pipeline.
Abstract:
Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.
Abstract:
The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.
Abstract:
Techniques are described for exporting organizational charts being presented inside a browser window. The system can present an export canvas that identifies the portion of the organizational chart that is to be exported. In some embodiments, the export canvas can be automatically adjusted to prevent collisions with tiles within the organizational chart. In some examples, the export canvas can be presented on a different layer than the organizational chart, thus allowing the export canvas to move around freely without disrupting the underlying organizational chart.
Abstract:
An example controller for a power converter includes a feedback sampling circuit, drive logic and a false sampling prevention circuit. The feedback sampling circuit is coupled to sample a feedback signal received from a terminal of the controller and to generate a sample signal representative of a value of the feedback signal. The drive logic is coupled to the feedback sampling circuit and coupled to control the power switch to regulate an output of the power converter in response to the sample signal. The false sampling prevention circuit is coupled to receive a sampling complete signal that indicates when the sampling of the feedback signal is complete. The false sampling prevention circuit is further coupled to the drive logic to extend the off time of the power switch until the sampling complete signal indicates that the sampling of the feedback signal by the feedback sampling circuit is complete.
Abstract:
The flexible bearing of the wave generator for a wave gear device is a deep-groove ball bearing in which an outer race and an inner race form an annular flexible bearing ring capable of bending in a radial direction. A ball diameter Da is set to be 5 to 15% greater than that of each model of the currently available product. Dimensions of orbital plane radii ro, ri of the inner and outer races are set so that the ratio ro/Da of the orbital plane radius ro of the inner race and the ball diameter Da, as well as the ratio ri/Da of the orbital plane radius ri of the outer race and the ball diameter Da, are both in the range of 0.51 to 0.52. With this configuration, the service life of the flexible bearing can be extended.