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公开(公告)号：US08058037B2
公开(公告)日：2011-11-15
申请号：US12095244
申请日：2006-11-29
CPC分类号： C12P7/62 , C12N9/0006 , C12P7/42 , C12P17/06
摘要： The present invention provides a protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for proteins of the amino acid sequences as shown in SEQ ID NOS: 4 to 6), and a process for industrially advantageously producing a compound that inhibits HMG-CoA reductase and has an action to decrease serum cholesterol, using DNA encoding the protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for DNA encoding the protein comprising the amino acid sequence as shown in SEQ ID NO: 4).
摘要翻译： 本发明提供了包含SEQ ID NO：1〜3中任一项所示的氨基酸序列的蛋白质（除了SEQ ID NO：4〜6所示的氨基酸序列的蛋白质）和工业上的工序 有利地产生抑制HMG-CoA还原酶并具有降低血清胆固醇的作用的化合物，使用编码包含SEQ ID NO：1至3中任一项所示的氨基酸序列的蛋白的DNA（除了编码包含 如SEQ ID NO：4所示的氨基酸序列）。
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公开(公告)号：US07470528B2
公开(公告)日：2008-12-30
申请号：US11352308
申请日：2006-02-13
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译： 本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R1表示氢原子，取代或未取代的烷基或碱金属 并且R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。
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公开(公告)号：US07078204B2
公开(公告)日：2006-07-18
申请号：US10312007
申请日：2001-06-15
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/08 , C12Y101/01049
摘要： The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as “G6PD”) derived from a bacterium belonging to the genus Corynebacterium, a DNA encoding the enzyme, a recombinant DNA comprising the DNA, a transformant comprising the recombinant DNA, a transformant comprising the DNA on its chromosome, and a process for producing L-amino acid or G6PD which comprises culturing the transformant.According to the present invention, a modified G6PD and a DNA encoding the G6PD are obtained, and the productivity of L-amino acid by a microorganism can be improved by using the modified G6PD.
摘要翻译： 本发明涉及一种衍生自属于棒状杆菌属的细菌的新型葡萄糖-6-磷酸脱氢酶（以下称为“G6PD”），编码该酶的DNA，包含该DNA的重组DNA，包含重组体 DNA，包含其染色体上的DNA的转化体，以及生产L-氨基酸或G6PD的方法，其包括培养转化体。 根据本发明，获得了修饰的G6PD和编码G6PD的DNA，通过使用改良的G6PD可以提高微生物的L-氨基酸的生产率。
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公开(公告)号：US08703447B2
公开(公告)日：2014-04-22
申请号：US13520947
申请日：2011-01-07
CPC分类号： C12P13/14
摘要： Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.
摘要翻译： 提供了使用微生物生产L-谷氨酰胺或L-谷氨酸的有效方法。 通过在具有L-谷氨酰胺或L-谷氨酸生产能力的微生物培养基中培养L-谷氨酰胺或L-谷氨酸，其中形成超螺旋双链DNA的能力与 在培养基中产生和积累L-谷氨酰胺或L-谷氨酸，从培养基中回收L-谷氨酰胺或L-谷氨酸。
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公开(公告)号：US20100184163A1
公开(公告)日：2010-07-22
申请号：US12159156
申请日：2006-12-27
申请人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
摘要： A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacterium producing the polypeptide has L-glutamine productivity, a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism comprising the DNA or the recombinant DNA, and a process for producing L-glutamine using the microorganism are provided.
摘要翻译： 一种多肽，其包含氨基酸序列，其中一个或多个氨基酸被缺失，取代或添加在衍生自属于棒状杆菌型细菌的微生物的谷氨酰胺合成酶2的氨基酸序列中，其中产生多肽的棒状细菌具有L- 谷氨酰胺生产力，编码多肽的DNA，包含DNA的重组DNA，包含DNA或重组DNA的微生物，以及使用该微生物生产L-谷氨酰胺的方法。
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6.发明授权Amino acid racemase having low substrate specificity and process for producing racemic amino acid 有权具有低底物特异性的氨基酸消旋酶和用于生产外消旋氨基酸的方法公开(公告)号：US07247466B2
公开(公告)日：2007-07-24
申请号：US10506152
申请日：2003-02-28
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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公开(公告)号：US06893848B1
公开(公告)日：2005-05-17
申请号：US09958606
申请日：2000-04-14
申请人： Haruhiko Yokoi , Junko Ohnishi , Keiko Ochiai , Yoshiyuki Yonetani , Akio Ozaki
发明人： Haruhiko Yokoi , Junko Ohnishi , Keiko Ochiai , Yoshiyuki Yonetani , Akio Ozaki
CPC分类号： C12N9/1217 , C12P13/08
摘要： The present invention relates to a novel aspartokinase derived from a Coryneform bacterium; a DNA encoding the enzyme; a recombinant DNA containing the above DNA; a Coryneform bacterium having the above recombinant DNA or a Coryneform bacterium having the DNA on its chromosome; and a process for producing L-lysine by culturing the above microorganism. Construction has been successfully made of a DNA encoding an aspartokinase freed from concerted feedback inhibition by L-lysine and L-threonine derived from a Corynebacterium and has a nucleotide sequence encoding an amino acid sequence wherein the amino acid residue at position 311 is an amino acid other than Thr in the amino acid sequence shown by SEQ ID NO: 18.
摘要翻译： 本发明涉及一种衍生自棒状杆菌属细菌的新型天冬氨酸激酶; 编码酶的DNA; 含有上述DNA的重组DNA; 具有上述重组DNA的棒状细菌或其染色体上具有DNA的棒状细菌; 以及通过培养上述微生物来生产L-赖氨酸的方法。 已经成功制备了编码天冬氨酸的DNA，其不含由L-赖氨酸和由棒状杆菌衍生的L-苏氨酸的协同反馈抑制，并且具有编码氨基酸序列的核苷酸序列，其中311位的氨基酸残基是氨基酸 SEQ ID NO：18所示的氨基酸序列中的Thr除外。
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公开(公告)号：US08673590B2
公开(公告)日：2014-03-18
申请号：US12594903
申请日：2008-04-04
IPC分类号： C07K5/06 , C07K14/195 , C12P21/02
CPC分类号： C07K14/195 , C07K5/06026 , C12P21/02
摘要： The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to theoutside of the microbial cell is higher than that of a parental strain.
摘要翻译： 本发明提供了具有产生具有二肽合成活性的蛋白质的能力的微生物，其中将微生物细胞中的二肽转运到微生物细胞外侧的蛋白质的活性高于亲本菌株的活性。
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公开(公告)号：US08647839B2
公开(公告)日：2014-02-11
申请号：US12594928
申请日：2008-04-04
IPC分类号： C12P21/06
CPC分类号： C07K14/195 , C12P13/005 , C12P21/02
摘要： The invention provides a process for producing glutathione or γ-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or γ-glutamylcysteine biosynthesis, compared with that of the parent strain, forming and accumulating glutathione or γ-glutamylcysteine in the medium, and recovering the glutathione or γ-glutamylcysteine from the culture.
摘要翻译： 本发明提供了一种通过在培养基中培养具有将细胞内谷胱甘肽转运至细胞外的活性较高的蛋白质的活性的培养基和与谷胱甘肽或谷氨酰半胱氨酸相关的蛋白质的较高活性来生产谷胱甘肽或γ-谷氨酰半胱氨酸的方法 与亲本菌株相比，在培养基中形成和积累谷胱甘肽或γ-谷氨酰半胱氨酸，从培养物中回收谷胱甘肽或γ-谷氨酰半胱氨酸。
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公开(公告)号：US20120322115A1
公开(公告)日：2012-12-20
申请号：US13520947
申请日：2011-01-07
IPC分类号： C12P13/14
CPC分类号： C12P13/14
摘要： Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.
摘要翻译： 提供使用微生物生产L-谷氨酰胺或L-谷氨酸的有效方法。 通过在具有L-谷氨酰胺或L-谷氨酸生产能力的微生物培养基中培养L-谷氨酰胺或L-谷氨酸，其中形成超螺旋双链DNA的能力与 在培养基中产生和积累L-谷氨酰胺或L-谷氨酸，从培养基中回收L-谷氨酰胺或L-谷氨酸。
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