公开(公告)号：US20220259188A1

公开(公告)日：2022-08-18

申请号：US17614732

申请日：2020-06-01

申请人： Hua ZHOU ,  John J. ACTON, III ,  Michael J. ARDOLINO ,  Yi-Heng CHEN ,  Peter H. FULLER ,  Anmol GULATI ,  Rebecca Elizabeth JOHNSON ,  William P. KAPLAN ,  Solomon D. KATTAR ,  Mitchell H. KEYLOR ,  Derun LI ,  Kaitlyn Marie LOGAN ,  Min LU ,  Gregori J. MORRIELLO ,  Santhosh F. NEELAMKAVIL ,  Barbara PIO ,  Nunzio SCIAMMETTA ,  Vladimir SIMOV ,  Jing SU ,  Luis TORRES ,  Xin YAN ,  Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  John J. Acton, III ,  Michael J. Ardolino ,  Yi-Heng Chen ,  Peter H. Fuller ,  Anmol Gulati ,  Rebecca Elizabeth Johnson ,  William P. Kaplan ,  Solomon D. Kattar ,  Mitchell H. Keylor ,  Derun Li ,  Kaitlyn Marie Logan ,  Min Lu ,  Gregori J. Morriello ,  Santhosh F. Neelamkavil ,  Barbara Pio ,  Nunzio Sciammetta ,  Vladimir Simov ,  Jing Su ,  Luis Torres ,  Xin Yan

IPC分类号： C07D405/14 ,  C07D487/08 ,  C07D409/14 ,  C07D403/04 ,  C07D403/14 ,  C07D498/04 ,  C07D498/08 ,  C07D487/10 ,  C07D401/14 ,  C07D471/10 ,  C07D491/107 ,  C07D471/04 ,  C07D487/04 ,  A61P25/16

摘要： The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

公开(公告)号：US20120304432A1

公开(公告)日：2012-12-06

申请号：US13327441

申请日：2011-12-15

申请人： XIN-YAN WANG ,  GUANG-JUN QIN

发明人： XIN-YAN WANG ,  GUANG-JUN QIN

IPC分类号： B25B27/14

CPC分类号： G06F1/1626 ,  G06F1/18 ,  Y10T29/5397

摘要： A touch screen mounting mechanism for mounting a touch screen on a housing includes a base, a mounting board fixed on the base, a push element slidably mounted on the base along the vertical direction of the base, drive members fixed on the mounting board and positioning elements slidably mounted on the surface of the mounting board and located around a positioning slot. The mounting board defines a positioning slot for retaining the touch screen and the housing, the push element defines driving wedge walls, the drive members are used to drive the push element to slide, each positioning element defines a following wedge wall resisting on one driving wedge wall, and in mounting, the following wedge walls are pushed by the driving wedge walls to slide towards the center of the positioning slot to position the touch screen and the housing in the correct order.

摘要翻译： 用于将触摸屏安装在壳体上的触摸屏安装机构包括基座，固定在基座上的安装板，沿着基座的垂直方向可滑动地安装在基座上的推动元件，固定在安装板上的驱动构件和定位 元件可滑动地安装在安装板的表面上并且位于定位槽周围。 安装板限定用于保持触摸屏和壳体的定位槽，推动元件限定驱动楔形壁，驱动构件用于驱动推动元件滑动，每个定位元件限定在一个驱动楔上抵抗的后续楔形壁 壁，并且在安装时，以下楔形壁被驱动楔形壁推动以朝向定位槽的中心滑动，以便以正确的顺序定位触摸屏和壳体。

公开(公告)号：US20110131512A1

公开(公告)日：2011-06-02

申请号：US12629061

申请日：2009-12-02

申请人： Xin Yan ,  Joseph S. Binder ,  Malik Bilal Waheed ,  Sudhanshu Kulkarni

发明人： Xin Yan ,  Joseph S. Binder ,  Malik Bilal Waheed ,  Sudhanshu Kulkarni

IPC分类号： G06F3/048

CPC分类号： G06F9/451

摘要： An application can be run and initial user interface definitions for the application can be loaded into memory. The application can use the initial user interface definitions in the memory to present an initial user interface for the application. In response to user input, one or more updates can be made to the initial user interface definitions in the memory, and the application can use the updated user interface definitions to present an updated user interface for the application. Presenting the initial user interface, making the updates, and using the updated definitions to present the updated user interface can be done while the application continues to run.

摘要翻译： 可以运行应用程序，并将应用程序的初始用户界面定义加载到内存中。 应用程序可以使用内存中的初始用户界面定义来呈现应用程序的初始用户界面。 响应于用户输入，可以对存储器中的初始用户界面定义进行一个或多个更新，并且应用可以使用更新的用户界面定义来呈现应用的更新的用户界面。 可以在应用程序继续运行时，呈现初始用户界面，进行更新以及使用更新的定义来呈现更新的用户界面。

公开(公告)号：US07757207B2

公开(公告)日：2010-07-13

申请号：US10922580

申请日：2004-08-20

申请人： Xin Yan ,  Keira L. Amos

发明人： Xin Yan ,  Keira L. Amos

IPC分类号： G06F9/44 ,  G06F3/00 ,  G06F3/048 ,  G06F9/45 ,  G06G7/62

CPC分类号： G06F8/34 ,  G06F9/451

摘要： A WYSIWYG visual programming environment for programming applications for portable computer devices is provided. The developer selects a form skin based on the underlying portable computer device that the developer intends the application to execute on. The form skin appears to the developer as a graphic modeled after the actual device. The developer is able to drag and drop GUI elements onto the form, where they appear at approximately the same size and resolution as they would to the user of the actual device, regardless of the resolution used on the developer's computing device. The developer is able to associate code with the GUI elements, as well as any softkeys that appear on the form skin. The developer is able to test the application by emulating the hardware of the portable device, and operating the device using the form skin. Through the form skin, the developer is able to see nearly exactly how the application will look and operate on the underlying portable device without having to leave the development environment.

摘要翻译： 提供了一种用于便携式计算机设备的编程应用程序的WYSIWYG视觉编程环境。 开发人员根据开发者打算应用程序执行的底层便携式计算机设备选择一个表单外观。 窗体外观以开发人员的形式显示在实际设备之后。 开发人员可以将GUI元素拖放到表单上，而不管开发者的计算设备上使用的分辨率如何，它们的大小和分辨率与实际设备的用户大致相同。 开发人员可以将代码与GUI元素以及出现在表单外观上的任何软键相关联。 开发人员可以通过模拟便携式设备的硬件来测试应用程序，并使用窗体外观来操作设备。 通过形式皮肤，开发人员能够几乎准确地了解应用程序在底层便携式设​​备上的外观和操作，而无需离开开发环境。

公开(公告)号：US07558875B2

公开(公告)日：2009-07-07

申请号：US10662574

申请日：2003-09-15

申请人： Xin Yan Zhang ,  Qian Zhang ,  Yongqiang Xiong ,  Wenwu Zhu

发明人： Xin Yan Zhang ,  Qian Zhang ,  Yongqiang Xiong ,  Wenwu Zhu

IPC分类号： G06F15/173

CPC分类号： H04L67/104 ,  H04L41/0893 ,  H04L41/12 ,  H04L43/00 ,  H04L43/50 ,  H04L45/04 ,  H04L45/121 ,  H04L45/122 ,  H04L45/46 ,  H04L67/1046 ,  H04L67/1059 ,  H04L67/1072 ,  H04L69/329

摘要： Overlay network peers may be grouped so that each peer in a peer group has a similar transport network proximity measure with respect to the peers in other peer groups. A first set of transport network distances may include distances between a peer group and peer group neighbors of the peer group. A second set of distances may include distances between a peer and the peer group neighbors of the peer group. The peer may decide to join the peer group if the first set of distances is near to the second set. A first peer group may query a second peer group for the second peer group's neighboring peer groups. The distance between the first peer group and each of the second peer group's neighbors may be measured. Overlay network connections may be established between the first peer group and the closest of the second peer group's neighbors.

摘要翻译： 覆盖网络对等体可以被分组，使得对等体组中的每个对等体相对于其他对等体组中的对等体具有相似的传输网络邻近度量。 第一组传输网络距离可以包括对等体组和对等体组的对等体组邻居之间的距离。 第二组距离可以包括对等体组的对等体组邻居之间的距离。 如果第一组距离接近第二组，则对等体可以决定加入对等体组。 第一对等体组可以查询第二对等体组的第二对等体组的相邻对等体组。 可以测量第一对等组与每个第二对等组的邻居之间的距离。 覆盖网络连接可以在第一对等体组和第二对等体组的邻居中最接近之间建立。

公开(公告)号：US07396524B2

公开(公告)日：2008-07-08

申请号：US11194983

申请日：2005-08-02

申请人： Gan-Xin Yan

发明人： Gan-Xin Yan

IPC分类号： A61K49/00

CPC分类号： G01N33/5088 ,  G01N33/6872 ,  G01N2500/04 ,  G01N2800/326

摘要： Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.

摘要翻译： 公开了筛选化合物诱导或抑制心律不齐的潜力的方法。 所述方法包括确定表达L型钙通道的组织中的ITA，L +回收的时间常数（τ）与其治疗的L型钙通道的任何亚基或其组合的比率 使用测试化合物治疗的心脏组织的心室复极化时间的测试化合物。 所述方法还包括确定特定剂量的测试化合物的心律失常风险评分。

公开(公告)号：US20070169100A1

公开(公告)日：2007-07-19

申请号：US11266417

申请日：2005-11-03

申请人： Brian Chamberlain ,  Jason Smith ,  Xin Yan

发明人： Brian Chamberlain ,  Jason Smith ,  Xin Yan

IPC分类号： G06F9/44

CPC分类号： G06F8/71

摘要： A software development tool, in the form of an integrated development environment (IDE), comprises a managed platform registry for managing the combination of compatible target platforms and versions of a software development framework. Each compatible combination of a platform and a version of the software development framework is assigned a unique managed platform ID. The managed platform IDs and information associated therewith are managed by the managed platform registry. The software development tool provides upgrade capability allowing a developer to use a newer version of the software development framework while maintaining the current target platform. The software development tool also provides the ability to switch target platforms while maintaining the current version of the software development framework.

摘要翻译： 以集成开发环境（IDE）形式的软件开发工具包括一个管理平台注册表，用于管理兼容目标平台和软件开发框架版本的组合。 平台和软件开发框架版本的每个兼容组合都被分配一个独特的托管平台ID。 托管平台ID和与之相关联的信息由托管平台注册管理。 软件开发工具提供升级功能，允许开发人员使用较新版本的软件开发框架，同时维护当前的目标平台。 软件开发工具还提供了转换目标平台同时维护当前版本的软件开发框架的能力。

公开(公告)号：US20070031817A1

公开(公告)日：2007-02-08

申请号：US11194983

申请日：2005-08-02

申请人： Gan-Xin Yan

发明人： Gan-Xin Yan

IPC分类号： C12Q1/00

CPC分类号： G01N33/5088 ,  G01N33/6872 ,  G01N2500/04 ,  G01N2800/326

摘要： Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.

摘要翻译： 公开了筛选化合物诱导或抑制心律不齐的潜力的方法。 所述方法包括确定表达L型钙通道的组织中的ITA，L +回收的时间常数（τ）与其治疗的L型钙通道的任何亚基或其组合的比率 使用测试化合物治疗的心脏组织的心室复极化时间的测试化合物。 所述方法还包括确定特定剂量的测试化合物的心律失常风险评分。

公开(公告)号：US20050160113A1

公开(公告)日：2005-07-21

申请号：US10488118

申请日：2001-08-31

申请人： Michael Sipusic ,  Xin Yan ,  Vivek Singh ,  Tommy Nordqvist

发明人： Michael Sipusic ,  Xin Yan ,  Vivek Singh ,  Tommy Nordqvist

IPC分类号： G06F3/0485 ,  G06F17/30 ,  H04N7/24 ,  G06F17/00

CPC分类号： H04N21/435 ,  G06F3/0485 ,  G06F16/48 ,  G06F16/745 ,  G06F16/78 ,  H04N21/235

摘要： As system for navigating primary media and meta-data on a computer system is described. The system involves accessing primary media from a primary media source, and accessing meta-data from a meta-data source. The system also involves generating a graphical user interface (GUI) for providing interaction between a user and the system in relation to the primary media. The GUI includes means for facilitating control of the primary media currently being played, and means for displaying a multidimensional graphical representation for depicting a timeline for indicating the current location of the primary media being played relative to a reference location in the primary media, and providing information relating to the meta-data associated with the primary media at the current location.

摘要翻译： 描述了用于在计算机系统上导航主媒体和元数据的系统。 该系统涉及从主要媒体源访问主媒体，以及从元数据源访问元数据。 该系统还涉及生成图形用户界面（GUI），用于提供用户与系统之间相对于主要媒体的交互。 GUI包括便于控制当前正在播放的主要媒体的装置，以及用于显示多维图形表示的装置，用于描绘用于指示正​​在播放的主要媒体当前位置相对于主要媒体中的参考位置的时间线，以及提供 与当前位置的与主要媒体相关联的元数据的信息。

公开(公告)号：US09143356B2

公开(公告)日：2015-09-22

申请号：US12826040

申请日：2010-06-29

申请人： Xin Yan Wei ,  Lei Yu ,  Wei Li ,  Xiang Chen

发明人： Xin Yan Wei ,  Lei Yu ,  Wei Li ,  Xiang Chen

IPC分类号： G06F15/16 ,  H04L12/58

CPC分类号： H04L12/58 ,  H04L51/00

摘要： An Email processing method and system comprising in response to obtaining an Email, parsing contents of the Email to obtain an Email subject identifier of the Email, at least one new interaction record, and interaction information corresponding to the at least one new interaction record; determining whether there is a merged Email, which has a merge Email subject identifier matching a subject identifier of the Email, and conforms to a predefined interaction content structure comprising at least one interaction record divided by interaction relationship of contents; and in response to that the determination result is yes, merging the at least one new interaction record of the Email into the merged Email to generate a new merged Email based on the interaction information corresponding to the at least one new interaction record.

摘要翻译： 一种电子邮件处理方法和系统，包括响应于获得电子邮件，解析电子邮件的内容以获得电子邮件的电子邮件主题标识符，至少一个新的交互记录以及对应于该至少一个新交互记录的交互信息; 确定是否存在合并的电子邮件，其具有与电子邮件的主题标识符相匹配的合并电子邮件主题标识符，并且符合包含至少一个交互记录的预定交互内容结构，除以内容的交互关系; 并且响应于此，所述确定结果为是，将所述Email的所述至少一个新的交互记录合并到所述合并的电子邮件中，以基于与所述至少一个新的交互记录相对应的交互信息生成新的合并的电子邮件。