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    Lithium stimulation of cord blood stem cell proliferation and growth factor production
    2.
    发明授权
    Lithium stimulation of cord blood stem cell proliferation and growth factor production 有权
    锂刺激脐血干细胞增殖和生长因子的产生

    公开(公告)号：US08852938B2

    公开(公告)日：2014-10-07

    申请号：US12513331

    申请日：2007-10-31

    Applicant: DongMing Sun ,  Wise Young

    Inventor： DongMing Sun ,  Wise Young

    IPC: C12N5/02 ,  C12N5/0789 ,  A61K35/50

    CPC classification number: A61K35/51 ,  A61K33/00 ,  A61K35/50 ,  A61K2035/124 ,  C12N5/0605 ,  C12N5/0647 ,  C12N2500/12

    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.

    Abstract translation: 本发明提供了使用包含锂盐的体外细胞培养系统扩增人脐带血干细胞的方法和刺激脐带血干细胞生长因子的方法。 本发明还提供了通过在移植前用锂盐处理细胞来增强移植的脐带血干细胞的存活和生长的体内方法。 还提供了通过在移植后施用锂盐来减少移植的脐带血干细胞排斥的体内方法。

    LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION
    3.
    发明申请
    LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION 有权
    牙髓干细胞增殖和生长因子生成的锂刺激

    公开(公告)号：US20100189696A1

    公开(公告)日：2010-07-29

    申请号：US12513331

    申请日：2007-10-31

    Applicant: DongMing Sun ,  Wise Young

    Inventor： DongMing Sun ,  Wise Young

    IPC: A61K35/44 ,  A61K33/14 ,  A61K33/04 ,  A61K33/00 ,  A61P37/06 ,  A61P25/00 ,  C12N5/071

    CPC classification number: A61K35/51 ,  A61K33/00 ,  A61K35/50 ,  A61K2035/124 ,  C12N5/0605 ,  C12N5/0647 ,  C12N2500/12

    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.

    Abstract translation: 本发明提供了使用包含锂盐的体外细胞培养系统扩增人脐带血干细胞的方法和刺激脐带血干细胞生长因子的方法。 本发明还提供了通过在移植前用锂盐处理细胞来增强移植的脐带血干细胞的存活和生长的体内方法。 还提供了通过在移植后施用锂盐来减少移植的脐带血干细胞排斥的体内方法。

    Methods and apparatus for quantifying tissue damage, determining tissue type, monitoring neural activity, and determining hematocrit
    4.
    发明授权
    Methods and apparatus for quantifying tissue damage, determining tissue type, monitoring neural activity, and determining hematocrit 失效
    用于定量组织损伤的方法和装置，确定组织类型，监测神经活动和确定HEMATOCRIT

    公开(公告)号：US5200345A

    公开(公告)日：1993-04-06

    申请号：US561986

    申请日：1990-08-02

    Applicant: Wise Young

    Inventor： Wise Young

    IPC: G01N33/48 ,  G01N33/84

    CPC classification number: G01N33/48 ,  G01N33/84 ,  Y10T436/24

    Abstract: Tissue damage may be quantified, tissue type identified, neural activity monitored or blood hematocrit determined by measuring the difference between the total tissue sodium and potassium concentrations in the area in question. Comparison of these measurements with standard values permit evaluation of the amount of tissue damage in cells of the same type or the tissue type in non-necrotic cells. Evaluation over time of normal brain cells permit monitoring of neural activity. By directly and simultaneously measuring sodium and potassium ion concentrations, for example, a nuclear magnetic resonance spectrometer can image areas of different tissue type in differing colors. In this manner tumors and lesions can be clearly delineated. Measurement of total potassium concentration of a blood sample and the potassium concentration of the cell-free plasma will permit determination of cellular volume fraction (hematocrit).

    Abstract translation: 可以量化组织损伤，通过测量所述区域中的总组织钠和钾浓度之间的差异来确定组织类型确定，监测神经活动或血液血细胞比容。 这些测量与标准值的比较允许评估在非坏死细胞中相同类型或组织类型的细胞中组织损伤的量。 正常脑细胞随时间的评估允许监测神经活动。 通过直接并同时测量钠离子和钾离子浓度，例如，核磁共振光谱仪可以以不同颜色对不同组织类型的区域进行成像。 以这种方式可以清楚地描绘肿瘤和病变。 测量血液样品的总钾浓度和无细胞血浆的钾浓度将允许测定细胞体积分数（血细胞比容）。

    Randomized double pulse stimulus and paired event analysis
    5.
    发明授权
    Randomized double pulse stimulus and paired event analysis 失效
    随机双脉冲刺激和配对事件分析

    公开(公告)号：US5143081A

    公开(公告)日：1992-09-01

    申请号：US558345

    申请日：1990-07-27

    Applicant: Wise Young ,  Kaoru Sakatani

    Inventor： Wise Young ,  Kaoru Sakatani

    IPC: A61B5/0484 ,  A61B5/103

    CPC classification number: A61B5/4824 ,  A61B5/0484 ,  A61B5/4023 ,  A61B5/4519

    Abstract: The behavioral tendencies of a system in which responses evoked by stimuli are measurable are determined by means of a method and apparatus for applying a train of paired stimuli to the system and measuring and analyzing the response. The first of each pair of stimuli (conditioning stimulus) is applied at randomly varying intensities and at a constant interval. The second of each pair of stimuli (test stimulus) is applied at a constant intensity and a randomly varying interval from its associated test stimulus. By appropriate analysis of the amplitude and latency of the evoked responses, important information about fatigue, refractory period, supernormal period, threshold and dynamical fluctuation can be determined.

    Abstract translation: 通过用于将一对配对刺激应用于系统并测量和分析响应的方法和装置来确定由刺激引起的反应可测量的系统的行为倾向。 每对刺激（调理刺激）中的第一个以随机变化的强度和恒定的间隔施加。 每对刺激（测试刺激）中的第二个以相关的测试刺激以恒定的强度和随机变化的间隔施加。 通过适当分析诱发反应的幅度和潜伏期，可以确定疲劳，不应期，超常周期，阈值和动态波动等重要信息。

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