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    Lithium stimulation of cord blood stem cell proliferation and growth factor production
    2.
    发明授权
    Lithium stimulation of cord blood stem cell proliferation and growth factor production 有权
    锂刺激脐血干细胞增殖和生长因子的产生

    公开(公告)号：US08852938B2

    公开(公告)日：2014-10-07

    申请号：US12513331

    申请日：2007-10-31

    Applicant: DongMing Sun ,  Wise Young

    Inventor： DongMing Sun ,  Wise Young

    IPC: C12N5/02 ,  C12N5/0789 ,  A61K35/50

    CPC classification number: A61K35/51 ,  A61K33/00 ,  A61K35/50 ,  A61K2035/124 ,  C12N5/0605 ,  C12N5/0647 ,  C12N2500/12

    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.

    Abstract translation: 本发明提供了使用包含锂盐的体外细胞培养系统扩增人脐带血干细胞的方法和刺激脐带血干细胞生长因子的方法。 本发明还提供了通过在移植前用锂盐处理细胞来增强移植的脐带血干细胞的存活和生长的体内方法。 还提供了通过在移植后施用锂盐来减少移植的脐带血干细胞排斥的体内方法。

    Actuator
    3.
    发明授权
    Actuator 有权
    执行器

    公开(公告)号：US07915787B2

    公开(公告)日：2011-03-29

    申请号：US12169575

    申请日：2008-07-08

    Applicant: Mahito Negishi ,  Takao Yokomatsu ,  Ken Meisho ,  Seiichi Hata ,  Akira Shimokohbe ,  Dongming Sun ,  Sheng Wang

    Inventor： Mahito Negishi ,  Takao Yokomatsu ,  Ken Meisho ,  Seiichi Hata ,  Akira Shimokohbe ,  Dongming Sun ,  Sheng Wang

    IPC: H01L41/08

    CPC classification number: H02N2/009 ,  H02N2/021 ,  H02N2/08

    Abstract: A cylindrical piezoelectric element is arranged to share an axis with a cylindrical vibrator having different diameters at central and end portions to fix the vibrator forming a gap at the central portion. Vibration voltages are applied across first electrodes on the piezoelectric element and the vibrator, namely, a second electrode, to vibrate the vibrator and bring a wave front of a traveling wave into contact with a tubular member, i.e., a supporting member fitted to the vibrator. Friction at a contact portion of the vibrator moves a mover including the vibrator and the piezoelectric element in an axial direction of the tubular member. By amplifying the vibration amplitude using the vibrator provided separately from the piezoelectric element, a small actuator capable of performing high-speed driving is realized.

    Abstract translation: 圆柱形压电元件被布置成与中心部分和端部具有不同直径的圆柱形振动器共轴以固定在中心部分形成间隙的振动器。 在压电元件和振动器（即第二电极）上的第一电极上施加振动电压，以使振动器振动并使行波的波前与管状构件（即，安装到振动器的支撑构件）接触 。 在振动器的接触部分的摩擦使包括振动器和压电元件在内的动子在管状构件的轴向上移动。 通过使用与压电元件分开设置的振动器放大振动振幅，实现了能够进行高速驱动的小型致动器。

    LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION
    4.
    发明申请
    LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION 有权
    牙髓干细胞增殖和生长因子生成的锂刺激

    公开(公告)号：US20100189696A1

    公开(公告)日：2010-07-29

    申请号：US12513331

    申请日：2007-10-31

    Applicant: DongMing Sun ,  Wise Young

    Inventor： DongMing Sun ,  Wise Young

    IPC: A61K35/44 ,  A61K33/14 ,  A61K33/04 ,  A61K33/00 ,  A61P37/06 ,  A61P25/00 ,  C12N5/071

    CPC classification number: A61K35/51 ,  A61K33/00 ,  A61K35/50 ,  A61K2035/124 ,  C12N5/0605 ,  C12N5/0647 ,  C12N2500/12

    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.

    Abstract translation: 本发明提供了使用包含锂盐的体外细胞培养系统扩增人脐带血干细胞的方法和刺激脐带血干细胞生长因子的方法。 本发明还提供了通过在移植前用锂盐处理细胞来增强移植的脐带血干细胞的存活和生长的体内方法。 还提供了通过在移植后施用锂盐来减少移植的脐带血干细胞排斥的体内方法。

    ACTUATOR
    5.
    发明申请
    ACTUATOR 有权
    执行机构

    公开(公告)号：US20090021113A1

    公开(公告)日：2009-01-22

    申请号：US12169575

    申请日：2008-07-08

    Applicant: Mahito Negishi ,  Takao Yokomatsu ,  Ken Meisho ,  Seiichi Hata ,  Akira Shimokohbe ,  Dongming Sun ,  Sheng Wang

    Inventor： Mahito Negishi ,  Takao Yokomatsu ,  Ken Meisho ,  Seiichi Hata ,  Akira Shimokohbe ,  Dongming Sun ,  Sheng Wang

    IPC: H02N2/02

    CPC classification number: H02N2/009 ,  H02N2/021 ,  H02N2/08

    Abstract: A cylindrical piezoelectric element is arranged to share an axis with a cylindrical vibrator having different diameters at central and end portions to fix the vibrator forming a gap at the central portion. Vibration voltages are applied across first electrodes on the piezoelectric element and the vibrator, namely, a second electrode, to vibrate the vibrator and bring a wave front of a traveling wave into contact with a tubular member, i.e., a supporting member fitted to the vibrator. Friction at a contact portion of the vibrator moves a mover including the vibrator and the piezoelectric element in an axial direction of the tubular member. By amplifying the vibration amplitude using the vibrator provided separately from the piezoelectric element, a small actuator capable of performing high-speed driving is realized.

    Abstract translation: 圆柱形压电元件被布置成与中心部分和端部具有不同直径的圆柱形振动器共轴以固定在中心部分形成间隙的振动器。 在压电元件和振动器（即第二电极）上的第一电极上施加振动电压，以使振动器振动并使行波的波前与管状构件（即，安装到振动器的支撑构件）接触 。 在振动器的接触部分的摩擦使包括振动器和压电元件在内的动子在管状构件的轴向上移动。 通过使用与压电元件分开设置的振动器放大振动振幅，实现了能够进行高速驱动的小型致动器。

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