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公开(公告)号：US5631299A
公开(公告)日：1997-05-20
申请号：US461594
申请日：1995-06-05
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US5631292A
公开(公告)日：1997-05-20
申请号：US460581
申请日：1995-06-02
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
IPC分类号： A23L27/20 , A23L27/21 , A23L27/30 , A23L27/40 , A61K31/195
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US4362699A
公开(公告)日：1982-12-07
申请号：US242232
申请日：1981-03-10
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00418 , B01J2219/00495 , B01J2219/00497 , B01J2219/0059 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B60/14 , Y02P20/582
摘要： An apparatus for synthesizing a polypeptide chain on an insoluble solid support in a continuous flow reactor by performing a series of stepwise coupling reactions under high pressure is disclosed. A deprotecting agent reservoir, a solvent reservoir, a neutralizing solution reservoir, and a plurality of amino acid reservoirs are provided. Each reservoir can be selectively coupled to the reactor and a source of high pressure inert gas or an appropriate pump can be used to force the fluids as needed to the reactor. The reactor also includes a recycle loop whereby the amino acid from a particular reservoir can be recycled through the reactor under high pressure.
摘要翻译： 公开了一种用于在连续流动反应器中通过在高压下进行一系列逐步偶联反应来在不溶性固体载体上合成多肽链的装置。 提供了脱保护剂储存器，溶剂储存器，中和溶液储存器和多个氨基酸储存器。 每个储存器可以选择性地耦合到反应器，并且可以使用高压惰性气体源或适当的泵来迫使反应器所需的流体。 反应器还包括循环回路，其中来自特定储存器的氨基酸可以在高压下再循环通过反应器。
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公开(公告)号：US4351762A
公开(公告)日：1982-09-28
申请号：US242310
申请日：1981-03-10
IPC分类号： C07K1/08 , C07K5/06 , C07K5/103 , C07C103/52
CPC分类号： C07K5/0606 , C07K1/08 , C07K5/101
摘要： In the synthesis of a polypeptide chain wherein an N.sup..alpha. -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.
摘要翻译： 在其中Nα-氨基甲酸酯保护的氨基酸混合酸酐与氨基未受保护的第二氨基酸偶联的多肽链的合成中，改进包括在室温或更高温度下进行所述偶联。 该方法提供快速，基本上定量的反应，而不需要降低温度。 该方法在肽的固相合成中特别有用，其中获得缩短的偶联循环和改进的基本上纯的产物的产率。
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公开(公告)号：US6015792A
公开(公告)日：2000-01-18
申请号：US42148
申请日：1998-03-13
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
IPC分类号： A23L27/20 , A23L27/21 , A61K38/05 , A01N37/14 , A01N37/28 , C07C205/02 , C07C229/08
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
摘要翻译： 可食用的化合物，其基本上无味，并且已经被发现是有用的还原剂或消除者对食物不期望的口味。
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公开(公告)号：US5646122A
公开(公告)日：1997-07-08
申请号：US456796
申请日：1995-06-01
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US5641812A
公开(公告)日：1997-06-24
申请号：US464086
申请日：1995-06-05
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US5641811A
公开(公告)日：1997-06-24
申请号：US459702
申请日：1995-06-02
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US5641799A
公开(公告)日：1997-06-24
申请号：US464283
申请日：1995-06-05
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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公开(公告)号：US5641795A
公开(公告)日：1997-06-24
申请号：US464090
申请日：1995-06-05
申请人： Robert J. Kurtz , William D. Fuller
发明人： Robert J. Kurtz , William D. Fuller
IPC分类号： A23L27/20 , A23L27/21 , A23L27/30 , A23L27/40 , A61K31/425
CPC分类号： A23L27/40 , A23L27/20 , A23L27/2028 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/21 , A23L27/32 , A23L27/33 , A23L27/37 , A23L27/39
摘要： Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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