公开(公告)号：US06358512B1

公开(公告)日：2002-03-19

申请号：US09592991

申请日：2000-06-13

申请人： Raphael Darteil ,  Wayne Corapi ,  Jean-Christophe Francis Audonnet ,  Gilles Emile Chappuis

发明人： Raphael Darteil ,  Wayne Corapi ,  Jean-Christophe Francis Audonnet ,  Gilles Emile Chappuis

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/525 ,  C12N2710/24143 ,  C12N2740/15022 ,  C12N2770/20022 ,  G06F19/00 ,  G16H40/63 ,  Y02A90/26

摘要： The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions A1 and A2 which are involved in enhancement, as well as the use of these sequences for the expression of modified proteins, and for the construction of recombinant viruses or expression plasmids, and the use of the recombinant viruses as vaccines against feline infectious peritonitis, the use of the expression plasmids as immunizing composition by direct injection of the said plasmids into cats, and the use of the modified proteins as vaccine.

摘要翻译： 本发明包括在涉及增强的至少一个抗原区A1和A2中修饰的包含FIPV S基因或该基因的片段的核苷酸序列，以及这些序列用于表达的用途 的修饰蛋白质，以及用于构建重组病毒或表达质粒，以及使用重组病毒作为针对猫感染性腹膜炎的疫苗，通过将所述质粒直接注射入猫中将表达质粒用作免疫组合物，以及 使用修饰的蛋白作为疫苗。

公开(公告)号：US6096535A

公开(公告)日：2000-08-01

申请号：US196187

申请日：1998-11-20

申请人： Raphael Darteil ,  Wayne Corapi ,  Jean-Christophe Fran.cedilla.is Audonnet ,  Gilles Emile Chappuis

发明人： Raphael Darteil ,  Wayne Corapi ,  Jean-Christophe Fran.cedilla.is Audonnet ,  Gilles Emile Chappuis

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/215 ,  A61P31/12 ,  C07K14/155 ,  C07K14/165 ,  C12N15/50

CPC分类号： C07K14/005 ,  G06F19/3406 ,  A61K2039/51 ,  A61K2039/525 ,  A61K39/00 ,  C12N2710/24143 ,  C12N2740/15022 ,  C12N2770/20022

摘要： The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions A1 and A2 which are involved in enhancement, as well as the use of these sequences for the expression of modified proteins, and for the construction of recombinant viruses or expression plasmids, and the use of the recombinant viruses as vaccines against feline infectious peritonitis, the use of the expression plasmids as immunizing composition by direct injection of the said plasmids into cats, and the use of the modified proteins as vaccine.

公开(公告)号：US6080850A

公开(公告)日：2000-06-27

申请号：US519979

申请日：1995-08-28

申请人： Raphael Darteil ,  Wayne Corapi ,  Franqis Jean-Christophe Audonnet ,  Emile Gilles Chappuis

发明人： Raphael Darteil ,  Wayne Corapi ,  Franqis Jean-Christophe Audonnet ,  Emile Gilles Chappuis

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/215 ,  A61P31/12 ,  C07K14/155 ,  C07K14/165 ,  C12N15/50 ,  C07H21/04 ,  C07K1/00

CPC分类号： C07K14/005 ,  G06F19/3406 ,  A61K2039/51 ,  A61K2039/525 ,  A61K39/00 ,  C12N2710/24143 ,  C12N2740/15022 ,  C12N2770/20022

摘要： The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions A1 and A2 which are involved in enhancement, as well as the use of these sequences for the expression of modified proteins, and for the construction of recombinant viruses or expression plasmids, and the use of the recombinant viruses as vaccines against feline infectious peritonitis, the use of the expression plasmids as immunizing composition by direct injection of the said plasmids into cats, and the use of the modified proteins as vaccine.