-
公开(公告)号：US11642391B2
公开(公告)日：2023-05-09
申请号：US15502170
申请日：2015-08-04
Applicant: Vascular BioSciences , Sanford Burnham Prebys Medical Discovery Institute , David Mann , Erkki Ruoslahti , Masanobu Komatsu
Inventor： David Mann , Erkki Ruoslahti , Masanobu Komatsu
IPC: A61K38/12 , G16B35/00 , G16C20/60 , A61K31/337 , A61K31/506 , A61K38/55 , A61K45/06 , A61K31/222 , A61K31/573 , A61K47/68 , A61K47/64 , G01N33/15 , G16B35/20 , G16B35/10 , A61P31/00 , A61P1/16 , A61P9/12 , A61P13/12 , A61P11/00 , A61P35/00 , A61K31/18 , A61K31/436 , A61K31/438 , A61K38/08 , G01N33/50
CPC classification number: A61K38/12 , A61K31/18 , A61K31/222 , A61K31/337 , A61K31/436 , A61K31/438 , A61K31/506 , A61K31/573 , A61K38/08 , A61K38/55 , A61K45/06 , A61K47/64 , A61K47/643 , A61K47/6811 , A61K47/6851 , A61P1/16 , A61P9/12 , A61P11/00 , A61P13/12 , A61P31/00 , A61P35/00 , G01N33/15 , G01N33/5008 , G16B35/00 , G16B35/10 , G16B35/20 , G16C20/60 , A61K31/506 , A61K2300/00 , A61K31/222 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/573 , A61K2300/00
Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.
-
2.发明授权公开(公告)号：US10039838B2
公开(公告)日：2018-08-07
申请号：US14936969
申请日：2015-11-10
Inventor： Masanobu Komatsu , David Mann , Erkki Ruoslahti
IPC: C07K7/06 , A61K38/08 , A61K47/48 , A61K45/06 , A61K31/506 , A61K31/551 , C12Q1/6883 , A61K47/64 , A61K38/00
Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
-
公开(公告)号：US09655973B2
公开(公告)日：2017-05-23
申请号：US14383818
申请日：2013-03-11
Applicant: Vascular Biosciences
Inventor： David M. Mann
IPC: A61K38/08 , A61K47/42 , A61K45/06 , C07K7/06 , A61K47/48 , A61K9/00 , A61K31/506 , A61K31/519 , A61K38/00
CPC classification number: A61K47/42 , A61K9/0053 , A61K31/506 , A61K31/519 , A61K38/00 , A61K45/06 , A61K47/62 , C07K7/06
Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.
-
公开(公告)号：US09603890B2
公开(公告)日：2017-03-28
申请号：US14649455
申请日：2013-12-03
Applicant: Vascular Biosciences
Inventor： David Mann
CPC classification number: A61K38/08 , A61K45/06 , C12Q1/34 , G01N33/6893 , G01N2333/926 , G01N2800/12 , G01N2800/321
Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.
-
公开(公告)号：US20230137434A1
公开(公告)日：2023-05-04
申请号：US17912312
申请日：2021-03-19
Applicant: Vascular Biosciences
Inventor： David Mann
IPC: A61K47/64 , A61K31/573 , A61P9/00 , A61P37/06 , A61P31/14 , A61K47/55 , A61K9/127 , A61P29/00 , A61K31/706 , A61K39/395 , A61K49/18 , A61K49/10 , A61K49/14 , A61P3/10 , A61K31/197 , A61K38/36 , A61K38/21 , A61K51/08 , A61K9/00 , A61K38/08
Abstract: A conjugate for treating an individual suffering from a disease, wherein the conjugate is comprised of: a targeting peptide comprising a sequence substantially identical to CAR, or a variant thereof; and at least one therapeutic molecule and methods for making and administering same. Also disclosed is a combination product for use in the treatment of a disease, wherein the combination product comprises: (a) a targeting peptide comprising a sequence substantially identical to CAR, or a variant thereof; (b) a liposome, wherein the targeting peptide is encapsulated within the liposome; and (c) an effective amount of an anti-inflammatory agent and methods for making and administering same.
-
Patent Agency Ranking
公开(公告)号：US20210010082A1
公开(公告)日：2021-01-14
申请号：US16908540
申请日：2020-06-22
Applicant: Vascular Biosciences
Inventor： David M. Mann
IPC: C12Q1/6883 , G01N1/00 , C12N15/113 , A61K31/122 , A61K31/192 , A61K31/352 , A61K31/4545 , A61K31/47 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/20 , A61K38/28 , A61K38/48
Abstract: Multiple treatment regimens for vascular-related diseases and disorders. Methods of treating vascular-related disorders based on gene expression studies from samples collected from individuals having symptoms of vascular-related disorders. Additionally, methods for diagnostic techniques to focus treatment regimens. Finally, methods of treating vascular-related disorders involving targeting microRNAs.
-
7.发明申请公开(公告)号：US20190022170A1
公开(公告)日：2019-01-24
申请号：US15502170
申请日：2015-08-04
Applicant: David MANN , Erkki RUOSLAHTI , Masanobu KOMATSU , Vascular BioSciences , Sanford Burnham Prebys Medical Discovery Institute
Inventor： David Mann , Erkki Ruoslahti , Masanobu Komatsu
IPC: A61K38/12 , A61K38/08 , A61K47/64 , A61K31/436 , A61K31/438 , A61K31/18 , A61K31/337 , A61K31/506 , A61P13/12 , A61P31/00 , A61P11/00 , A61P1/16 , A61P35/00 , A61P9/12 , G01N33/50 , C40B50/02
Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.
-
8.发明申请Methods for Increasing the Selective Efficacy of Gene Therapy Using CAR Peptide and Heparan-Sulfate Mediated Macropinocytosis 有权使用CAR肽和肝素 - 硫酸盐介导的巨噬细胞增多的基因疗法提高选择功效的方法公开(公告)号：US20160022759A1
公开(公告)日：2016-01-28
申请号：US14649455
申请日：2013-12-03
Applicant: David MANN , Vascular BioSciences
Inventor： David Mann
CPC classification number: A61K38/08 , A61K45/06 , C12Q1/34 , G01N33/6893 , G01N2333/926 , G01N2800/12 , G01N2800/321
Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.
Abstract translation: 公开了用于引发疾病选择性巨噬细胞增多症的组合物和方法。 组合物可以作为疾病活动的标志物，并且作为经历疾病重塑的组织中增强的巨噬细胞增多的触发因素，例如伤口愈合，癌症，PAH，炎症，糖尿病，克罗恩病，溃疡性结肠炎，强直性脊柱炎，子宫内膜疾病，牛皮癣 肠易激综合征，关节炎，纤维化疾病，间质性膀胱炎，自身免疫疾病，哮喘，急性肺损伤和成人呼吸窘迫综合征。 组合物还可以用作疾病选择性细胞穿透肽在患病组织的细胞和细胞外基质中的受体。
-
公开(公告)号：US11524077B2
公开(公告)日：2022-12-13
申请号：US16878325
申请日：2020-05-19
Applicant: Vascular BioSciences
Inventor： David Mann
IPC: A61K47/42 , A61K47/62 , A61K45/06 , C07K7/06 , A61K9/00 , A61K31/506 , A61K31/519 , A61K38/00
Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.
-
10.发明申请公开(公告)号：US20190134211A1
公开(公告)日：2019-05-09
申请号：US16057696
申请日：2018-08-07
Inventor： Masanobu Komatsu , David Mann , Erkki Ruoslahti
IPC: A61K47/64 , A61K31/506 , C07K7/06 , A61K45/06 , A61K38/08 , C12Q1/6883 , A61K31/551
Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.015 seconds)
